Assessment of the efficacy of a grape seed waste in counteracting the changes induced by aflatoxin B1 contaminated diet on performance, plasma, liver and intestinal tissues of pigs after weaning

Ţăranu, Ionelia; Marin, Daniela Eliza; Palade, Laurentiu Mihai; Chedea, Veronica Sanda; Gras, Mihail Alexandru; Rotar, C. M.

doi:10.1016/j.toxicon.2019.02.020

Cited by 50 publications

(37 citation statements)

References 57 publications

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“…AFB1 and AFM1 down-regulated pro-inflammatory cytokine production in the small intestine of mice and pigs [ 100 , 147 ]. AFB1 also affected sIgA and polymeric immunoglobulin receptor (pIgR) expression, thereby affecting sIgA transport in epithelial cells into mucus layers.…”

Section: Intestinal Dysfunction Induced By Mycotoxinsmentioning

confidence: 99%

“…To protect the gut from mycotoxin assault, several approaches have been undertaken to assess the protective effects of different materials on intestinal dysfunction. Lactoferrin [ 79 ], grape seed [ 147 ], silymarin [ 132 ], yeast cell wall [ 102 ], Lactobacillus plantarum [ 100 ], and mannanoligosaccharides [ 104 ] have alleviated AF-induced intestinal disturbances in human intestinal epithelial cells, pigs, broiler chicks, and mice. Probiotic Bacillus subtilis [ 82 ], curcumin [ 150 ], and selenium-rich yeast [ 107 ] have attenuated OTA-induced disruption of intestinal barrier in Caco-2 cells, ducks, and broiler chickens.…”

Section: Interactive Effects Of Mycotoxins On Intestinal Barriermentioning

confidence: 99%

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The Compromised Intestinal Barrier Induced by Mycotoxins

Gao

Meng

Liu

et al. 2020

Toxins

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Mycotoxins are fungal metabolites that occur in human foods and animal feeds, potentially threatening human and animal health. The intestine is considered as the first barrier against these external contaminants, and it consists of interconnected physical, chemical, immunological, and microbial barriers. In this context, based on in vitro, ex vivo, and in vivo models, we summarize the literature for compromised intestinal barrier issues caused by various mycotoxins, and we reviewed events related to disrupted intestinal integrity (physical barrier), thinned mucus layer (chemical barrier), imbalanced inflammatory factors (immunological barrier), and dysfunctional bacterial homeostasis (microbial barrier). We also provide important information on deoxynivalenol, a leading mycotoxin implicated in intestinal dysfunction, and other adverse intestinal effects induced by other mycotoxins, including aflatoxins and ochratoxin A. In addition, intestinal perturbations caused by mycotoxins may also contribute to the development of mycotoxicosis, including human chronic intestinal inflammatory diseases. Therefore, we provide a clear understanding of compromised intestinal barrier induced by mycotoxins, with a view to potentially develop innovative strategies to prevent and treat mycotoxicosis. In addition, because of increased combinatorial interactions between mycotoxins, we explore the interactive effects of multiple mycotoxins in this review.

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Section: Intestinal Dysfunction Induced By Mycotoxinsmentioning

confidence: 99%

Section: Interactive Effects Of Mycotoxins On Intestinal Barriermentioning

confidence: 99%

The Compromised Intestinal Barrier Induced by Mycotoxins

Gao

Meng

Liu

et al. 2020

Toxins

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“…GSM and DSS+GSM groups were fed the control diet, including 8% dried GSM without interfering with the nutritional requirements of weaning piglets, performance, size, and digestibility. The diets were formulated to meet all nutritional requirements for post-weaning piglets (24) as described by (25). Ingredients and chemical composition of the diets are presented in Tables 1A-C.…”

Section: Animals and Experimental Treatmentsmentioning

confidence: 99%

“…For each experimental group, the diarrhea incidence was calculated with the following formula adapted after (26): (total number of diarrhea-affected piglets/total number of experimental piglets) × 100%. Total polyphenol content was measured and identification of different classes of polyphenols and PUFAs of the diets was carried out by Folin-Ciocalteu reaction, HPLC-DAD-MS, and gas chromatography as described by Taranu et al (25,27). Diet antioxidant activity was measured in terms of hydrogen donating or radical scavenging ability, using the stable radical, DPPH, as described previously (28).…”

