Assessment of the Association between Genetic Polymorphisms in the &lt;b&gt;&lt;i&gt;CHI3L1&lt;/i&gt;&lt;/b&gt; Gene and Asthma Risk

Huang, Qiu-Pin; Xie, Zheng-Fu; Huang, Jian

doi:10.1159/000522393

Cited by 3 publications

(3 citation statements)

References 31 publications

(48 reference statements)

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“…Cold weather can induce asthma symptoms that are more severe in patients with uncontrolled asthma than in those with well-controlled asthma [13]. Further, more than 100 genes have been shown to cause asthma, such as the BsmI (rs1544410) and ApaI (rs7975232) polymorphisms of the vitamin D receptor gene, the rs20541 and rs1800925 polymorphisms of IL13, and the rs4950928, rs10399931, and rs8883125 polymorphisms of chitinase 3-like 1 [14][15][16].…”

Section: Asthma Inducersmentioning

confidence: 99%

Drug Development from Natural Products Based on the Pathogenic Mechanism of Asthma

Kim,

Bae,

Bok

et al. 2023

IJMS

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Asthma is a chronic inflammatory disease of the pulmonary system associated with many wheeze-to-sleep apnea complications that may lead to death. In 2019, approximately 262 million patients suffered from asthma, and 455 thousand died from the disease worldwide. It is a more severe health problem in children and older adults, and as the aging of society intensifies, the problem will continue to worsen. Asthma inducers can be classified as indoor and outdoor allergens and can cause asthma due to their repeated invasion. There are several theories about asthma occurrence, such as the imbalance between Th1 and Th2, inflammation in the pulmonary system, and the abnormal apoptosis/cell proliferation of cells related to asthma. Although there are many medications for asthma, as it is an incurable disease, the purpose of the drugs is only to suppress the symptoms. The current drugs can be divided into relievers and controllers; however, as they have many adverse effects, such as immune suppression, growth retardation, promotion of cataracts, hyperactivity, and convulsions, developing new asthma drugs is necessary. Although natural products can have adverse effects, the development of asthma drugs from natural products may be beneficial, as some have anti-asthmatic effects such as immune modulation, anti-inflammation, and/or apoptosis modulation.

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Section: Asthma Inducersmentioning

confidence: 99%

Drug Development from Natural Products Based on the Pathogenic Mechanism of Asthma

Kim,

Bae,

Bok

et al. 2023

IJMS

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“…11 Another meta-analysis of 16 publications, comprising 18 studies involving 5005 asthma patients and 9725 controls, demonstrated that the CHI3L1 polymorphisms rs4950928, rs10399931, and rs883125 are vital genetic factors for asthma in East Asian individuals. 12 Using targeted next-generation sequencing (NGS), Liu et al 13 analyzed 211 asthma-related genes selected on the basis of database searches in a cohort of 284 patients with asthma and 205 healthy controls from the Southern Han Chinese population.…”

Section: Introductionmentioning

confidence: 99%

“…A meta‐analysis of 11 studies, involving a total of 2895 patients and 2914 controls, identified the IL13 SNP rs1800925 as a risk factor for allergic asthma in the Asian population 11 . Another meta‐analysis of 16 publications, comprising 18 studies involving 5005 asthma patients and 9725 controls, demonstrated that the CHI3L1 polymorphisms rs4950928, rs10399931, and rs883125 are vital genetic factors for asthma in East Asian individuals 12 . Using targeted next‐generation sequencing (NGS), Liu et al 13 .…”

Section: Introductionmentioning

confidence: 99%

One panel with four single nucleotide polymorphisms for Chinese children with asthma: Integrating public data and whole exome sequencing

Zhou,

Li,

Zhou

et al. 2024

Pediatric Allergy Immunology

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BackgroundPolymorphisms in susceptibility genes are a major risk factor for the development of asthma. Understanding these genetic variants helps elucidate asthma's pathogenesis, predict its onset, expedite antiasthma medication development, and achieve precise targeted individualized treatment. This study developed a test kit based on susceptibility genes for predicting asthma in Chinese children.MethodsThe present study constructed a VariantPro Targeted Library Preparation System with 72 single nucleotide polymorphism (SNP) loci associated with asthma from the ClinVar, OMIM, and SNPedia databases. These SNP loci were detected in the peripheral blood of 499 children with asthma and 500 healthy children. Significant differences were discovered for seven SNP loci. Simultaneously, whole exome sequencing of 46 children with asthma and 50 healthy children identified eight SNP loci with significant differences. The 15 SNP loci identified from Chinese children with asthma were validated in an independent population of 97 children with asthma and 93 healthy children by conducting multiplex polymerase chain reaction (PCR)–next‐generation sequencing genotyping.ResultsFour loci (rs12422149, rs7216389, rs4065275, and rs41453444) were identified, and a single‐tube multifluorescent qPCR (real‐time quantitative PCR) test kit was developed using these four SNP loci. The kit was tested on 269 children with asthma and 724 children with bronchopneumonia.ConclusionsWe identified four loci as susceptibility genes and developed a quantitative PCR test kit for predicting asthma development in Chinese children.

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The emerging role of CHI3L1 as a diagnostic marker and therapeutic target in allergic diseases and respiratory comorbidities

Zeng,

Tao,

Sun

et al. 2024

Allergy Medicine

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Assessment of the Association between Genetic Polymorphisms in the <b><i>CHI3L1</i></b> Gene and Asthma Risk

Cited by 3 publications

References 31 publications

Drug Development from Natural Products Based on the Pathogenic Mechanism of Asthma

Drug Development from Natural Products Based on the Pathogenic Mechanism of Asthma

One panel with four single nucleotide polymorphisms for Chinese children with asthma: Integrating public data and whole exome sequencing

The emerging role of CHI3L1 as a diagnostic marker and therapeutic target in allergic diseases and respiratory comorbidities

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