Assessment of Some Australian Red Wines for Price, Phenolic Content, Antioxidant Activity, and Vintage in Relation to Functional Food Prospects

Yoo, Yung J.; Prenzler, Paul D.; Saliba, Anthony; Ryan, Danielle

doi:10.1111/j.1750-3841.2011.02429.x

Cited by 25 publications

(25 citation statements)

References 47 publications

(55 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In mice with an average bodyweight of 20 g, the concentrations of grape polyphenols used in this study, 5 mg/kg BW of each compound in a 100 μL gavage volume, equates to 4.38 μM resveratrol, 3.3 μM quercetin, and 3.48 μM catechin. These concentrations are found in dietary components rich in grape polyphenols such as red wine (68;69). Therefore, the 5 mg/kg BW combined polyphenols that potentiated the effects of gefitinib and reduced mammary tumor growth in this study and our previous reports (47;48) should be effective at the cellular level at these low concentrations.…”

Section: Discussionmentioning

confidence: 99%

Grape Polyphenols Inhibit Akt/Mammalian Target of Rapamycin Signaling and Potentiate the Effects of Gefitinib in Breast Cancer

Castillo‐Pichardo

Dharmawardhane

2012

Nutrition and Cancer

View full text Add to dashboard Cite

We recently reported that a combination of dietary grape polyphenols resveratrol, quercetin, and catechin (RQC), at low concentrations, was effective at inhibiting metastatic cancer progression. Herein, we investigate the molecular mechanisms of RQC in breast cancer and explore the potential of RQC as a potentiation agent for the epidermal growth factor receptor (EGFR) therapeutic gefitinib. Our in vitro experiments showed RQC induced apoptosis in gefitinib-resistant breast cancer cells via regulation of a myriad of pro-apoptotic proteins. Since the Akt/mammalian target of rapamycin (mTOR) signaling pathway is often elevated during development of anti-EGFR therapy resistance, the effect of RQC on the mTOR upstream effector Akt and the negative regulator AMP kinase (AMPK) was investigated. RQC was found to reduce Akt activity, induce the activation of AMPK and inhibit mTOR signaling in breast cancer cells. Combined RQC and gefitinib decreased gefitinib resistant breast cancer cell viability to a greater extent than RQC or gefitinib alone. Moreover, RQC inhibited Akt and mTOR, and activated AMPK even in the presence of gefitinib. Our in vivo experiments showed combined RQC and gefitinib was more effective than the individual treatments at inhibiting mammary tumor growth and metastasis in nude mice. Therefore, RQC treatment inhibits breast cancer progression and may potentiate anti-EGFR therapy by inhibition of Akt/mTOR signaling.

show abstract

Section: Discussionmentioning

confidence: 99%

Grape Polyphenols Inhibit Akt/Mammalian Target of Rapamycin Signaling and Potentiate the Effects of Gefitinib in Breast Cancer

Castillo‐Pichardo

Dharmawardhane

2012

Nutrition and Cancer

View full text Add to dashboard Cite

show abstract

“…Twenty-three Cabernet Sauvignon wines from the Mudgee region and 32 Shiraz wines from the Hunter Valley region were analyzed for phenolic content and antioxidant activity (Yoo et al, 2011). DPPH antioxidant activity varied considerably, both within and between varieties.…”

Section: Relationship Between Antioxidant Capacity and Acceptance (Prmentioning

confidence: 99%

Effects of Aging on the Antioxidant Capacity of Red Wines

Lissi

Campos

Calderón

et al. 2014

Processing and Impact on Antioxidants in Beverages

View full text Add to dashboard Cite

“…Screening of various parameters in wines and other food products is on rise in recent years because of their possible role in better health, nutritional value, and disease prevention. There are several reports on the quality of commercially produced wines from various countries such as Italy (Cassino et al., 2016; Garaguso & Nardini, 2015), China (Jiang & Zhang, 2012; Li, Wang, Li, Li, & Wang, 2009), Australia (Yoo, Prenzler, Saliba, & Ryan, 2011), Brazil (Gris et al., 2013), Czech Republic (Stratil et al., 2008), Portugal (Stratil et al., 2008), Romania (Hosu, Cristea, & Cimpoiu, 2014), and Spain (Gómez‐Plaza, Olmos, & Bautista‐Ortín, 2016). Screening of the parameters such as total phenols on commercial wine also helps to assess the quality wines and allocate them into different grades and price.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of secondary metabolites, antioxidant activity, and color parameters of Nepali wines

Pandeya

Rayamajhi

Pokhrel

et al. 2018

Food Science & Nutrition

View full text Add to dashboard Cite

We evaluated the quality of wines produced in Nepal in terms of phenolic, flavonoid, anthocyanin and tannin content, antioxidant capacity, and color parameters using spectrophotometric methods. The total phenolic content, total flavonoid content, and total antioxidant activities in Nepali wines ranged from 85.5 to 960.0 (mean = 360.5 ± 268.7) mg/L GAE, 40.9–551.3 (mean = 188.9 ± 161.5) mg/L QE, and 66.6–905.0 (mean = 332.8 ± 296.5) mg/L AAE, respectively. These parameters were significantly higher in red wines compared to white wines. The phenolic and flavonoid content showed strong correlation with each other as well as with antioxidant activities. Additional parameters measured included various color parameters and carbohydrates. The wine color showed strong correlation with phenol, flavonoid, and antioxidant activity, whereas this correlation was not significant with anthocyanin content. Multivariate analysis was carried out to better describe and discriminate the wine samples. Finally, we compared Nepali wines with wines from other countries.

show abstract

Assessment of Some Australian Red Wines for Price, Phenolic Content, Antioxidant Activity, and Vintage in Relation to Functional Food Prospects

Cited by 25 publications

References 47 publications

Grape Polyphenols Inhibit Akt/Mammalian Target of Rapamycin Signaling and Potentiate the Effects of Gefitinib in Breast Cancer

Grape Polyphenols Inhibit Akt/Mammalian Target of Rapamycin Signaling and Potentiate the Effects of Gefitinib in Breast Cancer

Effects of Aging on the Antioxidant Capacity of Red Wines

Evaluation of secondary metabolites, antioxidant activity, and color parameters of Nepali wines

Contact Info

Product

Resources

About