Assisted reproductive technology in Europe, 2013: results generated from European registers by ESHRE†

Calhaz‐Jorge, Carlos; Geyter, Christian De; Kupka, M.; Mouzon, J. de; Erb, Karin; Mocanu, Edgar; Motrenko, T; Scaravelli, G.; Wyns, Christine; Goossens, Alain

doi:10.1093/humrep/dex264

Cited by 261 publications

(93 citation statements)

References 5 publications

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“…However, approximately 50% of embryos produced by IVF arrest before the development of the blastocyst, and the majority of transferred embryos (~70%) fail to implant (Sharkey & Macklon, ). Recent studies have shown that blastocyst stage transfer improves the successful pregnancy rate but ART‐related multiple births are frequently observed (Kissin et al, ; Sunderam et al, ; The European et al, ). Thus, elective single embryo transfer is recommended to reduce multiple gestation rates and maximise singleton pregnancies without compromising the overall success rate (A. M. Lee, Connell, Csokmay, & Styer, ).…”

Section: Introductionmentioning

confidence: 99%

The Cxadr–Adam10 complex plays pivotal roles in tight junction integrity and early trophoblast development in mice

Jeong

Ock

Yoo

et al. 2019

Molecular Reproduction Devel

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Understanding preimplantation embryo development has important implications for assisted reproductive technologies (ARTs) after the introduction of in vitro fertilisation and embryo transfer because most embryonic losses occur during pre/peri‐implantation. Recent studies have shown that tight junctions (TJs) are important components for embryos to develop to the blastocyst stage. However, their biological function after cavitation has not been extensively studied. We examined TJ assembly focusing on coxsackievirus and adenovirus receptor (Cxadr) and A disintegrin and metalloproteinase 10 (Adam10) using siRNA and/or an Adam10‐specific inhibitor (GI254023X). TJ‐associated genes, including occludin and tight junction protein 1 (Tjp1), were downregulated in the Cxadr knockdown (KD) embryos but were unaltered in Adam10 KD embryos. However, Adam10 KD or chemical inhibition affected subcellular localisation of Adam10, Cxadr, and Tjp1, leading to disrupted TJ assembly. Furthermore, Cxadr KD or GI254023X‐treated blastocysts showed a relatively smaller outgrowth area and aberrant expression of transcription factor AP‐2γ, a trophoblast‐specific marker in the in vitro embryo outgrowth assay. In summary, we demonstrated that the Cxadr–Adam10 complex might moderate TJ integrity/stability and play pivotal roles during early embryonic development. Collectively, understanding the establishment of the TJ complex and its integrity will provide insight into translational research for predicting and selecting developmental competency for ART.

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Section: Introductionmentioning

confidence: 99%

The Cxadr–Adam10 complex plays pivotal roles in tight junction integrity and early trophoblast development in mice

Jeong

Ock

Yoo

et al. 2019

Molecular Reproduction Devel

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“…A 2.07‐fold increase in the number of IVF treatments has been noted from 2008 when the cycle‐based registry was introduced . Nevertheless, clinical pregnancy rates have not increased in Japan as well as in developed countries . The main reason for this is that age is a major prognostic factor influencing the success rate of IVF, which cannot be altered.…”

Section: Introductionmentioning

confidence: 99%

Lack of a meaningful association between dietary patterns and in vitro fertilization outcome among Japanese women

Sugawa¹,

Okubo

Sasaki

et al. 2018

Reprod Medicine & Biology

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PurposeThe purpose of this study was to examine whether preconception maternal dietary pattern is associated with in vitro fertilization (IVF) outcome among Japanese women.MethodsThis prospective study included 140 Japanese women who underwent conventional‐IVF/intracytoplasmic sperm injection. The patients’ diets during the previous month before egg retrieval were assessed with validated brief‐type self‐administered diet history questionnaire. Dietary patterns from 33 predefined food groups [energy‐adjusted food (g/1000 kcal)] were extracted by factor analysis. The primary outcome measure was clinical pregnancy rate after IVF.ResultsThirty‐six women had confirmed clinical pregnancy. Three dietary patterns were identified: “Vegetable and seafood,” “Western,” and “Rice and miso soup.” The “Vegetables and seafood” dietary pattern (high intakes of green and other vegetables, mushrooms, seasoning, fish, soy products, chicken, and potatoes) was not associated with clinical pregnancy ([odds ratio per one‐quartile increase in dietary pattern: 0.94 (95% confidence interval: 0.67‐1.32), P = 0.73]. This relationship was unaltered after controlling for potential confounders. Furthermore, no association was seen between the other two dietary patterns and clinical pregnancy.ConclusionsThe three maternal preconception dietary patterns identified revealed no meaningful association with IVF outcome in Japanese women. Further studies in various populations with different dietary patterns are needed to confirm these findings.

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“…Double-embryo transfers (DETs) still hold a dominant position despite the increasing number of single-embryo transfer (SET) procedures. In Europe, the rates of SET and DET were 22.4% and 53.2%, respectively, in 2008 and 31.4% and 56.3%, respectively, in 2012 [2, 3]. A meta-analysis found that the live birth rate was lower for SET than for DET, while the live birth rate of a repeated SET (two cycles of SET) was not different from that of a DET [4].…”

Section: Introductionmentioning

confidence: 99%

Does a poor-quality embryo have an adverse impact on a good-quality embryo when transferred together?

Zhang

et al. 2018

J Ovarian Res

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BackgroundIn some in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles, we may consider transferring one poor-quality embryo with one good-quality embryo. Previous studies have indicated that the poor-quality embryo transferred with a good-quality embryo does not negatively affect the clinical pregnancy rate or live birth rate. The purpose of this study was to evaluate pregnancy outcomes and neonatal outcomes in this context.MethodsThis was a retrospective study that included 1646 cycles from our centre. Patients were divided into two groups (group A: one good-quality embryo was transferred with one poor-quality embryo; group B: two good-quality embryos were transferred). The primary outcomes were the clinical pregnancy rate and live birth rate. Additionally, we investigated the implantation rate, ectopic pregnancy rate, abortion rate, multiple pregnancy rate, birthweight and gestational age.ResultsWe found that there were no differences in the clinical pregnancy rate and live birth rate between group A and group B. However, the implantation rate and multiple pregnancy rate were higher in group B than in group A.ConclusionsThe poor-quality embryo does not have a significant influence on the good-quality embryo when transferred together.

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Assisted reproductive technology in Europe, 2013: results generated from European registers by ESHRE†

Abstract: The study has no external funding; all costs are covered by ESHRE. There are no competing interests.

Cited by 261 publications

References 5 publications

The Cxadr–Adam10 complex plays pivotal roles in tight junction integrity and early trophoblast development in mice

The Cxadr–Adam10 complex plays pivotal roles in tight junction integrity and early trophoblast development in mice

Lack of a meaningful association between dietary patterns and in vitro fertilization outcome among Japanese women

Does a poor-quality embryo have an adverse impact on a good-quality embryo when transferred together?

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