Assessment of the carcinogenicity associated with oral exposures to hydrogen peroxide

Hydrogen peroxide tooth-whitening (bleaching) products: Review of adverse effects and safety issues

“…15,18 Individuals with acatalasia lack catalase activity, leading to high endogenous H 2 O 2 levels causing necrosis and ulceration of soft and hard tissues. 19 Hydrogen peroxide toxicity Thirty per cent H 2 O 2 can cause severe irritation or burns on contact with skin or eyes.…”

The influence of a hydrogen peroxide and glycerol containing mouthrinse on plaque accumulation: a 3‐day non‐brushing model

“…Hydrogen peroxide (H 2 O 2 ) was first isolated in 1818 by reacting barium peroxide with nitric acid (5). Hydrogen peroxide, alone or in combination with salts, has been used in dentistry for over 70 years for instance in the treatment of peri‐coronitis caused by anaerobic microorganisms.…”

“…Peroxide that creates an aerobic atmosphere is destructive to these microorganisms. No hazard is likely to be associated with the long‐term use of H 2 O 2 at concentrations found in oral care products (5).…”

10. Control and management of Harmful Algal Blooms

“…Hydrogen peroxide degrades within hours of addition [221][222][223][224], is not considered to be carcinogenic [225] and is unlikely to impact signiicantly upon aquatic biota at the concentrations required for cyanobacterial removal [177,226,227]. Hydrogen peroxide should not pose a risk to ecosystems or humans if treated eluent is discharged to the environment or for reuse.…”