Assessment of the wettability of powders by use of compressed powder discs

Buckton, Graham; Newton, JM

doi:10.1016/0032-5910(86)80027-4

Cited by 91 publications

(37 citation statements)

References 12 publications

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“…Investigators apply different forces to compact the powder, which can give rise to changes in the structure properties such as fragmentation, amorphicity, capillary forces, porosity, etc. Difference in compression force can affect the value of the contact angle by as much as 40 • [11]. Furthermore, measurements on a single crystal of paracetamol have been made by Heng et al, showing that the contact angle of different sides of the crystal differs significantly [12].…”

Section: Introductionmentioning

confidence: 97%

Nucleation and crystal growth in supersaturated solutions of a model drug

Lindfors¹,

Forssén²,

Westergren³

et al. 2008

Journal of Colloid and Interface Science

218

194

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Section: Introductionmentioning

confidence: 97%

Nucleation and crystal growth in supersaturated solutions of a model drug

Lindfors¹,

Forssén²,

Westergren³

et al. 2008

Journal of Colloid and Interface Science

218

194

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“…A rough surface may increase the interfacial contact area between the ® lm and the tablet substrate, resulting in a higher adhesion force, although Khan et al (2001) found there to be an increase in ® lm adhesion at high compression pressures, where the surface should be smoother. This may have been a result of a change in substrate surface energy at high compression pressures as previously suggested by Buckton & Newton (1986).…”

Section: Predictions Based On the Physicochemical Properties Of Raw Mmentioning

confidence: 59%

Predictive and correlative techniques for the design, optimisation and manufacture of solid dosage forms

Hardy

Cook

2003

Journal of Pharmacy and Pharmacology

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There is much interest in predicting the properties of pharmaceutical dosage forms from the properties of the raw materials they contain. Achieving this with reasonable accuracy would aid the faster development and manufacture of dosage forms. A variety of approaches to prediction or correlation of properties are reviewed. These approaches have variable accuracy, with no single technique yet able to provide an accurate prediction of the overall properties of the dosage form. However, there have been some successes in predicting trends within a formulation series based on the physicochemical and mechanical properties of raw materials, predicting process scale-up through mechanical characterisation of materials and predicting product characteristics by process monitoring. Advances in information technology have increased predictive capability and accuracy by facilitating the analysis of complex multivariate data, mapping formulation characteristics and capturing past knowledge and experience.

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“…As polymer powder is used in the coating process it would be desirable to investigate the spreading behavior of different additives on the powder. However, it is not possible to obtain reliable results with measurements on powders using the sessile drop method due to the roughness of the powder bed's surface (Buckton and Newton, 1986). Indirect measurements on powders like liquid penetration techniques (Washburn method) have several drawbacks described in literature (Buckton and Newton, 1985;Carli and Simioni, 1979).…”

Section: Contact Angle Measurementsmentioning

confidence: 99%