Impact of excipients on coating efficiency in dry powder coating

Smikalla, M.; Mescher, Axel; Walzel, Peter; Urbanetz, Nora Anne

doi:10.1016/j.ijpharm.2010.12.001

Cited by 29 publications

(12 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Figure 6 shows the dissolution profile of AAP from samples produced by one-step or two-step addition of CW (Rp. 8,9). The one-step processing was performed that all components was added and processed in the mechanofusion for 10 min at the specified condition after pre-processing.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, many solventless coating technologies have been reported 4 . Concerning dry powder coating, some researchers reported a system in which the coating polymer and the binder/plasticizer solution are fed directly to the core particle [5][6][7][8][9] . In such a system, a small amount of water and a curing step are required to promote film…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Solventless dry powder coating for sustained drug release using mechanochemical treatment based on the tri-component system of acetaminophen, carnauba wax and glidant

Hoashi¹,

Tozuka²,

Takeuchi³

2012

Drug Development and Industrial Pharmacy

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Solventless dry powder coating for sustained drug release using mechanochemical treatment based on the tri-component system of acetaminophen, carnauba wax and glidant

Hoashi¹,

Tozuka²,

Takeuchi³

2012

Drug Development and Industrial Pharmacy

View full text Add to dashboard Cite

show abstract

“…It is a green and environmentally friendly process requiring no solvent and is free of any process by-products. Furthermore, the process involves energy saving since there is no drying process [17,23,24,29,48]. Some devices where milling is concurrently carried out with coating, there is a reduction in the risk of contamination as there is no milling medium required [49].…”

Section: Advantages Of Dry Powder Coating Techniquementioning

confidence: 99%

Functionalised particles using dry powder coating in pharmaceutical drug delivery: promises and challenges

Dahmash

Mohammed

2015

Expert Opinion on Drug Delivery

View full text Add to dashboard Cite

Dry particle coating is a promising solvent-free manufacturing technology to produce particles with targeted functionalities. Progress within this area requires the development of continuous processing devices that can overcome challenges encountered with current technologies such as heat generation and particle attrition. Growth within this field requires extensive research to further understand the impact of process design and material properties on resultant functionalities.

show abstract

“…6,7 Among these solvent-less coating technologies, dry-polymer coating has been successful in modified-release applications of APIs including that of delayed and extended release as well as taste masking. [13][14][15][16][17][18][19] Dry-polymer coating, more accurately referred to as plasticizer-dry-polymer coating, is a method by which micronized polymer (dry powder) and small amounts of liquid plasticizers are simultaneously sprayed and layered onto a substrate (e.g., granule or tablet), typically performed in shear-based mixers or fluidized beds. Plasticizers are used in order to provide a temporary capillary force to ensure strong adhesion of the micronized polymer to the substrate.…”

Section: Introductionmentioning

confidence: 99%