Assessments of tumor metabolism with CEST MRI

Goldenberg, Joshua M.; Pagel, Mark

doi:10.1002/nbm.3943

Cited by 67 publications

(63 citation statements)

References 95 publications

(131 reference statements)

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“…Tumors typically display upregulated glucose uptake and glycolytic metabolism (55). In the clinical setting, PET imaging with the glucose analog FDG is considered the gold standard technique for non-invasively mapping glucose uptake and for assessing tumor response to conventional therapy (56).…”

Section: Imaging Glucosementioning

confidence: 99%

Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST Imaging

Consolino¹,

Anemone²,

Capozza³

et al. 2020

Front. Oncol.

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Altered metabolism is considered a core hallmark of cancer. By monitoring in vivo metabolites changes or characterizing the tumor microenvironment, non-invasive imaging approaches play a fundamental role in elucidating several aspects of tumor biology. Within the magnetic resonance imaging (MRI) modality, the chemical exchange saturation transfer (CEST) approach has emerged as a new technique that provides high spatial resolution and sensitivity for in vivo imaging of tumor metabolism and acidosis. This mini-review describes CEST-based methods to non-invasively investigate tumor metabolism and important metabolites involved, such as glucose and lactate, as well as measurement of tumor acidosis. Approaches that have been exploited to assess response to anticancer therapies will also be reported for each specific technique.

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Section: Imaging Glucosementioning

confidence: 99%

Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST Imaging

Consolino¹,

Anemone²,

Capozza³

et al. 2020

Front. Oncol.

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“…Its decrease over time reflects the ongoing production of cadaverine and yields a specific activity for LDC that agrees well with fluorescence measurements that also rely on displacement assays with CBs [ 468 ]. Other types of catalytic conversion have also been studied with 1 H NMR using the so-called catalyCEST approach [ 469 ]. The advantage of qHyperCEST is its very high sensitivity that enables following the process just at the very beginning when the conversion rate is still constant.…”

Section: Quantitative Analysis Of 129 Xe Host Smentioning

confidence: 99%

Molecular Sensing with Host Systems for Hyperpolarized 129Xe

Jayapaul

Schröder

2020

Molecules

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Hyperpolarized noble gases have been used early on in applications for sensitivity enhanced NMR. 129Xe has been explored for various applications because it can be used beyond the gas-driven examination of void spaces. Its solubility in aqueous solutions and its affinity for hydrophobic binding pockets allows “functionalization” through combination with host structures that bind one or multiple gas atoms. Moreover, the transient nature of gas binding in such hosts allows the combination with another signal enhancement technique, namely chemical exchange saturation transfer (CEST). Different systems have been investigated for implementing various types of so-called Xe biosensors where the gas binds to a targeted host to address molecular markers or to sense biophysical parameters. This review summarizes developments in biosensor design and synthesis for achieving molecular sensing with NMR at unprecedented sensitivity. Aspects regarding Xe exchange kinetics and chemical engineering of various classes of hosts for an efficient build-up of the CEST effect will also be discussed as well as the cavity design of host molecules to identify a pool of bound Xe. The concept is presented in the broader context of reporter design with insights from other modalities that are helpful for advancing the field of Xe biosensors.

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“…Amide proton transfer (APT) imaging is the most widely used CEST technique. APT imaging for cancer assessment has been mainly focused on the brain, but higher APT values have been found in malignant tumors compared with those in normal tissues and benign lesions in brain, breast, prostate, chest, and H&N. APT values also varied between malignant groups and tumor grades [67,68].…”

Section: Tissular Composition and Imagingmentioning

confidence: 99%

How clinical imaging can assess cancer biology

et al. 2019

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Human cancers represent complex structures, which display substantial inter-and intratumor heterogeneity in their genetic expression and phenotypic features. However, cancers usually exhibit characteristic structural, physiologic, and molecular features and display specific biological capabilities named hallmarks. Many of these tumor traits are imageable through different imaging techniques. Imaging is able to spatially map key cancer features and tumor heterogeneity improving tumor diagnosis, characterization, and management. This paper aims to summarize the current and emerging applications of imaging in tumor biology assessment.

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Assessments of tumor metabolism with CEST MRI

Cited by 67 publications

References 95 publications

Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST Imaging

Non-invasive Investigation of Tumor Metabolism and Acidosis by MRI-CEST Imaging

Molecular Sensing with Host Systems for Hyperpolarized 129Xe

How clinical imaging can assess cancer biology

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