Association between traffic-related air pollution and osteoporotic fracture hospitalizations in inland and coastal areas: evidences from the central areas of two cities in Shandong Province, China

Purpose of Review The purpose of this review is to provide a background of osteoporosis and air pollution, discussing increasing incidence of the disease with exposure to pollutants and the role that inflammation may play in this process. Recent Findings Osteoporosis-related fractures are one of the most pressing challenges for the ageing global population, with significant increases in mortality known to occur after major osteoporotic fractures in the elderly population. Recent studies have established a firm correlative link between areas of high air pollution and increased risk of osteoporosis, particularly alarming given the increasingly urban global population. While the culprit pollutants and molecular mechanisms underlying this phenomenon have not yet been elucidated, initial studies suggest a role for inflammatory cascades in this phenomenon. Summary While much more research is required to identify the most damaging air pollutants and to delineate the specific inflammatory molecular mechanisms, it is clear from the literature that shedding light on these pathways would unveil potential therapeutic targets to treat bone diseases, including osteoporosis. Major deficiencies of current animal models highlight the need for complex human invitro models such as organ-on-a-chip technology to better understand the impact of air pollution.

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Associations between traffic-related air pollution and allergic rhinitis outpatient visits in three cities of Gansu Province

Ma,

Qu,

Dong

et al. 2024

Environ. Sci.: Processes Impacts

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Association between traffic-related air pollution and osteoporotic fracture hospitalizations in inland and coastal areas: evidences from the central areas of two cities in Shandong Province, China

Cited by 4 publications

References 78 publications

Effects of ambient air pollution on the hospitalization risk and economic burden of mental disorders in Qingdao, China

Effects of ambient air pollution on the hospitalization risk and economic burden of mental disorders in Qingdao, China

Air Pollution and Osteoporosis

Associations between traffic-related air pollution and allergic rhinitis outpatient visits in three cities of Gansu Province

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