Assessment the efficacy of some various treatment methods, in vitro and in vivo, against Aeromonas hydrophila infection in fish with regard to side effects and residues

El-Sherbeny, Eman M. El.; Khoris, Enas A.; Kassem, Samr

doi:10.1016/j.cbpc.2021.109246

Cited by 5 publications

(4 citation statements)

References 67 publications

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“…Infection with A. hydrophila severely affects fish farming and results in high mortality and economic loss [ 7 ]. However, the application of immunostimulants and functional additives, including algae extracts, limited the infection in aquaculture [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Abiotic and biotic farming systems can mainly induce oxidative stress followed by immunosuppression, thereby bringing about a high vulnerability to infection by pathogenic invaders [ 4 , 5 , 6 ]. A. hydrophila infection is a predominant pathogenic bacterium in carp farms that causes motile Aeromonas septicemia with high morbidity and mortality [ 7 ]. In case of infection, chemotherapies are usually prescribed to relieve the impacts of A. hydrophila infection on common carp [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Brown Seaweed (Padina australis) Extract can Promote Performance, Innate Immune Responses, Digestive Enzyme Activities, Intestinal Gene Expression and Resistance against Aeromonas hydrophila in Common Carp (Cyprinus carpio)

Sheikhzadeh

Ahmadifar

Soltani

et al. 2022

Animals

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Eight-week oral administration of Padina australis ethyl acetate extract at 100, 200, and 400 mg/kg diets was assessed on the growth performance, tight junction proteins, intestinal immunity, and disease resistance to Aeromonas hydrophila in common carp (Cyprinus carpio). A total of 300 healthy common carp weighing around 14.8 ± 0.03 g were randomly assigned into four equal groups within 12 glass aquariums, each in three replicates (25 fish/tank), for the feeding trial experiment. The first group served as the control group and was fed an un-supplemented diet, whilst the other three groups were offered diets containing graded amounts of Padina australis ethyl acetate extract at 100, 200, and 400 mg/kg, respectively. The growth indices, including final weight, length, weight gain rate, specific growth rate, and feed conversion ratio, were meaningfully improved in fish fed with the algae at 200 and 400 mg/kg compared to the control fish (p < 0.05). Similarly, digestive enzyme activities and serum immune parameters were significantly higher in all treatments, especially 200 and 400 mg/kg fed groups, compared to the control (p < 0.05). In parallel, significant upregulation of genes related to integrity and the immune system was shown in the intestine of these treatment groups compared to control fish (p < 0.05). When fish were challenged with A. hydrophila, the cumulative survival percentages were 53.3% (p = 0.215), 70.0 % (p = 0.009), and 76.7% (p = 0.002) in fish fed 100, 200, and 400 mg/kg diets, respectively, compared to 36.7% survival in control fish (p = 0.134). These data show that the eight-week dietary administration of P. australis extract to common carp can enhance growth performance, digestive enzyme activity, immune response, and disease resistance to A. hydrophila infection.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Brown Seaweed (Padina australis) Extract can Promote Performance, Innate Immune Responses, Digestive Enzyme Activities, Intestinal Gene Expression and Resistance against Aeromonas hydrophila in Common Carp (Cyprinus carpio)

Sheikhzadeh

Ahmadifar

Soltani

et al. 2022

Animals

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“…The role of CNPs as beneficial additives in fish feed, stimulating growth, boosting immune defenses, and reducing pathogenic bacterial proliferation in the gastrointestinal tract [8]. Previous research has revealed compelling evidence showcasing the bactericidal properties of chitosan nanoparticles (CNPs) against A. hydrophila bacteria [9]. This notable effect is ascribed to CNPs adhering to and disrupting bacterial cell walls, ultimately leading to cell lysis and death.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Adding Chitosan Nanoparticles Loaded with Sidr Leaf Extract (Ziziphus spina-christi) (CPNs SLE) in Diet on Pangasius sp. Infected Aeromonas hydrophila

