Assessment of the Exfoliation of Tumor Cells Into the Body Cavities

Moore, George E.; Sako, Kumao; Kondo, Tatsuhei; Badillo, Jorge; Burke, Eugene

doi:10.1097/00006254-196108000-00044

Cited by 12 publications

(14 citation statements)

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“…MOOR et al (16) verificaram que recurrências peritoniais eram resultantes da disseminação microscópica de células cancerígenas pelo tumor primário que invade a superfície da camada serosa. Ao se compararem os níveis destes marcadores nos tumores com extensão até mucosa e/ou muscular (T1-2) com os que invadem serosa ou tecido adjacente (T3-4), encontraram-se níveis elevados de CEA no lavado peritonial de doentes com câncer de maior extensão (P = 0.035).…”

Section: Discussionunclassified

CA72-4 e CEA no soro e no lavado peritonial de doentes com câncer gástrico

Mandorwski

Lourenço

Forones

2002

Arq. Gastroenterol.

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Section: Discussionunclassified

CA72-4 e CEA no soro e no lavado peritonial de doentes com câncer gástrico

Mandorwski

Lourenço

Forones

2002

Arq. Gastroenterol.

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“…Cancer cells were reported to be recognized in a certain frequency on the cytology of peritoneal lavage in patients with gastric [7] and other intra-abdominal cancers [8]. Nakajima et al [9] reported that cancer cells were found on peritoneal lavage in gas tric cancers infiltrating up to the subserosal layer (4.8% of cases) and in those with cancer cells present on the serosal surface (25.2% of cases).…”

Section: Discussionmentioning

confidence: 99%

Recurrent Gastric Cancer after Absolute Curative Resection

Habu¹,

Sunagawa²,

Takeshita³

et al. 1987

Dig Surg

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Among 428 patients who had undergone absolute curative resection of gastric cancer, 57 died of cancer recurrence. One hundred and seventeen patients who had survived longer than 5 years were used as controls. In the recurrence group, the primary lesion was larger and the lymph node metastasis more common as compared with the surviving controls. Prognostic serosal invasion was positive in 74% of the recurrence group and negative in 85% of the surviving controls. The most frequent mode of recurrence was hematogenous metastasis in negative prognostic serosal invasion (75%) and peritoneal disseminated metastasis in positive prognostic serosal invasion (52%).

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“…Through the designation as Stage IV disease [6,13] and the well-established associated poor prognosis [4,5], patients with IFCCs have traditionally been offered palliative care [7,16]. However, some groups suggest that the prognosis of patients with positive IFCCs can be improved through early identification and treatment.…”

Section: Implications Of Ifccs In Treatmentmentioning

confidence: 99%

“…The identification of IFCCs in gastric cancer patients has been used to predict the risk of peritoneal cancer recurrence and predict overall survival [1][2][3]. Patients with IFCCs have a poorer prognosis compared to those with no IFCCs [4,5].With peritoneal dissemination being the most common pattern of metastasis and recurrence in gastric carcinoma, the identification of IFCCs seems prudent [1]. To this end, the most recent TNM classification has included IFCC detection as part of the staging process, denoting M1 disease [6].…”

Section: Introductionmentioning

confidence: 99%

A systematic review of the accuracy and utility of peritoneal cytology in patients with gastric cancer

et al. 2011

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Background There is lack of uniformity in the utilization of peritoneal cytology in gastric cancer management. The identification of intraperitoneal free cancer cells (IFCCs) is believed to confer poor prognosis. However, while some of these patients are palliated, others may undergo more aggressive therapies. In this review, we aimed to identify and synthesize findings on the use of peritoneal cytology in predicting peritoneal recurrence and overall survival in curative gastric cancer patients. Methods Electronic literature searches were conducted using Medline, EMBASE, and the Cochrane Central Register of Controlled Trials from January 1, 1998 to December 31, 2009. We determined the accuracy, sensitivity, and specificity of peritoneal cytology in predicting peritoneal recurrence based on four techniques-conventional cytology, immunoassay, immunohistochemistry, and reverse transcriptase-polymerase chain reaction. Recurrence rates and overall survival rates for curative patients were determined, based on positivity or negativity for IFCCs. Results Twenty-eight articles were included. All four techniques showed wide variations in accuracy, sensitivity, and specificity in predicting peritoneal recurrence. Recurrence rates for patients positive for IFCCs ranged from 11.1 to 100%, while those negative for IFCCs had recurrence rates of 0-51%. Overall survival was significantly reduced for patients with positive IFCCs. Short follow-up periods and possible duplication of results may limit result interpretation. Conclusion The presence of IFCCs appears to increase the risk of peritoneal recurrence and is associated with worse overall survival in gastric cancer patients. Further incorporation of peritoneal cytology in clinical decisionmaking in gastric cancer depends on the development of a consistently accurate and rapid IFCC detection method.

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Assessment of the Exfoliation of Tumor Cells Into the Body Cavities

Cited by 12 publications

References 0 publications

CA72-4 e CEA no soro e no lavado peritonial de doentes com câncer gástrico

CA72-4 e CEA no soro e no lavado peritonial de doentes com câncer gástrico

Recurrent Gastric Cancer after Absolute Curative Resection

A systematic review of the accuracy and utility of peritoneal cytology in patients with gastric cancer

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