Assessment of the in vitro antimicrobial activity of Lactobacillus species for identifying new potential antibiotics

Dubourg, G; Elsawi, Ziena; Raoult, Didier

doi:10.1016/j.ijantimicag.2015.05.011

Cited by 25 publications

(13 citation statements)

References 17 publications

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“…Thus, as it has been stated that L. rhamnosus presents an ample antimicrobial potential (Dubourg et al, 2015), it was expected that, when interacting with E. faecalis, L. rhamnosus would interfere with its growth and harmed the biofilm formation. However, with the methodology used in this research, L. rhamnosus not only did not inhibit the growth of E. faecalis in biofilm, but also enhanced its growth.…”

Section: Resultsmentioning

confidence: 99%

Relationship between the probiotic Lactobacillus rhamnosus and Enterococcus faecalis during the biofilm formation

Montecinos¹,

Jofre²,

Amêndola³

et al. 2016

Afr. J. Microbiol. Res.

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One of the factors that make the treatment of Enterococcus faecalis infections difficult is their ability to form biofilm, as well as their natural and acquired resistance to antibiotics which does not have specific drugs for their inhibition. This fact makes essential the search for alternative treatments, as the use of probiotics strains of Lactobacillus rhamnosus has been effective in the treatment of some diseases. In this investigation, the relationship between the probiotic strain of L. rhamnosus and E. faecalis during the biofilm formation was analyzed. Standardized suspensions used in biofilm development and treatment in different stages of the biofilm formation were prepared. The L. rhamnosus suspension was placed in contact for 90 min with E. faecalis freshly created biofilms (initial adherence) in the 24 h biofilms. The same was made with E. faecalis suspension on L. rhamnosus biofilms. L. rhamnosus showed no inhibitory effects on E. faecalis biofilms formation, with an increase in the counting of colony forming units in the treated groups (p=0.0047, p=0.0060). About the L. rhamnosus biofilms, there was no significant difference for both treatment stages. The probiotic strain interfered in vitro with the E. faecalis biofilm formation, thereby intensifying the growth of E. faecalis biofilm.

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Section: Resultsmentioning

confidence: 99%

Relationship between the probiotic Lactobacillus rhamnosus and Enterococcus faecalis during the biofilm formation

Montecinos¹,

Jofre²,

Amêndola³

et al. 2016

Afr. J. Microbiol. Res.

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“…Gene modification techniques have gained significant strength in this particular field as it allows combining natural features of certain microorganisms and fungi with the insertion of genes coding for the metabolism of given antibiotics [32]. Research in this aspect has opened the field going from bioinformatics-used for the identification of specific gene clusters that can metabolize compounds [33]-to genetic modification and inclusion of new metabolic features on microorganisms-for the production of antibiotics and up to the testing of new compounds for their biocide activity [34]. In addition, in order to overcome the barriers (e.g., structural complexity) posed by the chemical modification of natural products derived from fermentation, research has also focused on developing complete synthesis routes for the production of antibiotics [35].…”

Section: Antibioticsmentioning

confidence: 99%

A Review on the Feedstocks for the Sustainable Production of Bioactive Compounds in Biorefineries

Serna-Loaiza

Miltner

et al. 2019

Sustainability

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Since 2015, the sustainable development goals of the United Nations established a route map to achieve a sustainable society, pushing the industry to aim for sustainable processes. Biorefineries have been studied as the technological scheme to process integrally renewable resources. The so-called “bioactive” compounds (BACs) have been of high interest, given their high added value and potential application in pharmaceutics and health, among others. However, there are still elements to be addressed to consider them as economic drivers of sustainable processes. First, BACs can be produced from many sources and it is important to identify feedstocks for this purpose. Second, a sustainable production process should also consider valorizing the remaining components. Finally, feedstock availability plays an important role in affecting the process scale, logistics, and feasibility. This work consists of a review on the feedstocks for the sustainable production of BACs in biorefineries, covering the type of BAC, composition, and availability. Some example biorefineries are proposed using wheat straw, hemp and grapevine shoots. As a main conclusion, multiple raw materials have the potential to obtain BACs that can become economic drivers of biorefineries. This is an interesting outlook, as the integral use of the feedstocks may not only allow obtaining different types of BACs, but also other fiber products and energy for the process self-supply.

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“…A similar study was also done by Sornplang et al (2016) to investigate the susceptibility of 93 Lactobacillus strains to seven antimicrobial agents and found that more than 50 % of Lactobacillus species were intrinsically resistant to vancomycin, streptomycin, ciprofloxacin, and sulfamethoxazole-trimethoprim. A study was done by Dubourg et al (2015) to characterize the susceptibility levels of Lactobacillus spp. against antimicrobial agents showed species dependent outcomes.…”

Section: Antibiotic Resistance In Labmentioning

confidence: 99%

Human milk as a potential source for isolation of probiotic lactic acid bacteria: a mini review

Mustakim¹,

Sinawat²,

Salleh³

et al. 2019

Food Res.

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Probiotics are living microorganism that can be employed as a new approach to promote human health. These organisms are found to have attractive means for health due to their probiotic properties particularly in generating antimicrobial activity. Lactobacillus spp. is one of the main genera commonly used for probiotic purpose. Human milk is a potential source of Lactobacillus spp. and one of the criteria that found beneficial is that it is of human origin, which could be more reliable sources to be used in human. Lack of studies on isolation of probiotic bacteria from human milk was reported and some probiotic properties show a variation between strains from different regions and population. Therefore, it is important to carry out the isolation of Lactobacillus spp. from a large number of species in the genera to facilitate the finding of the most competent strain to be incorporated as probiotic agent. Moreover, to ensure suitability and compatibility for human use, the probiotic agent originated from human milk should not be an exception. In addition, certain probiotics show a great correlation with prebiotic existed in human milk to boost their function and may suggest an added value to be a suitable candidate as probiotic. This review provides an overview of studies related to human milk as the promising sources for isolation of probiotic microorganisms.

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Assessment of the in vitro antimicrobial activity of Lactobacillus species for identifying new potential antibiotics

Cited by 25 publications

References 17 publications

Relationship between the probiotic Lactobacillus rhamnosus and Enterococcus faecalis during the biofilm formation

Relationship between the probiotic Lactobacillus rhamnosus and Enterococcus faecalis during the biofilm formation

A Review on the Feedstocks for the Sustainable Production of Bioactive Compounds in Biorefineries

Human milk as a potential source for isolation of probiotic lactic acid bacteria: a mini review

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