Assessment of vitamin D receptors in alopecia areata and androgenetic alopecia

Fawzi, May; Mahmoud, Sara; Ahmed, Shereen Fathi; Shaker, Olfat G.

doi:10.1111/jocd.12224

Cited by 33 publications

(41 citation statements)

References 26 publications

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“…Fawzi et al have shown that there is decreased expression of tissue and serum VDR by ELISA in patients of AA, and androgenetic alopecia as compared to controls; they also found a negative correlation of tissue VDR and extent of AA. In our study, also, we did not find any correlation between extent of AA and VDR expression in lesional tissue.…”

Section: Discussionmentioning

confidence: 99%

Correlation of vitamin D and vitamin D receptor expression in patients with alopecia areata: a clinical paradigm

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Correlation of vitamin D and vitamin D receptor expression in patients with alopecia areata: a clinical paradigm

et al. 2017

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“…Some have specifically examined the role of the VDR. Fawzi et al recently found lower levels of the VDR in serum and scalp tissue samples in AA patients compared to controls [42]. Polymorphisms of the VDR gene have been shown to increase susceptibility to other autoimmune diseases, including Graves’ disease and psoriasis [45, 46].…”

Section: Micronutrientsmentioning

confidence: 99%

The Role of Micronutrients in Alopecia Areata: A Review

et al. 2017

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Alopecia areata (AA) is a common, non-scaring form of hair loss caused by immune-mediated attack of the hair follicle. As with other immune-mediated diseases, a complex interplay between environment and genetics is thought to lead to the development of AA. Deficiency of micronutrients such as vitamins and minerals may represent a modifiable risk factor associated with development of AA. Given their role in normal hair follicle development and in immune cell function, a growing number of investigations have sought to determine whether serum levels of these nutrients might differ in AA patients, and whether supplementation of these nutrients might represent a therapeutic option for AA. While current treatment often relies on invasive steroid injections or immunomodulating agents with potentially harmful side-effects, therapy by micronutrient supplementation, whether as a primary modality or as adjunctive treatment, could offer a promising low-risk alternative. However, our review highlights a need for further research in this area, given that the current body of literature largely consists of small case-control studies and case-reports which preclude any definite conclusions for a role of micronutrients in AA. In this comprehensive review of the current literature we found that serum vitamin D, zinc, and folate levels tend to be lower in patients with AA as compared to controls. Evidence is conflicting or insufficient to suggest differences in levels of iron, vitamin B12, copper, magnesium, or selenium. A small number of studies suggest that vitamin A levels may modify the disease. Though understanding of the role for micronutrients in AA is growing, definitive clinical recommendations such as routine serum level testing or therapeutic supplementation, call for additional studies in larger populations and with a prospective design.

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“…reported significantly decreased serum ferritin and serum vitamin D 2 levels in 80 women with either chronic telogen effluvium or FPHL compared to 40 age‐matched healthy females. Fawzi et al . observed decreased serum and tissue levels of vitamin D receptors (VDRs) in 20 patients with AGA.…”

Section: Aetiologymentioning

confidence: 99%

Genetics and other factors in the aetiology of female pattern hair loss

Redler

Messenger

Betz

2017

Experimental Dermatology

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Pattern hair loss is the most common form of hair loss in both women and men. Male pattern hair loss, also termed male androgenetic alopecia (M-AGA), is an androgendependent trait that is predominantly genetically determined. Androgen-mediated mechanisms are probably involved in female pattern hair loss (FPHL) in some women but the evidence is less strong than in M-AGA; other non-androgenic pathways, including environmental influences, may contribute to the aetiology. Genome-wide association studies have identified several genetic loci for M-AGA and have provided better insight into the underlying biology. However, the role of heritable factors in and it has long been assumed that FPHL shares the same aetiology;hence, the term "female androgenetic alopecia" is often applied to this condition. However, the role of androgens in causing FPHL is less clear than in men. The genetic studies performed so far have not led to any firm conclusions but rather suggest different pathways for M-AGA and FPHL.In this review, we summarize what is known about the aetiology of FPHL and its relationship to M-AGA. Our main focus is on the results of genetic studies performed within the last decade. We also discuss the role of endocrine and other factors in the pathogenesis. | PREVALENCEPublished data on the prevalence of FPHL show some variation between studies, perhaps reflecting the difficulty in classifying mild forms of the condition. However, all show an increasing prevalence with age. Studies in women of white European ethnicity in the USA, [2] UK [3] and Australia [4] record a prevalence of 3%-12% in the third decade, rising to 14%-28% in the sixth decade and 29%-56%

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Assessment of vitamin D receptors in alopecia areata and androgenetic alopecia

Abstract: This study suggests an important role for VDR in the pathogenesis of AA and AGA through documenting lower serum and tissue VDR levels in AA and AGA patients in comparison with controls.

Cited by 33 publications

References 26 publications

Correlation of vitamin D and vitamin D receptor expression in patients with alopecia areata: a clinical paradigm

Correlation of vitamin D and vitamin D receptor expression in patients with alopecia areata: a clinical paradigm

The Role of Micronutrients in Alopecia Areata: A Review

Genetics and other factors in the aetiology of female pattern hair loss

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