Assignment of the NRAS protooncogene to chromosome 12 of Syrian hamster by in situ hybridization

Abstract

The NRAS protooncogene codes for a GTP binding/GTPase p21 protein which resides on the inner surface of the plasma mebrane. Using a human cDNA probe for NRAS, we have assigned the gene to Syrian hamster chromosome 12 with the most likely localization being 12qa5.

The RB gene locates on chromosome 15 at band 15q13 in the Syrian hamster

“…1986). Despite the extensive use of Syrian hamster cells, however, lit tle is known about the genetics of this species, especially the chromosomal locations of specific oncogenes and tumor sup pressor genes (Issa et al, 1992). In the present paper, we have determined the chromosomal location of the retinoblastoma (RB) gene in the Syrian hamster.…”

Assignment of TK1 encoding thymidine kinase to Syrian hamster chromosome 9 by microcell-mediated chromosome transfer

“…The diploid chromosome number is 44. and only seven linkage groups are known (Robinson 1990). Recently, the NRAS protooncogene has been assigned to MAUI2 by in situ hybridization (Issa et al 1992). So far.…”