Assisted reproductive technologies for male subfertility

Cissen, M.; Bensdorp, A.J.; Cohlen, Ben J; Repping, Sjoerd; Bruin, Jan Peter de; Wely, Madelon van

doi:10.1002/14651858.cd000360.pub5

Cited by 42 publications

(38 citation statements)

References 113 publications

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“…However, when semen is processed on the day before insemination, it is possible that more couples had intercourse the evening before insemination compared with those inseminated on the day of semen processing. Although this may have caused a difference, ovarian stimulation and timed intercourse for unexplained subfertility have not been shown to result in more ongoing pregnancies compared with expectant management or IUI (1,12). We thus do not believe that this influenced the study outcome.…”

Section: Discussionmentioning

confidence: 93%

Longer time interval between semen processing and intrauterine insemination does not affect pregnancy outcome

Jansen

Elisen

Leenstra

et al. 2017

Fertility and Sterility

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Section: Discussionmentioning

confidence: 93%

Longer time interval between semen processing and intrauterine insemination does not affect pregnancy outcome

Jansen

Elisen

Leenstra

et al. 2017

Fertility and Sterility

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“…In recent years, an increasing number of reports have demonstrated a global trend indicating a significant deterioration in male reproductive function (3–5). In parallel, obesity rates are increasing rapidly worldwide (6,7), which is not only associated with an increased risk of developing chronic diseases, but has also been demonstrated to increase the risk of developing reproductive disorders (8).…”

Section: Introductionmentioning

confidence: 99%

Protective effect of resveratrol on spermatozoa function in male infertility induced by excess weight and obesity

Cui¹,

Xuan

Wu³

et al. 2016

Molecular Medicine Reports

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Male infertility is a complex, multifactorial and polygenic disease that contributes to ~50% cases of infertility. Previous studies have demonstrated that excess weight and obesity factors serve an important role in the development of male infertility. An increasing number of studies have reported that resveratrol may regulate the response of cells to specific stimuli that induce cell injury, as well as decrease germ cell apoptosis in mice or rats. In the present study, the semen quality and serum sex hormone levels were evaluated in 324 men, which included 73 underweight, 82 normal weight, 95 overweight and 74 obese men. All patients were referred to The Reproductive Medicine Center of Shanxi Women and Infants Hospital (Taiyuan, China) between January 2013 and January 2015. The aim of the present study was to investigate the effects of resveratrol treatment on the motility, plasma zinc concentration and acrosin activity of sperm from obese males. The sperm concentration, normal sperm morphology, semen volumes, DNA fragmentation rates and testosterone levels in men from the overweight and obese groups were markedly decreased when compared with men in the normal weight group. In addition, the progressive motility, seminal plasma zinc concentration and spermatozoa acrosin activity were notably decreased in the obese group compared with the normal weight group. However, estradiol levels were significantly increased in the overweight, obese and underweight groups compared with the normal weight group. Notably, semen samples from obese males with astenospermia treated with 0–100 µmol/l resveratrol for 30 min demonstrated varying degrees of improvement in sperm motility. When these semen samples were treated with 30 µmol/l resveratrol, sperm motility improved when compared to other doses of resveratrol. Therefore, 30 µmol/l resveratrol was selected for further experiments. Upon treatment of semen samples with resveratrol (30 µmol/l) for 30 min, the seminal plasma zinc concentration and spermatozoa acrosin activity increased significantly in the experimental group compared with the control group. These data suggest that male obesity negatively impacts on male reproductive potential, not only through altering hormone levels, but also by directly altering sperm function. In addition, resveratrol may have a therapeutic and protective effect against obesity-induced abnormalities in semen.

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“…What is the best treatment for male mild subfertility? A Cochrane systematic review on male subfertility by Cissen et al [40] found similar pregnancy or live birth rates between IUI treatment and timed intercourse with or without ovarian stimulation. An RCT described by Bensdorp et al [41] revealed that IUI/COH induced comparable live birth rate to IVF in modified natural cycles or IVF with single embryo transfer.…”

Section: Diagnosis and Its Treatment Factorsmentioning

confidence: 99%

What is the optimal protocol for Intrauterine Insemination (IUI)? A Mini Review and A Retrospective Study to Evaluate Effective Factors Influencing Pregnancy after IUI

Herrero²,

Zhu

et al. 2019

Preprint

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Background: Although it is well documented on the study of intrauterine insemination (IUI), the effectiveness of various factors on IUI treatment is inconsistent. The aim of this study is to investigate the various factors that influence IUI outcome and attempt to set up optimal protocol for IUI patients. Methods: This was a retrospective cohort study including1948 cycles (843 couples) that performed IUI between January 2012 and December 2013 in a single centre. Various factors that may affect IUI outcome were analyzed using chi-square. Moreover, we conducted multiple logistic regression to evaluate the main factors on the effects of IUI outcome. In addition, follicle growth and endometrial development relevant to conception were also assessed among protocols. Results: The clinical pregnancy rate (CPR) per cycle was 12.5% in the present study. Seven factors were identified to be associated significantly with CPR by multivariate logistic regression analysis: female age, type of infertility, ovarian stimulation protocol, preovulatory follicles, endometrial thickness, growing length of preovulatory follicle, post-washed total motile spermatozoa count (TMSC). Comparing with 11 days or less, more than 15 days for ovarian response and endometrial development before insemination induced a better success rate. Although ovarian stimulation with gonadotrophin or letrozole induced higher CPR when comparing to stimulation with clomiphene citrate or without stimulation, ovarian stimulation with letrozole was superior to gonadotrophin by its similar CPR to gonadotrophin but lower follicle number, without the risk of multiple pregnancy. Women younger than 41 years with elevated endometrial thickness inseminated with TMSC ≥ 4.0 million had better chance to obtain pregnancy. Number of treatment cycle was not a factor to affect CPR, with a stable CPR in the first four cycles. Conclusions: We conclude that women no more than 41 years old are suitable to perform at least 4 cycles of IUI before proceeding to IVF. The optimized IUI treatment requires ovarian stimulation with letrozole to induce one/two follicles and fertilize with four or more million motile spermatozoa and an elevated endometrium on day 15 or after in the cycle. Key words: infertility, intrauterine insemination, effective factors, clinical pregnancy rate.

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Assisted reproductive technologies for male subfertility

Cited by 42 publications

References 113 publications

Longer time interval between semen processing and intrauterine insemination does not affect pregnancy outcome

Longer time interval between semen processing and intrauterine insemination does not affect pregnancy outcome

Protective effect of resveratrol on spermatozoa function in male infertility induced by excess weight and obesity

What is the optimal protocol for Intrauterine Insemination (IUI)? A Mini Review and A Retrospective Study to Evaluate Effective Factors Influencing Pregnancy after IUI

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