Assessment of the association between prenatal exposure to multiple ambient pollutants and preterm birth: A prospective cohort study in Jinan, east China

Wang, Lifeng; Fang, Lei; Fang, Zhenya; Zhang, Meihua; Zhang, Lin

doi:10.1016/j.ecoenv.2022.113297

Cited by 8 publications

(9 citation statements)

References 49 publications

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“…The PM2.5-exposed mouse model was established by intratracheal instillation of PM2.5 at 1.5 d, 7.5 d, and 12.5 d of pregnancy ( Figure 2A ). The amount of PM2.5 particulate in the tracheal droplets was calculated based on 2020 PM2.5 exposure of pregnant women in Jinan, Shandong province ( Wang et al, 2022 ), combined with physiological indicators of pregnant mice ( Vermillion et al, 2018 ). Mice were euthanized and dissected on 15.5 d, and the weight of the fetus, the number of fetuses, and the weight of the placenta were assessed.…”

Section: Resultsmentioning

confidence: 99%

“…Our previous epidemiological study identified that prenatal exposure to increased PM2.5 could shorten the gestation period and increased the risk of preterm birth in Jinan, the capital of Shandong Province, China ( Wang et al, 2022 ). Jinan is a large city in northern China, with an area of 7.6×10 3 km 2 and a population of more than 9 million, and its geographical structure is a typical basin texture surrounded by mountains on 3 of its 4 sides, hindering the dispersion of environmental pollutants.…”

Section: Introductionmentioning

confidence: 99%

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PM2.5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9/CYP1A1 transcriptional axis

Li,

Zhang

et al. 2023

eLife

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Epidemiological studies have demonstrated that fine particulate matter (PM2.5) is associated with adverse obstetric and postnatal metabolic health outcomes, but the mechanism remains unclear. This study aimed to investigate the toxicological pathways by which PM2.5 damaged placental trophoblasts in vivo and in vitro. We confirmed that PM2.5 induced adverse gestational outcomes such as increased fetal mortality rates, decreased fetal number and weight, damaged placental structure, and increased apoptosis of trophoblasts. Additionally, PM2.5 induced dysfunction of the trophoblast cell line HTR8/SVneo, including in its proliferation, apoptosis, invasion, migration and angiogenesis. Moreover, we comprehensively analyzed the transcriptional landscape of HTR8/SVneo cells exposed to PM2.5 through RNA-Seq and observed that PM2.5 triggered overexpression of pathways involved in oxidative stress and mitochondrial apoptosis to damage HTR8/SVneo cell biological functions through CYP1A1. Mechanistically, PM2.5 stimulated KLF9, a transcription factor identified as binding to CYP1A1 promoter region, which further modulated the CYP1A1-driven downstream phenotypes. Together, this study demonstrated that the KLF9/CYP1A1 axis played a crucial role in the toxic progression of PM2.5 induced adverse pregnancy outcomes, suggesting adverse effects of environmental pollution on pregnant females and putative targeted therapeutic strategies.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

PM2.5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9/CYP1A1 transcriptional axis

Li,

Zhang

et al. 2023

eLife

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“…In Australia, ShannonMelody reported that maternal exposure to even low levels of NO 2 and PM 2.5 was associated with fetal growth restriction such as small for gestational age and term low birth weight ( 34 ). In our previous study, we also discussed the association between simultaneous various ambient pollutants exposure and preterm birth, and we find that, after adjusting the cofounding effects of demographical variables, NO 2 , CO, and SO 2 , maternal exposure to O 3 increased risk of preterm birth [odds ratio 95% CI: 1.62 (1.19, 2.37), P < 0.05] ( 26 ).…”

Section: Discussionmentioning

confidence: 97%

“…Pregnant women and fetuses are more vulnerable to environmental hazards such as ozone and particulate matter, but knowledge regarding the maternal and fetal effects of prenatal ozone exposure is limited. Previous studies indicate that ozone exposure can be linked to mortality and morbidity across the lifespan, including stillbirth, intrauterine growth restriction, preterm birth, and low birth weight ( 26 , 29 ). Studies conducted among 1,125 pregnant women show that third trimester 8 h maximum ozone exposure is associated with an increased risk of adiposity at 5 months postpartum ( 30 ).…”

Section: Discussionmentioning

confidence: 99%

“…In line with our previous study ( 26 ), the hourly monitored atmospheric ozone in Jinan is acquired from the Air Quality and Pollution Measurement platform, publicly available at https://aqicn.org/ . The data were collected from 2014 to 2021, during which the prenatal ozone exposure level is calculated based on the daily averaged ozone from the first day of pregnancy confirmation to the day of delivery.…”

Section: Methodsmentioning

confidence: 99%

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Association between prenatal exposure to ambient ozone, birth weight, and macrosomia in healthy women

Zheng

Tian²,

Ma³

et al. 2022

Front. Public Health

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Studies have shown that prenatal ozone exposure is associated with an increased risk of adverse pregnancy outcomes, among which abnormal birth weight is a detrimental factor for diseases in adulthood, but the association between birth weight and ozone is inconclusive. Herein, we conducted this study by enrolling 407 couples of pregnant women and collected their demographical materials, their exposure to ambient ozone was assessed according to the place of their residence. The hourly monitored ozone was first averaged to the daily level, then monthly and whole-gestationally levels. After adjusting confounders, we processed a multivariate generalized addictive analysis to predict the association between prenatal ozone exposure and birth weight. We also divided the cohort into two categories according to whether the infant met the standard of macrosomia, and the occurrence of macrosomia was studied via univariate and multivariate logistic regression analyses as extreme conditions of the effects of ozone exposure on birth weight. We found that the ground-level ozone in Jinan changed with temperature periodically, higher in summer and lower in winter. Over the past 8 years from 2014, the ambient ozone increased by 1.74 μg/m3 per year. Of the 407 singleton-pregnant women, 21 infants were diagnosed with macrosomia. After adjusting confounders, we found that each unit increase in prenatal ozone exposure caused 8.80% [ORozone90%CI: 0.912 (0.850, 0.978)] decreased risk of macrosomia, but the splined ambient ozone exposure data was not statistically associated with birth weight, which is probably due to the limited sample size. In conclusion, prenatal ozone exposure is associated with decreased risk of macrosomia but is weakly linked to birth weight.

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Association between traffic-related air pollution and osteoporotic fracture hospitalizations in inland and coastal areas: evidences from the central areas of two cities in Shandong Province, China

Zhang

et al. 2023

Arch Osteoporos

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Assessment of the association between prenatal exposure to multiple ambient pollutants and preterm birth: A prospective cohort study in Jinan, east China

Cited by 8 publications

References 49 publications

PM2.5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9/CYP1A1 transcriptional axis

PM2.5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9/CYP1A1 transcriptional axis

Association between prenatal exposure to ambient ozone, birth weight, and macrosomia in healthy women

Association between traffic-related air pollution and osteoporotic fracture hospitalizations in inland and coastal areas: evidences from the central areas of two cities in Shandong Province, China

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