Assignment of the Y4Receptor Gene (PPYR1) to Human Chromosome 10q11.2 and Mouse Chromosome 14

Genome-wide association study suggested copy number variation may be associated with body mass index in the Chinese population

“…First, mice may not be the most appropriate model to understand the function of PPYR1 in human, as mice expressed a functional Y6 receptor and this receptor was also used to interpret receptor knockout results 27. Second, the mice PPYR1 amino acid sequence is 76% identical to human PPYR1 ;33 the highly variable PPYR1 across species may explain why its exact roles differ among species 27. Third, compared with the 597 studied subjects, PPYR1 knockout ( PPYR1 -/-) mice have neither copy of the gene nor corresponding gene expression products.…”

Molecular analysis of the neuropeptide Y1 receptor gene in human idiopathic gonadotropin-dependent precocious puberty and isolated hypogonadotropic hypogonadism

“…The genes encoding the NPY-Y1R and NPY-Y5R receptor subtypes are transcribed in opposite directions from a common promoter in a region of chromosome 4q31-32 and most likely evolved from a gene duplication event (28). Thus, a mutation in one of these receptors genes may have consequences on expression of the other gene.…”

Neuropeptide Y and Bone Regulation

“…35 Moreover, the conservation between human and mouse of Y4 receptor is also relatively low (76%) when compared against Y1 (94%) and Y2 (94%) receptors. 35 Moreover, the conservation between human and mouse of Y4 receptor is also relatively low (76%) when compared against Y1 (94%) and Y2 (94%) receptors.…”

“…35 Moreover, the conservation between human and mouse of Y4 receptor is also relatively low (76%) when compared against Y1 (94%) and Y2 (94%) receptors. 35 This site is critical to reception of neuronal signals from organs in the periphery, with an incomplete blood-brain barrier, permitting the entry of small peptide hormones. 35 Y4 receptor mRNA has been identified in the brainstem.…”

“…The Y4 receptor also shows a unique ligand binding profile, preferentially binding the NPY family ligand pancreatic polypeptide (PP). 35 In peripheral tissues, Y4 receptors are predominantly expressed in heart, gastrointestinal tract, skeletal muscle, pancreas, testis and uterus. In particular, there is a dense population of high-affinity Y4 receptors in the dorsal vagal complex of the brainstem.…”