Assessment of sleep problems in children with familial Mediterranean fever

Makay, Balahan; Kiliçaslan, Serdar Kamer; Anık, Ahmet; Bora, Elçin; Bozkaya, Özlem Giray; Çankaya, Tufan; Ünsal, Erbil

doi:10.1111/1756-185x.12339

Cited by 13 publications

(30 citation statements)

References 39 publications

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“…Patients with a higher number of attacks were noted to experience difficulty in falling asleep, more night wakings and sleep-disordered breathing. 9 In our study, mean total PSQI score of FMF patients was 5.74 AE 3.08 and 41.13% of patients had poor sleep quality. These results are comparable to reported incidence of sleep disorder in other rheumatologic conditions.…”

Section: Discussionmentioning

confidence: 45%

“…showed that sleep quality of pediatric FMF patients was negatively affected by the number of attacks. Patients with a higher number of attacks were noted to experience difficulty in falling asleep, more night wakings and sleep‐disordered breathing …”

Section: Discussionmentioning

confidence: 99%

“…The negative impact of recurrent and chronic pain on everyday functioning of pediatric patients have been demonstrated. 17 Makay et al 9 showed that sleep quality of pediatric FMF patients was negatively affected by the number of attacks. Patients with a higher number of attacks were noted to experience difficulty in falling asleep, more night wakings and sleep-disordered breathing.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of sleep and mood disorders in patients with FMF has been previously investigated. Makay et al . described a higher incidence of anxiety and depression in pediatric FMF patients than their healthy counterparts.…”

Section: Introductionmentioning

confidence: 99%

“…The prevalence of sleep and mood disorders in patients with FMF has been previously investigated. Makay et al 9 described a higher incidence of anxiety and depression in pediatric FMF patients than their healthy counterparts. A similar report by Deger et al 10 found that FMF patients were more likely to be depressed than healthy peers and defined disease to be a significant factor affecting health-related QoL.…”

Section: Introductionmentioning

confidence: 99%

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Incidence of sleep disturbances in patients with familial Mediterranean fever and the relation of sleep quality with disease activity

et al. 2017

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Section: Discussionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Incidence of sleep disturbances in patients with familial Mediterranean fever and the relation of sleep quality with disease activity

et al. 2017

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Decreased serum vitamin B12 and vitamin D levels affect sleep quality in children with familial Mediterranean fever

et al. 2017

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Familial Mediterranean fever is an autoinflammatory disorder characterized by recurrent fever and serositis. We aimed to describe serum vitamin B and vitamin D levels and their correlation with self-reported sleep quality of pediatric FMF patients. Sixty-three children with FMF were enrolled to the study. Information on sleep quality was obtained using self-administration of Pittsburg Sleep Quality Index (PSQI). The patients were divided into subgroups depending on vitamin D serum concentrations: ≥ 20 and < 20 ng/ml. We also grouped patients according to their serum B concentration: ≥ 200, < 200 pg/ml. B levels were not correlated with PSQI scores, whereas significant correlation was found between vitamin D and total PSQI scores and daytime sleepiness. Total PSQI score, sleep disorders and daytime sleepiness sub-scores were statistically high in patients with serum D vitamin levels below 20 ng/ml. Sleep efficiency was found lower in patients with serum B levels below 200 pg/ml. B may have a positive role on effective sleep. More importantly, we suggest that vitamin D is protective against sleep disorders and poor sleep, it may also improve daytime activities.

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The assessment of fatigue and sleep quality among children and adolescents with familial Mediterranean fever: A case-control and correlation study

İncesu,

Kayaalp,

Demirkan

et al. 2024

Eur J Pediatr

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To evaluate the sleep quality and fatigue levels in children with familial Mediterranean fever (FMF) in comparison to healthy children. The Pediatric Quality of Life Multidimensional Fatigue Scale (PedsQL-MFS) and the Pittsburgh Sleep Quality Index (PSQI) were the instruments utilized to assess fatigue and sleep quality in children with FMF and controls, respectively. Spearman’s rank coefficient was decisive in determining the association between patient-reported outcome measures and disease-related features. Two hundred twenty-five (59.3% female) patients and 182 (51.6% female) healthy counterparts were enrolled in the study. In PSQI, where high scores indicate sleep disturbance, the median score was significantly higher in the patient group (5; 3–6) than the control group (3; 2–4) (p < 0.001). PEDsQL-MFS demonstrated significantly lower fatigue levels in the control group than patients (p = 0.01). The level of fatigue in the patient group was found to increase in correlation with sleep problems (r: − 0.750, p < 0.001). Additionally, a high correlation was present between the PSQI/PedsQL-MFS scores and the number of attacks in the last year (r: − 0.645, p < 0.001/r: 0.721, p < 0.001, respectively). There was no difference in terms of fatigue and sleep disorders between mutations (homozygous, heterozygous, or compound heterozygous) in the MEFV gene (p > 0.05). Conclusion: High disease activity has a significant negative impact on the sleep quality and fatigue levels of patients with FMF. This study emphasizes the importance of assessing fatigue and sleep quality with objective outcome tools periodically in FMF patients throughout the disease course. What is Known:• Fatigue is a common matter that often accompanies rheumatic diseases and causes disability.• Chronic rheumatic diseases often experience poor sleep quality. What is New:• In high correlation with the disease severity of familial Mediterranean fever, sleep quality decreases and fatigue level increases significantly.• In familial Mediterranean fever patients, a negative correlation is present between age and the general fatigue and sleep/rest related fatigue scores (low scores indicating greater fatigue) and sleep quality is poorer in the adolescent age group.

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Assessment of sleep problems in children with familial Mediterranean fever

Cited by 13 publications

References 39 publications

Incidence of sleep disturbances in patients with familial Mediterranean fever and the relation of sleep quality with disease activity

Incidence of sleep disturbances in patients with familial Mediterranean fever and the relation of sleep quality with disease activity

Decreased serum vitamin B12 and vitamin D levels affect sleep quality in children with familial Mediterranean fever

The assessment of fatigue and sleep quality among children and adolescents with familial Mediterranean fever: A case-control and correlation study

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