2022
DOI: 10.3390/biology11071033
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Assessment of Specific Tumoral Markers, Inflammatory Status, and Vitamin D Metabolism before and after the First Chemotherapy Cycle in Patients with Lung Cancer

Abstract: Background: We aimed to investigate the changes of inflammatory status reflected by serum levels of chitotriosidase (CHT) and neopterin, and how specific tumor markers such as neuron-specific enolase (NSE) and squamous cell carcinoma antigen (SCCA), as well as vitamin D metabolism assessed by vitamin D receptor (VDR) and 25-hydroxy vitamin D3 (25OHD3), were modified after the first cycle of chemotherapy in patients with lung cancer. Methods: We performed this first pilot study on twenty patients diagnosed with… Show more

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Cited by 2 publications
(1 citation statement)
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“…Chitotriosidase and neopterin have been previously evaluated together as biomarkers of macrophage activation in infectious diseases such as brucellosis [ 23 ], ankylosing spondylitis [ 24 ], microvascular complications of type I diabetes [ 6 ], and even lung [ 25 ], breast [ 17 ], and prostate [ 17 ] cancer. Chitotriosidase and CHI3L1 (Chitinase-3-like-1 protein) are part of the same family of chitinases [ 26 ].…”
Section: Discussionmentioning
confidence: 99%
“…Chitotriosidase and neopterin have been previously evaluated together as biomarkers of macrophage activation in infectious diseases such as brucellosis [ 23 ], ankylosing spondylitis [ 24 ], microvascular complications of type I diabetes [ 6 ], and even lung [ 25 ], breast [ 17 ], and prostate [ 17 ] cancer. Chitotriosidase and CHI3L1 (Chitinase-3-like-1 protein) are part of the same family of chitinases [ 26 ].…”
Section: Discussionmentioning
confidence: 99%