Assessment of the Antidiabetic Potential of the Ethanolic Extract of Date Palm (Phoenix Dactylifera) Seed in Alloxan-Induced Diabetic Rats

Food waste valorization practices have gained considerable attention focusing on the conversion of the waste into valuable products. In this context, the present study provides an insight into a new Eudragit RS100 based nanosystem as a carrier of date palm (Phoenix dactylifera L.) seeds oil known for its an antidiabetic activity. A priori systematic study was carried out in order to understand the individual impact of all contributing factors considered by the nanoprecipitation method. Then, date seeds oil nanoparticles were prepared, characterized and analyzed for their in vitro inhibition activity against: α-amylase and α-glucosidase. The results showed that the developed nanoparticles had an average diameter around 207 nm, a ζ-potential of +59 mV, and an encapsulation efficiency equal to 97 ± 1% with a loading capacity of 0.48 mg•mg −1 . The α-amylase and α-glucosidase IC 50 were found to be 87.6 and 155.3 μg•mL −1 , respectively. Therefore, this study may surely open new perspectives for the development of novel health-promoting plant oils loaded-nanocarriers for several purposes.

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Assessment of the Antidiabetic Potential of the Ethanolic Extract of Date Palm (Phoenix Dactylifera) Seed in Alloxan-Induced Diabetic Rats

Abstract: Background: Reports exist of the allopathic use of dates as a hypoglycemic, antioxidant and anti-diabetic agent. Date palm seed have also been found to be of nutritional and medicinal value.

Cited by 5 publications

References 48 publications

Date palm fruit extract ameliorated pancreatic apoptosis, endocrine dysfunction and regulatory inflammatory cytokines in Streptozotocin-induced diabetes in rats

Date palm fruit extract ameliorated pancreatic apoptosis, endocrine dysfunction and regulatory inflammatory cytokines in Streptozotocin-induced diabetes in rats

Saudi date cultivars' seed extracts inhibit developing hepatic steatosis in rats fed a high-fat diet

Poly(ethyl acrylate-co-methyl Methacrylate-co-trimethylammoniethyl methacrylate chloride) (Eudragit RS100) Nanocapsules as Nanovector Carriers for Phoenix dactylifera L. Seeds Oil: a Versatile Antidiabetic Agent

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