Saudi date cultivars' seed extracts inhibit developing hepatic steatosis in rats fed a high-fat diet

Ali Zarie, Arwa; Osman, Magdi A.; Alshammari, Ghedeir M.; Hassan, Amro B.; ElGasim Ahmed Yagoub, Abu; Abdo Yahya, Mohammed

doi:10.1016/j.sjbs.2023.103732

Cited by 2 publications

(2 citation statements)

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“…But, overall, no harmful effects related to the consumption of date seed coffee have been shown [51]. Similar results were obtained in a 28-day study in adult male Wistar albino rats [89]. The rats were fed a high-fat diet ad libitum.…”

Section: Subchronic and Chronic Toxicological Datasupporting

confidence: 76%

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A Comprehensive Review of the Nutritional Composition and Toxicological Profile of Date Seed Coffee (Phoenix dactylifera)

Kiesler,

Franke,

Lachenmeier

2024

Applied Sciences

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Approximately 8 million tons of dates (Phoenix dactylifera) are produced globally each year. The seeds of the fruit, which make up 10–15% of its weight, are typically discarded. Date seed coffee is a sustainable food system innovation rooted in the traditions of high date-producing regions. Dating back to the late 19th century, date seed coffee has evolved from a historical coffee substitute to a modern caffeine-free alternative. Date seed coffee has a long history of consumption in the European Union (EU). This indicates that it may not require novel food authorization. The composition of date seeds is evaluated in this review and a toxicological risk assessment for date seed coffee is conducted. Subchronic studies show that consuming date seed or date seed coffee has no adverse effects. Therefore, currently unavailable chronic toxicity, carcinogenicity, and reproductive toxicity studies may be unnecessary. However, for a comprehensive evaluation, it is recommended to conduct an in vitro mutagenicity test. This review provides information on the safety of date seed coffee and highlights the need for further research.

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Section: Subchronic and Chronic Toxicological Datasupporting

confidence: 76%

“…date seed extract. Similar metabolic effects to the test substance atorvastatin were observed in the animals treated with the date seed extract [89].…”

Section: Subchronic and Chronic Toxicological Datasupporting

confidence: 71%