Assessment of the nutrient intake and micronutrient status in the first trimester of pregnant women in Jakarta

Wibowo, Noroyono; Bardosono, Saptawati; Irwinda, Rima; Syafitri, Inayah; Putri, Atikah S.; Prameswari, Natasya

doi:10.13181/mji.v26i2.1617

Cited by 16 publications

(27 citation statements)

References 16 publications

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“…Both groups had concentration of serum zinc and 25(OH)D below normal range as well as serum copper above normal range. The concentration of zinc and 25(OH)D corresponds to another study in Indonesia that as much as 81.2% of its population have zinc deficiency and 99.6% have 25(OH)D deficiency [14]. Currently there is no reference of normal value for placental and cord blood concentration of trace elements as well as serum AtRA concentration.…”

Section: Resultsmentioning

confidence: 86%

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The Concentration of Micronutrients and Heavy Metals in Maternal Serum, Placenta, and Cord Blood: A Cross-Sectional Study in Preterm Birth

Irwinda

Wibowo

Putri

2019

Journal of Pregnancy

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Background Preterm birth is still a global burden particularly in Indonesia. The suboptimal concentration of certain micronutrients and heavy metals is hypothesized to play a role in the mechanism of preterm birth. Objective This study aimed to analyze the micronutrients and heavy metals concentrations between subjects with term and preterm birth. Design A cross-sectional study was conducted during January–June 2017 in Cipto Mangunkusumo Hospital and Budi Kemuliaan Hospital, Jakarta, Indonesia. Subjects were divided into term and preterm birth groups. The measured outcomes were maternal serum, placental, and blood cord concentration of zinc, copper, iron, selenium, manganese, mercury, lead, AtRA, and 25(OH)D. Results A total of 51 pregnant women participated in this study. Term group had higher concentration of maternal serum AtRA (0.22 ± 0.07 ng/mL versus 0.12 ± 0.03 ng/mL, p <0.001), higher placental concentration of manganese {0.99 (0.38 – 1.78) μg/g versus 0.42 ± 0.18 μg/g, p <0.001}, iron (252.16 ± 170.61 μg/g versus 78.45 ± 51.73 μg/g, p <0.001), copper {2.96 ± 1.80 μg/g versus 1.62 (0.70 – 3.88) μg/g, p 0.019}, zinc {58.34 (27.88 – 124.05) μg/g versus 28.41 (1.46 – 137.69) μg/g, p 0.011}, selenium (0.31 ± 0.31 ng/g versus 0.14 ± 0.20 ng/g, p 0.024), AtRA {21.7 ± 10.69 ng/g versus 0.7 (0.42 – 5.10) ng/g, p <0.001}, and 25(OH)D {75.84 ± 45.12 ng/g versus 18.00 (5 – 88) ng/g, p <0.001}, lower placental concentration of mercury (0.20 ± 0.17 ng/g versus 20.47 ± 41.35 ng/g, p 0.019) and lead (0.02 ± 0.01 ng/g versus 0.81 ± 1.43 ng/g, p 0.009), and higher cord blood concentration of copper {32.20 (16.30 – 69.60) μg/dL versus 20.60 (5.80 – 53.30) μg/dL, p 0.006} and AtRA (0.16 ± 0.04 versus 0.07 ± 0.01, p <0.001). Conclusion Preterm birth is associated with lower concentrations of micronutrients which play a role in antioxidant mechanism, as well as higher concentration of mercury and lead.

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Section: Resultsmentioning

confidence: 86%

“…Not only beneficial to bone metabolism, vitamin D along with its derivatives plays a role in immune system, particularly innate immune response. Deficiency in vitamin D is associated with poor pregnancy outcomes including intrauterine growth restriction and preterm birth [14].…”

Section: Resultsmentioning

confidence: 99%

The Concentration of Micronutrients and Heavy Metals in Maternal Serum, Placenta, and Cord Blood: A Cross-Sectional Study in Preterm Birth

Irwinda

Wibowo

Putri

2019

Journal of Pregnancy

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“…Indonesia is a tropical country with abundant sun exposure, as it lies within the equatorial zone. However, low vitamin D status is still found in such countries Several studies on vitamin D status in pregnant women and women of childbearing age have been conducted and have shown that an average of more than 95% of individuals have low vitamin D status [1–3].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency status and its related risk factors during early pregnancy: a cross-sectional study of pregnant Minangkabau women, Indonesia

