Associação de emblica, licorice e belides como alternativa à hidroquinona no tratamento clínico do melasma

Costa, Adilson; Moisés, Thaís Abdalla; Cordero, Tatiana; Alves, Caroline Romanelli Tibúrcio; Marmirori, Juliana

doi:10.1590/s0365-05962010000500003

Cited by 46 publications

(53 citation statements)

References 26 publications

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“…Results showed that the tonic could improve scalp dryness, itching, and microinflammation. Costa et al (2010) conducted a study using 56 volunteers with melasma, in which patients were divided into two treatment groups; the first group applied cream with emblica, licorice, and belides (7%) twice a day, whereas the second group applied hydroquinone cream (2%) at night, both for 60 consecutive days (Costa et al, 2010). There was no significant difference in the improvement of melasma between the two groups.…”

Section: Skin Disordersmentioning

confidence: 99%

Pharmacological Effects ofGlycyrrhizaspp. and Its Bioactive Constituents: Update and Review

2015

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The roots and rhizomes of various species of the perennial herb licorice (Glycyrrhiza) are used in traditional medicine for the treatment of several diseases. In experimental and clinical studies, licorice has been shown to have several pharmacological properties including antiinflammatory, antiviral, antimicrobial, antioxidative, antidiabetic, antiasthma, and anticancer activities as well as immunomodulatory, gastroprotective, hepatoprotective, neuroprotective, and cardioprotective effects. In recent years, several of the biochemical, molecular, and cellular mechanisms of licorice and its active components have also been demonstrated in experimental studies. In this review, we summarized the new phytochemical, pharmacological, and toxicological data from recent experimental and clinical studies of licorice and its bioactive constituents after our previous published review.

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Section: Skin Disordersmentioning

confidence: 99%

Pharmacological Effects ofGlycyrrhizaspp. and Its Bioactive Constituents: Update and Review

2015

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“…Skin pigmentation disorders consist of an overproduction or uneven distribution of melanin, which results in skin spots that mainly affect mainly the face [2]. Such conditions may arise due to numerous factors, including skin aging, sun exposure [3,4], genetic factors [5], ethnicity [6,7], pregnancy [8], disease [9,10], use of certain medicines [11] and others.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effects of Resveratrol Analogs on Mushroom Tyrosinase Activity

et al. 2012

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Skin pigmentation disorders typically involve an overproduction or uneven distribution of melanin, which results in skin spots. Resveratrol can inhibit tyrosinase, the active enzyme in the synthesis of melanin, but it does not inhibit the synthesis of melanin to an extent that enables its use alone as a skin whitening agent in pharmaceutical formulations, so its use as a coadjuvant in treatment of hyperpigmentation is suggested. Six resveratrol analogs were tested for tyrosinase inhibitory activity in vitro. Among the analogs tested, compound D was the most powerful tyrosinase inhibitor (IC50 = 28.66 µg/mL), two times more active than resveratrol (IC50 = 57.05 µg/mL), followed by the analogs A, E, B, F and C, respectively. This demonstrated that the hydroxylation at C4' on the phenolic ring was the molecular modification with most importance for the observed activity.

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“…The analysis proved that the size of melasma was significantly reduced in the three facial regions at all experimental timepoints. A similar methodology has been used in previous studies [28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of an Oral Nutritional (Dietary) Supplement Containing Pinus pinaster Bark Extract and Grape Seed Extract in Combination with a High SPF Sunscreen in the Treatment of Mild-to-Moderate Melasma: A Prospective Clinical Study

et al. 2019

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Background: Melasma is a common hyperpigmentation disorder, characterized by light-to-dark brown patches, usually distributed on sun-exposed areas of the body. The objective of this study was to evaluate the efficacy and tolerability of an oral nutritional supplement containing Pinus pinaster and Grape seed extract, vitamins and minerals, used concomitantly with a high SPF sunscreen in 30 women with mild-to-moderate facial melasma. Methods: Efficacy was assessed by measurement of the Melasma Area and Severity Index (MASI), instrumental analysis of the lesions (Mexameter®, VISIA®)) and Patient’s and Physician’s Global Assessment (PGA). Results: The MASI score decreased significantly compared with baseline at days 28, 56, and 84. Mexameter® analysis showed a significant decrease of ∆M (difference in the melanin index between melasma and adjacent area). VISIA® results also showed a reduction in the number and areas of UV pigmented spots and in the areas of melasma overtime. Both the Patient’s and Physician’s Global Assessment showed that the product led to an improvement of the lesions in terms of depigmentation and had positive cosmetic features without adverse events. Conclusion: The oral supplement subject of this study in combination with high SPF sunscreen was effective and well-tolerated for treatment of mild to moderate facial melasma.

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Associação de emblica, licorice e belides como alternativa à hidroquinona no tratamento clínico do melasma

Cited by 46 publications

References 26 publications

Pharmacological Effects ofGlycyrrhizaspp. and Its Bioactive Constituents: Update and Review

Pharmacological Effects ofGlycyrrhizaspp. and Its Bioactive Constituents: Update and Review

Inhibitory Effects of Resveratrol Analogs on Mushroom Tyrosinase Activity

Efficacy and Safety of an Oral Nutritional (Dietary) Supplement Containing Pinus pinaster Bark Extract and Grape Seed Extract in Combination with a High SPF Sunscreen in the Treatment of Mild-to-Moderate Melasma: A Prospective Clinical Study

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