Assessment of the Rigidity Changes of Corpus Cavernosum Penis in Vasculary Erectile Dysfunction (<scp>ED</scp>) Subtypes by Shear Wave Elastography (<scp>SWE</scp>)

Aybar, Mustafa Devran; Turna, Önder

doi:10.1002/jum.15741

Cited by 5 publications

(9 citation statements)

References 23 publications

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“…25 Therefore, blood perfusion of CCP is inadequate in patients with vascular ED, whereas it is normal in patients with non-vascular ED. This may explain why the SWE value of CCP in the erectile state was signi cantly higher in the vascular ED group than in the non-vascular ED group, which is similar to the results of studies conducted by Zhou et al, 10 Aybar et al, 23 and Cui et al 20 Comparing vascular ED in accid state to non-vascular ED in accid state, the mean SWE value was signi cantly higher in vascular ED, matching the results of similar studies. 23,26 We speculate that irrespective of the accid or erectile state, the vascular lesion of the penis does not change, and therefore the blood perfusion of CCP remains insu cient in vascular ED.…”

Section: Discussionsupporting

confidence: 89%

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The use of shear wave elastography in the diagnosis of erectile dysfunction: a feasibility study

Zhang,

Li,

Guan

et al. 2023

Preprint

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The aim of this study was to explore the value of SWE in evaluating vascular and nonvascular erectile dysfunction. In this study, ED patients enrolled (n = 114) received SWE and PCUD exams. The PSV and EDV were used as the classification standard. The performance of the SWE was assessed with the receiver operating characteristic curve, sensitivity and specificity. The rigidity alterations of corpus cavernosum penis with age was also investigated. SWE values of CCP before ICI negatively correlated with age of patients in vascular ED group (r = -0.288, P<0.05). In erectile or flaccid state, the SWE value of vascular ED was significantly larger than non-vascular ED. When the cut-off value for SWE values of CCP 0.88 m/s in erectile state and 2.32 m/s in flaccid state, the areas under the ROC curve were 0.700 (sensitivity: 77.78%, specificity: 60.00%) and 0.612(sensitivity: 68.52%, specificity: 51.67%) in erectile or flaccid state, respectively. This study provides preliminary evidence that SWE in flaccid state could be non-invasive methods used to moderate predict vascular ED.

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Section: Discussionsupporting

confidence: 89%

“…Currently, SWE values of CCP are primarily derived from blood ow. 10,23 However, SWE values obtained from uid sections are signi cantly lower than those obtained from solid tissues. 16 Consequently, the SWE value of CCP was signi cantly higher before ICI than after ICI, which is similar to previous studies.…”

Section: Discussionmentioning

confidence: 97%

The use of shear wave elastography in the diagnosis of erectile dysfunction: a feasibility study

Zhang,

Li,

Guan

et al. 2023

Preprint

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“…Besides, 2D-SWE is a reliable technique with high specificity and sensitivity for quantitative assessment of the elastic characteristics in the penile tissue [ 10 , 11 ]. The SWQ value is correlated with the International Index of Erectile Function (IIEF-5) and Erection Hardness Scale (EHS) scores [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Factors affecting the shear wave elastic quantitative measurement of penile tissue in rats

2023

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Background: As a new ultrasound technology, 2-dimensional shear wave elastography (2D-SWE) can evaluate the elastic characteristics of penile tissue. However, no studies have reported the main factors affecting the shear wave elastic quantitative measurement (SWQ) in penile tissue. Objectives: To analyze the main factors affecting the SWQ reflecting the elastic characteristics of penile tissue by 2D-SWE. Methods: Twenty healthy male Sprague–Dawley rats (5–60 weeks old) were selected for this study. We performed the 2D-SWE examination on the penis using the Aixplorer ultrasound system, with SWQ as the measurement index. We performed penile immunohistochemistry analysis with the positive area proportion (PAP) of alpha-smooth muscle actin (PAPS) and type III collagen fiber (PAPC) as the outcomes. Then, we conducted multiple linear regression analysis to explore the correlation of SWQ with PAPS and PAPC and established the regression equation. Results: The multiple linear regression analysis showed that the linear regression equation (SWQ = 10.376 – 0.05 PAPS – 0.07 PAPC) was statistically significant (F = 21.153, P < 0.001). The content of smooth muscle cells (SMCs) and collagen fibers was negatively correlated with SWQ, affecting 42.6% of the total variation in SWQ (R 2 = 0.426). Conclusions: SMCs and collagen fibers are the main factors affecting the SWQ value of penile tissue and the primary tissue components determining the SWQ when using 2D-SWE to quantitatively evaluate the elastic characteristics of penile tissue.

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“…SWE examination was performed as described previously. 11 12 13 14 15 16 17 18 Briefly, an Aixplorer ultrasonic system (Aixplorer Supersonic Imagine, Aix-en-Provence, France) with a Superlinear SL15-4 probe (frequency range of 7.5–15 MHz; mechanical index [MI]: 1.5; thermal index of soft tissue [TIS]: 1.2) was utilized. The participants were positioned supine on the examination bed.…”

Section: Methodsmentioning

confidence: 99%

“…These waves are detected by the transducer, and their speed is used to calculate the Young’s modulus (YM) of the tissue, which is directly related to its stiffness. 11 12 13 14 15 16 17 18 Our hypothesis is that SWE will be able to assess the degree of aging of the CCs. In the current study, we measured the YM of the CC (CCYM) by SWE in men in different age groups and explored the histological changes in the CC with aging.…”

Section: Introductionmentioning

confidence: 99%

Quantitative assessment of the aging corpus cavernosum by shear wave elastography

Ruan¹,

Yang²,

Cheng³

et al. 2022

Asian Journal of Andrology

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We wanted to determine whether shear wave elastography (SWE) could be used to evaluate the aging degree of the corpus cavernosum (CC) and to identify the histological basis of changes in SWE measurements during the aging process. We performed a cross-sectional study enrolling healthy participants of different ages. We measured the Young’s modulus (YM) of the penile CCs by SWE and assessed erectile function using the International Index of Erectile Function-5 (IIEF-5). Histological investigation was performed in surgically resected penile specimens from a separate group of patients to examine the smooth muscle and collagen content of the CCs. Furthermore, we measured the YM, erectile function, smooth muscle, and collagen content of the CCs in different age groups of rats. Finally, we enrolled 210 male volunteers in this study. The YM of the CC (CCYM) was positively correlated with age ( r = 0.949, P < 0.01) and negatively correlated with erectile function ( r = −0.843, P < 0.01). Histological examinations showed that CCs had increased collagen content but decreased smooth muscle content with increased age. The same positive correlation between CCYM and age was also observed in the animal study. In addition, the animal study showed that older rats, with increased CCYM and decreased erectile function, had lower smooth muscle content and higher collagen content. SWE can noninvasively and quantitatively evaluate the aging degree of the CC. Increased collagen content and decreased smooth muscle content might be the histological basis for the effect of aging on the CC and the increase in its YM.

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Assessment of the Rigidity Changes of Corpus Cavernosum Penis in Vasculary Erectile Dysfunction (ED) Subtypes by Shear Wave Elastography (SWE)

Cited by 5 publications

References 23 publications

The use of shear wave elastography in the diagnosis of erectile dysfunction: a feasibility study

The use of shear wave elastography in the diagnosis of erectile dysfunction: a feasibility study

Factors affecting the shear wave elastic quantitative measurement of penile tissue in rats

Quantitative assessment of the aging corpus cavernosum by shear wave elastography

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