“…Thus, the chemical interaction of both solvent/solute must present similar polarity in order to work efficiently, following the rule “polar dissolves polar.” 5,7,8 The persistence of residues on the dentin surface is left by epoxy resin‐based sealers, which have been widely used in root canal obturation due to their satisfactory physico‐chemical and biological properties 13,14 . In addition, bisphenol A diglycidylether, which is non‐polar solute, is used as a constituent of epoxy resin, and it is poorly soluble in ethanol (polar solvent) 6,7,13,15,16 . Therefore, to clean the residues left on the dentin surface after root canal obturation, xylol and formamide, which are non‐polar compounds, have been recommended as an alternative substance; however, they are considered toxic substances 6,7,10,14,17 …”