Assessment of the anti‐feeding and insecticidal effects of the combination of dinotefuran, permethrin and pyriproxyfen (<scp>V</scp>ectra<sup>®</sup><scp>3D</scp>) against<i><scp>T</scp>riatoma infestans</i>on rats

Tahir, Djamel; Davoust, Bernard; Varloud, Marie; Bérenger, Jean-Michel; Raoult, Didier; Alméras, Lionel; Parola, Philippe

doi:10.1111/mve.12206

Cited by 6 publications

(1 citation statement)

References 48 publications

(65 reference statements)

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“…This approach has been registered to provide broad-spectrum activity against nematodes and ectoparasites in dogs [7,18,19]. In addition, the separate use of Vectra ® 3D (dinotefuran-permethrin-pyriproxyfen) and Milbactor ® (milbemycin oxime/praziquantel) have been proven to be effective against a wide range of vectors and Dirofilaria larvae [20][21][22][23][24], leading to a reinforcement of their synergetic effect against Dirofilaria transmission when administrated concomitantly.…”

Section: Discussionmentioning

confidence: 99%

Field Evaluation of Preventive Efficacy of Monthly Multimodal Prophylactic Treatment (Milbactor® and Vectra® 3D) against Dirofilaria spp. in Dogs

et al. 2021

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Dirofilaria immitis and Dirofilaria repens are mosquito-borne pathogens responsible for dirofilariasis in humans and animals. Their transmission and spread depend on the activity of vectors and the frequency of hosts in a given area. Here, we investigated the efficacy of a monthly multimodal prophylactic (MMP) strategy against canine dirofilariasis on Corsica Island (France). The study was conducted as evidence of an efficacy trial in which eighty dogs were divided into two groups: (i) one test group consisted of 25 dogs under the MMP (per-os administration of 1.5 tablets of milbemycin-oxime-praziquantel (Milbactor®) and a topical line-on application of a 3.6 mL solution of dinotefuran-permethrin-pyriproxyfen (Vectra® 3D)) and (ii) a control group under different real-life prophylactic treatments (RLP) based on the use of ectoparasiticides (different formulations: deltamethrin, fluralaner, fipronil) and/or macrocyclic lactone-based products (milbemycin-oxime/praziquantel, milbemycin-oxime, moxidectin) during the period from June to October 2017. All animals were followed up for one year, with blood collected at day 0, with follow-up at 6 and 12 months. Samples were tested for Dirofilaria spp. by species-specific qPCR. At the end of the study, no new case of Dirofilaria spp. infection was detected in the test group. However, the cumulative incidence of Dirofilaria spp. infection was 16.4% (n = 9; p = 0.027) in the control group. The data illustrate that, in contrast to RLP treatment, which failed to protect at least 16.4% of dogs, the MMP based on the simultaneous administration of milbemycin oxime-praziquantel and dinotefuran-permethrin-pyriproxyfen efficiently protects dogs in a high-risk area from Dirofilaria spp. infection.

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Section: Discussionmentioning

confidence: 99%

Field Evaluation of Preventive Efficacy of Monthly Multimodal Prophylactic Treatment (Milbactor® and Vectra® 3D) against Dirofilaria spp. in Dogs

et al. 2021

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Arthropoda

2019

Parasiticide Screening, Volume 1

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Permethrin enhances the agonist activity of dinotefuran on insect cholinergic synaptic transmission and isolated neurons

et al. 2018

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Insect resistance mechanisms against pesticides lead to the development and the search of new pesticide combinations in order to delay the resistance. The combination of neonicotinoids with pyrethroids was currently proposed but the mode of action of these compounds at synaptic and extrasynaptic levels needs to be further explored. In the present study, we evaluated the effect of the combination of two insecticides, permethrin and dinotefuran, on cockroach cholinergic synaptic transmission and on isolated cell bodies. We first found that combination of 5 μM permethrin and dinotefuran enhances depolarization of the sixth abdominal ganglion compared to dinotefuran alone, without an inhibition of the spontaneous activity. However, a pretreatment with 1 μM dinotefuran or permethrin before bath application of the mixture inhibits the ganglionic depolarization. Compared to permethrin, 1 μM dinotefuran induces a persistent enhancement of spontaneous activity. Interestingly, at extrasynaptic level, using dorsal unpaired median neurons and Kenyon cells, we found that combination of both 1 μM dinotefuran and permethrin resulted in an increase of the mixture-induced current amplitudes. Pretreatment with 1 μM dinotefuran strongly decreases the currents whereas permethrin induces a time-dependent inhibition. These data demonstrate that the combination of dinotefuran and permethrin enhances the effect of dinotefuran.

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Assessment of the anti‐feeding and insecticidal effects of the combination of dinotefuran, permethrin and pyriproxyfen (Vectra^®3D) againstTriatoma infestanson rats

Cited by 6 publications

References 48 publications

Field Evaluation of Preventive Efficacy of Monthly Multimodal Prophylactic Treatment (Milbactor® and Vectra® 3D) against Dirofilaria spp. in Dogs

Field Evaluation of Preventive Efficacy of Monthly Multimodal Prophylactic Treatment (Milbactor® and Vectra® 3D) against Dirofilaria spp. in Dogs

Arthropoda

Permethrin enhances the agonist activity of dinotefuran on insect cholinergic synaptic transmission and isolated neurons

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Assessment of the anti‐feeding and insecticidal effects of the combination of dinotefuran, permethrin and pyriproxyfen (Vectra®3D) againstTriatoma infestanson rats

Cited by 6 publications

References 48 publications

Field Evaluation of Preventive Efficacy of Monthly Multimodal Prophylactic Treatment (Milbactor® and Vectra® 3D) against Dirofilaria spp. in Dogs

Field Evaluation of Preventive Efficacy of Monthly Multimodal Prophylactic Treatment (Milbactor® and Vectra® 3D) against Dirofilaria spp. in Dogs

Arthropoda

Permethrin enhances the agonist activity of dinotefuran on insect cholinergic synaptic transmission and isolated neurons

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Assessment of the anti‐feeding and insecticidal effects of the combination of dinotefuran, permethrin and pyriproxyfen (Vectra^®3D) againstTriatoma infestanson rats