Section: Animals and Experimental Treatmentsmentioning

confidence: 99%

Effects of Dietary Grape Seed Meal Bioactive Compounds on the Colonic Microbiota of Weaned Piglets With Dextran Sodium Sulfate-Induced Colitis Used as an Inflammatory Model

et al. 2020

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Microbiota affects host health and plays an important role in dysbiosis. The study examined the effect of diet including grape seed meal (GSM) with its mixture of bioactive compounds on the large intestine microbiota and short-chain fatty acid synthesis in weaned piglets treated with dextran sodium sulfate (DSS) as a model for inflammatory bowel diseases. Twenty-two piglets were included in four experimental groups based on their diet: control, DSS (1 g/kg/b.w.+control diet), GSM (8% grape seed meal inclusion in control diet), and DSS+GSM (1 g/kg/b.w., 8% grape seed meal in control diet). After 30 days, the colon content was isolated and used for microbiota sequencing on an Illumina MiSeq platform. QIIME 1.9.1 pipeline was used to process the raw sequences. Both GSM and DSS alone and in combination affected the diversity indices and Firmicutes:Bacteroidetes ratio, with significantly higher values in the DSS-afflicted piglets for Proteobacteria phylum, Roseburia, Megasphera and CF231 genus, and lower values for Lactobacillus. GSM with high-fiber, polyphenol and polyunsaturated fatty acid (PUFA) content increased the production of butyrate and isobutyrate, stimulated the growth of beneficial genera like Prevotella and Megasphaera, while countering the relative abundance of Roseburia, reducing it to half of the DSS value and contributing to the management of the DSS effects.

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“…Among them, Aflatoxin B 1 (AFB 1 ) has increasingly attracted public attention because of its strongest toxic effect and high carcinogenicity [2][3][4]. Aflatoxin is widely used in food ingredients such as peanuts, milk, cereals [5,6]. It is not easily inactivated during cooking.…”

Section: Introductionmentioning

confidence: 99%

Detection of Aflatoxin B1 Based on a Porous Anodized Aluminum Membrane Combined with Surface-Enhanced Raman Scattering Spectroscopy

Feng

et al. 2020

Nanomaterials

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An Aflatoxin B1 (AFB1) biosensor was fabricated via an Ag nanoparticles assembly on the surface of a porous anodized aluminum (PAA) membrane. First, the Raman reporter 4-Aminothiophenol (4-ATP) and DNA (partially complementary to AFB1 aptamer) were attached to the surface of Ag nanoparticles (AgNPs) by chemical bonding to form a 4-ATP-AgNPs-DNA complex. Similarly, the surface of a PAA membrane was functionalized with an AFB1 aptamer. Then, the PAA surface was functionalized with 4-ATP-AgNPs-DNA through base complementary pairing to form AgNPs-PAA sensor with a strong Raman signal. When AFB1 was added, AgNPs would be detached from the PAA surface because of the specific binding between AFB1 and the aptamer, resulting in a reduction in Raman signals. The detection limit of the proposed biosensor is 0.009 ng/mL in actual walnut and the linear range is 0.01–10 ng/mL. The sensor has good selectivity and repeatability; it can be applied to the rapid qualitative and quantitative detection of AFB1.

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Assessment of the efficacy of a grape seed waste in counteracting the changes induced by aflatoxin B1 contaminated diet on performance, plasma, liver and intestinal tissues of pigs after weaning

Cited by 50 publications

References 57 publications

The Compromised Intestinal Barrier Induced by Mycotoxins

The Compromised Intestinal Barrier Induced by Mycotoxins

Effects of Dietary Grape Seed Meal Bioactive Compounds on the Colonic Microbiota of Weaned Piglets With Dextran Sodium Sulfate-Induced Colitis Used as an Inflammatory Model

Detection of Aflatoxin B1 Based on a Porous Anodized Aluminum Membrane Combined with Surface-Enhanced Raman Scattering Spectroscopy

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