Prayitno,

Aulia,

Chrisnawat

et al. 2024

Int J Chem Biochem Sci

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One of the bacterial types that affects freshwater fish is Aeromonas hydrophila. These bacteria cause the occurrence of Motile Aeromonas Septicemia (MAS) disease. This study investigates the impact and optimal dosage of chitosan nanoparticles (CNPs) loaded with sidr leaves extract (SLE) on clinical manifestations, growth, hematological parameters, and survival rates of Pangasius sp. infected A. hydrophila. The experimental design employed a Completely Randomized Design with five treatments and three replications, utilizing 150 fish with an average length of 7-9 cm. Treatments included the addition of 10 ppm tetracycline (K+) in the diet and CNPs SLE with concentrations A (0 ppm), B (450 ppm), C (500 ppm), and D (550 ppm). The results demonstrate that incorporating CNPs SLE into the diet yields beneficial effects on infected Pangasius sp., leading to faster recovery from clinical symptoms, enhanced growth rates, and increased survival rates of up to 85%. The optimal dosage of CNPs SLE for Pangasius sp. infected A. hydrophila in the feed is determined to be 500 ppm.

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“…Aeromonas Septicemia [MAS] which consider the most serious infectious disease in warm water aquaculture, in per acute phase the disease characterized by high mortality rates without any symptoms but in acute phase, ascites in the abdomen skin and fin ulcers clearly appeared on the external surface of fish with and exophthalmia in addition to presence of drug resistant mutants which increase the severity of the problem and significant losses in Egyptian aquaculture industry [10][11][12][13]. On the other hand, the use of antimicrobials in treatment has been proven leading to antimicrobial resistance, which is considered by the World Health Organization the one of the most dangerous risks to global health which has new expression as one health [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Use of Thyme and Thymol as Immunostimulant Agents to control Experimental ‎Aeromonas hydrophyla Infection in Nile Tilapia (Oreochromis niloticus)‎

Wassif

Mohammed

2022

Zagazig Veterinary Journal

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In the current investigation, a total of 110 Oreochromis niloticus were collected from aquaculture farm at Sahl Eltina area, North Sinai Governorate suffering from skin and fin ulcers with ascites, exophthalmia, and high mortalities. Aeromonas hydrophyla was isolated with a prevalence rate of 40% and identified biochemically. A. hydrophyla was used to induce experimental infection to Nile Tilapia in which thyme and thymol were used as feed additive. Evaluation of the protective effect of thyme and thymol as immunostimulant agents on fish tissue against experimental infection with Aeromonas infection was studied. A total of ninety apparently healthy fish tilapia were divided into three groups (GA, GB and GC of 30 fish per group) in triplicate. GA (infected non treated group) was fed on basal diet. GB and GC were fed on diet supplemented with Thyme vulgaris (10 g/ kg diet) and Thymol (3 g/ kg diet), respectively for 8 weeks and then the groups were subjected to experimental infection with Aeromonas hydrophyla isolate. The thyme and thymol groups had a nearly similar significant immunostimulant effect than infected non treated group by using lysozyme activity assay. Sever hyperemia of gill filaments and gill arch, epithelial desquamation of the gill filament, enteritis, necrosis and desquamation of epithelial cells of intestine, muscle necrosis, myocardiolysis of heart, hydropic degeneration of liver and hemosiderosis of spleen were observed in infected non treated group. In the treated groups, the prophylactic effect of thyme and thymol on fish tissues were clear against experimental infection with A. hydrophyla. These results indicate that the using thyme or thymol as feed additive could enhance the immunity and protect fish tissues from pathological deterioration induced by infection with Aeromonas hydrophila which is considered as one the main fish pathogens in Egypt.

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Assessment the efficacy of some various treatment methods, in vitro and in vivo, against Aeromonas hydrophila infection in fish with regard to side effects and residues

Cited by 5 publications

References 67 publications

Brown Seaweed (Padina australis) Extract can Promote Performance, Innate Immune Responses, Digestive Enzyme Activities, Intestinal Gene Expression and Resistance against Aeromonas hydrophila in Common Carp (Cyprinus carpio)

Brown Seaweed (Padina australis) Extract can Promote Performance, Innate Immune Responses, Digestive Enzyme Activities, Intestinal Gene Expression and Resistance against Aeromonas hydrophila in Common Carp (Cyprinus carpio)

The Effect of Adding Chitosan Nanoparticles Loaded with Sidr Leaf Extract (Ziziphus spina-christi) (CPNs SLE) in Diet on Pangasius sp. Infected Aeromonas hydrophila

Use of Thyme and Thymol as Immunostimulant Agents to control Experimental ‎Aeromonas hydrophyla Infection in Nile Tilapia (Oreochromis niloticus)‎

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