Aji

Erwinda

Yusrawati

et al. 2019

BMC Pregnancy Childbirth

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Background Vitamin D deficiency (VDD) is a common problem in reproductive-aged women and has become a major public health problem worldwide. The effect of VDD in pregnancy has been associated with several adverse pregnancy outcomes. This study aims to assess the serum levels of 25-hydroxyvitamin D (25(OH)D) in the first trimester and its associated factors (socio-demographics, pregnancy profiles, dietary intake, and maternal anthropometry measurements) for the determination of vitamin D deficiency status in early pregnancy. Methods A cross-sectional study of 239 pregnant mothers in West Sumatra, Indonesia was conducted. We measured lifestyle, socio-demographics and pregnancy profile through a structured questionnaire and interview process. A semi quantitative-food frequency questionnaire (SQ-FFQ) was used to analyse the dietary intake of the pregnant women. Serum 25(OH)D concentrations were measured at < 13 weeks gestation using ELISA and logistic regression models were employed to identify the predictors of low vitamin D status. Results The prevalence of first-trimester maternal VDD and sufficiency were 82.8 and 17.2% respectively. The median 25(OH)D was 13.15 ng/mL (3.00–49.29 ng/mL). The significant independent predictors were no working status (OR: 0.029;0.001–0.708) ( p = 0.030); nulliparous parity status (OR: 7.634;1.550–37.608) ( p = 0.012); length of outdoor activity status of less than an hour (OR: 9.659;1.883–49.550) ( p = 0.007); and no consumption of supplements before pregnancy (OR: 4.49;1.081–18.563) ( p = 0.039). Conclusions The prevalence of VDD is common in early pregnancy among Minangkabau women. Recommendations and policies to detect and prevent such insufficiency during pregnancy should be developed by considering the associated factors.

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“…A study conducted in the same setting as our present study (Yogyakarta) detected vitamin D deficiency in 90% of cord blood samples ( 24 ). Two others studies conducted in two different places in Indonesia found that the prevalence of vitamin D deficiency in early pregnancy was very high, namely in Minangkabau: 82.8% and in Jakarta: 99.6% ( 9 , 10 ). A study in Korea observed that in winter, maternal low vitamin D status resulted in a marked reduction in WB BMC of the newborn ( 25 ).…”

Section: Discussionmentioning

confidence: 96%

“…Research in seven Asian countries that aimed to assess bone health using heel ultrasound in adults aged 46–85 years indicated that Indonesian men and women had the poorest bone health ( 8 ). In addition, it was obvious that most pregnant women in Indonesia were Vitamin D deficient even though they live in a tropical country where sun exposure was abundant ( 9 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

Maternal and Neonatal Factors Affecting Bone Mineral Content of Indonesian Term Newborns

et al. 2021

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Background: Interactions between the genome and intrauterine environment can affect bone mineralization in newborns and even in adult life. Several studies show that intrauterine fetal bone mineralization or early postnatal bone condition influences the risk of osteoporosis in later life.Objectives: To determine whole body bone mineral content (WB BMC) and factors that influence neonatal WB BMC in Indonesian term newborns.Subjects/Methods: A cross-sectional study was conducted in Dr. Sardjito General Hospital, Yogyakarta, Indonesia. A total of 45 term, appropriate for gestational age (AGA) newborns were included in this study. BMC was assessed by dual-energy x-ray absorptiometry (DXA) in the first week of life. Weight (g), length (cm) and head circumference (cm) were measured at birth. Data on maternal characteristics were obtained from the maternal health records or reported by the mothers.Results: WB BMC measured in the present study (mean ± SD: 33.2 ± 9.3 g) was lower than WB BMC of similar populations in developed countries. Multiple linear regression showed that birth weight, birth length, and gestational age had a positive association with WB BMC (p = 0.048, 0.017, and <0.001, respectively), while maternal cigarette exposure had a negative association with WB BMC (p = 0.012). Male infants had significantly higher of WB BMC than female (p = 0.025). These determinants contribute to 55% variability of WB BMC.Conclusions: WB BMC in Indonesian term newborns is lower than populations in developed countries. Birth weight, length, gestational age, sex, and maternal cigarette exposure during pregnancy are significantly associated with WB BMC observed in Indonesian newborns.

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Assessment of the nutrient intake and micronutrient status in the first trimester of pregnant women in Jakarta

Cited by 16 publications

References 16 publications

The Concentration of Micronutrients and Heavy Metals in Maternal Serum, Placenta, and Cord Blood: A Cross-Sectional Study in Preterm Birth

The Concentration of Micronutrients and Heavy Metals in Maternal Serum, Placenta, and Cord Blood: A Cross-Sectional Study in Preterm Birth

Vitamin D deficiency status and its related risk factors during early pregnancy: a cross-sectional study of pregnant Minangkabau women, Indonesia

Maternal and Neonatal Factors Affecting Bone Mineral Content of Indonesian Term Newborns

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