Assessment ofTakotsubo (ampulla) cardiomyopathy using99mTc-tetrofosmin myocardial SPECT —Comparison with acute coronary syndrome—

Abstract

Impaired coronary microcirculation might be a causative mechanism of Takotsubo cardiomyopathy.

Transient left ventricular dysfunction (tako-tsubo phenomenon): Findings and potential pathophysiological mechanisms

“…One argument against this includes the observation that left ventricular dysfunction in TTP is not confined to the supply area of one coronary artery. Microvascular spasm is another possible mechanism for inducing myocardial ischemia in TTP (52,64,(70)(71)(72)(73). Investigations of TTP patients with technetium-99m tetrofosmin myocardial single photon emission computed tomography have documented a decreased uptake during the acute phase of TTP, suggesting that impaired coronary microcirculation may play a role in TTP (21,52,64,70).…”

Characteristics of coronary microcirculatory function in patients with Takotsubo syndrome

“…Kume et al detected the dysfunction of the coronary microcirculation with Doppler flow-wire technique in patients with TS (19). Other authors demonstrated, in patients with TS, abnormalities of the microcirculation through myocardial perfusion scintigraphy with technetium 99 m tetrofosmin (20)(21)(22). A disorder of glucose and fatty acid metabolism, even more, severe of the perfusion defect, has also been demonstrated (23)(24).…”

Mechanisms of Takotsubo cardiomyopathy; role of microcirculatory dysfunction

“…[1][2][3][4][5][6][7][8][9][10][11][12][13] Several invasive and non-invasive modalities have been utilized to assess myocardial perfusion both during the acute and recovery phase of TCM. 8,9,[14][15][16][17][18][19][20][21][22][23] These techniques include Doppler guidewire technique, Thrombolysis In Myocardial Infarction (TIMI) frame count (TFC) and TIMI myocardial perfusion grade (TMPG) calculation. 8,9,[14][15][16][17][18][19][20][21][22][23] Gibson et al introduced a novel method in 1996 called 'TIMI frame count' for measuring coronary flow velocity from coronary angiograms.…”

“…8,9,[14][15][16][17][18][19][20][21][22][23] These techniques include Doppler guidewire technique, Thrombolysis In Myocardial Infarction (TIMI) frame count (TFC) and TIMI myocardial perfusion grade (TMPG) calculation. 8,9,[14][15][16][17][18][19][20][21][22][23] Gibson et al introduced a novel method in 1996 called 'TIMI frame count' for measuring coronary flow velocity from coronary angiograms. [8][9][10] Since then TFC has been used as a quantitative index to determine microcirculatory function in patients with acute coronary syndrome after primary coronary angioplasty as a predictor of functional recovery.…”

“…[17][18][19][20][21] Kume et al recorded coronary flow velocity spectrum and coronary flow velocity reserve (CFVR) by using Doppler guidewire technique in the acute phase and three weeks later in the three main coronary vessels along with assessment of deceleration time of diastolic velocity (DDT). 17 They noted that both the CFVR and DDT decreased during the acute phase of the illness with normalization noted at three weeks.…”