Associação entre megaesôfago e carcinoma de esôfago

Abstract

A o reverm os a literatu ra, co n stata m o s a p u b li cação de 54 casos da associação C a E -M E C h 3 5 7 8 ' 10 l:. Em term os percentuais, as freqüências regis trad as de C aE no M E C h v ariam de 1,1* a 6,6% '. N ão se tem avaliado, to d av ia, se tal associação ê ocasional ou estatisticam en te significativa. U m a o u tra possibilidade até ag o ra não an a lisa d a é a de que o C aE se relacione à infecção chagásica, e não ao " m ega" ; em o u tras palav ras, o ind iv íd u o teria m aior p ropensão ao C aE p o r ser chagásico, e não p o r ter M E. MATERIAL E MÉTODOSF o ram revistos os p ro to c o lo s de to d a s as ne cropsias efetu ad as nos serviços d e A n a to m ia P a to lógica do C en tro de C iências B iom édicas d a U n i versidade F ederal de U b erlân d ia e d a F acu ld ad e de M edicina do T riân g u lo M ineiro (U b e ra b a ), no período de jan e iro de 1956 a m aio de 1982. D a d a a rarid ad e, na infância, ta n to d o M E C h , q u a n to do C aE , apenas se co n sid eraram as n ecro p sias de in divíduos que tin h am 15 ou m ais an o s de idade. D esprezaram -se os casos em que o tó rax n ão foi ex am in ad o e em que a idade n ão foi a n o ta d a . C om tais restrições, restou um to tal de 3.474 casos, que foram divididos nos seguintes g rupos: chagásicos com M E; chagásicos sem M E ; n ão -chagásicos. C ad a um destes g ru p o s foi an alisad o q u a n to à oco rrência ou n ão de C aE , ta n to g lo b alm en te q u a n to su bdivididos p o r faixas etárias.

Association of uterine leiomyoma and Chagas' disease.

“…Nonetheless, given that the frequency of this neoplasia was similar between non-Chagas' and Chagas' disease patients without megaesophagus, the authors emphasized that the association appeared to be with the megaesophagus and not just with the Chagas infection. 4 Also, the association of chagasic megacolon and colon cancer have been reported in literature. 7 Nevertheless, others did not find such association.…”

“…[1][2][3][4][5][6] It has been associated with a greater frequency of malignant neoplasias in Chagas' disease patients than in non-Chagas' disease patients; in a comparison of the tumor sites, a significantly greater frequency of esophagus cancer and uterine cervix in the Chagas group was observed. 3 A revision of necropsies showed that there was greater frequency of carcinomas of the esophagus among Chagas' disease patients with megaesophagus compared with non-Chagas' disease patients.…”

Leiomyosarcoma of the esophagus in a patient with chagasic megaesophagus: case report and literature review.

“…6 Cancer of the esophagus represents 6.5% of the malignant neoplasias of the digestive tube, of which 91.3% are epidermoid carcinomas and 8.7% are adenocarcinomas. 7 An increased frequency of epidermoid carcinoma in chagasic megaesophagus has been noted, varying from 1.1% to 6.6%, 4,8 whereas this neoplasia is encountered in approximately 0.5% of the population in central Brazil when not associated with chagasic megaesophagus. 4 There is evidence of an association between Chagas' disease and carcinoma of the esophagus, 9 although this is related to megaesophagus and not directly to chagasic infection.…”

“…7 An increased frequency of epidermoid carcinoma in chagasic megaesophagus has been noted, varying from 1.1% to 6.6%, 4,8 whereas this neoplasia is encountered in approximately 0.5% of the population in central Brazil when not associated with chagasic megaesophagus. 4 There is evidence of an association between Chagas' disease and carcinoma of the esophagus, 9 although this is related to megaesophagus and not directly to chagasic infection. 4 Studies indicate that there is no association between chagasic megacolon and cancer of the colon 2,6,10 or between chagasic cardiopathy and cardiac neoplasias or neoplasias of other organs.…”

“…[1][2][3][4][5] However, we are unaware of any studies showing an association between megaesophagus and leiomyosarcoma. We report herein a case of chagasic megaesophagus who developed leiomyosarcoma of the esophagus.…”