Assessment of Serum Vitamin D and Irisin Levels in Obese Patients

Gouda, Weaam; Mageed, Lamiaa; Shaker, Yehia; Hamimy, Waleed; Afify, Mie

doi:10.7754/clin.lab.2018.180416

Cited by 7 publications

(6 citation statements)

References 1 publication

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“…Irisin levels are indicated significantly correlated negatively with HbA1c, years of diabetes, and positively associated with better glycemic control and bone health in TD1M children ( Kurdiova et al, 2014 ; Faienza et al, 2018 ; Gouda et al, 2018 ). Furthermore, persistent subcutaneous perfusion of irisin improves insulin sensitivity, reduces fasting glycemia by inhibiting gluconeogenesis via phosphoinositide 3-kinase (PI3K)/serine/threonine kinase (Akt)/forkhead box transcription factor O1 (FOXO1) mediated phosphoenolpyruvate carboxykinase (PEPCK) ( Liu et al, 2015 ).…”

Section: Role Of Exercise In Regulating Chronic Diseasesmentioning

confidence: 95%

“…Studies of diabetic mellitus rats demonstrate that running exercise increases the irisin level, glycemic control, bone mass and muscle strength, probable due to the activation of the Wnt/β-catenin signaling pathway and decreased systemic inflammatory process (Andrade et al, 2018;Yang et al, 2018;Sadeghipour et al, 2020). Irisin levels are indicated significantly correlated negatively with HbA1c, years of diabetes, and positively associated with better glycemic control and bone health in TD1M children (Kurdiova et al, 2014;Faienza et al, 2018;Gouda et al, 2018). Furthermore, persistent subcutaneous perfusion of irisin improves insulin sensitivity, reduces fasting glycemia by inhibiting gluconeogenesis via phosphoinositide 3-kinase (PI3K)/serine/threonine kinase (Akt)/forkhead box transcription factor O1 (FOXO1) mediated phosphoenolpyruvate carboxykinase (PEPCK) (Liu et al, 2015).…”

Section: Diabetes Mellitusmentioning

confidence: 98%

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The Role of Irisin in Exercise-Mediated Bone Health

Liu

Guo

Chen

et al. 2021

Front. Cell Dev. Biol.

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Exercise training promotes physical and bone health, and is the first choice of non-drug strategies that help to improve the prognosis and complications of many chronic diseases. Irisin is a newly discovered peptide hormone that modulates energy metabolism and skeletal muscle mass. Here, we discuss the role of irisin in bone metabolism via exercise-induced mechanical forces regulation. In addition, the role of irisin in pathological bone loss and other chronic diseases is also reviewed. Notably, irisin appears to be a key determinant of bone mineral status and thus may serve as a novel biomarker for bone metabolism. Interestingly, the secretion of irisin appears to be mediated by different forms of exercise and pathological conditions such as diabetes, obesity, and inflammation. Understanding the mechanism by which irisin is regulated and how it regulates skeletal metabolism via osteoclast and osteoblast activities will be an important step toward applying new knowledge of irisin to the treatment and prevention of bone diseases such as osteolysis and other chronic disorders.

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Section: Role Of Exercise In Regulating Chronic Diseasesmentioning

confidence: 95%

Section: Diabetes Mellitusmentioning

confidence: 98%

The Role of Irisin in Exercise-Mediated Bone Health

Liu

Guo

Chen

et al. 2021

Front. Cell Dev. Biol.

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“…Studies investigating serum irisin in obese individuals are equivocal. A study including 300 obese participants found that their serum irisin levels were not significantly higher than those in age-and sex-matched controls [9]. Other studies reported lower serum irisin levels in obese than in normal-weight participants, but that the difference was associated with the presence or absence of diabetes mellitus [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Serum Irisin, Adropin, and Preptin in Obese Patients 6 Months After Bariatric Surgery

Glück

Wiewióra

et al. 2019

OBES SURG

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Background/Objectives The reduction of body mass after bariatric surgery affects energy metabolism and may involve changes in irisin, preptin, and adropin production. Subjects and Methods Fifty-five morbidly obese patients with a mean body mass index (BMI) of 45.7 ± 5.8 kg/m 2 were treated with either laparoscopic sleeve gastrectomy(n = 30) or laparoscopic adjustable gastric banding (n = 25). Forty-six (83.6%) were followed-up 6 months after surgery. The control group included 15 healthy non-obese participants. Anthropometric measurements, lipid profiles, HbA1c, and serum irisin, preptin, and adropin were assessed at baseline and on follow-up. Results The serum concentrations of all three peptides were higher at 6 months than at baseline but only irisin (p = 0.02) and adropin (p = 0.000001) were significantly higher. The increase in preptin was borderline significant (p = 0.051). Changes of serum concentrations of all three peptides were bidirectional. Conclusion Body mass reduction resulting from bariatric procedures may change the production of energy regulating peptides, but not always in a favorable manner.

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“…There are some studies investigated that serum irisin is unclear in obese individuals. One previous study includes (300) obese cooperators discovered that serum irisin levels were not significant higher than those in the group of controls (24). Other investigations reported to lowering the serum irisin concentrations in obese subjects than in normal weight, but the variation was correlated with presence or absence of DM (25,26) .…”

Section: Discussionmentioning

confidence: 92%

The Association of Serum Irisin with Vitamin D and Body Mass Index in Healthy Adults

Anwar A. Saiel,

, Rashied M. Rashied2,

Khalid F. AL-Rawi

2021

MLU

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Objectives: This study was designed to explore the relationship between serum irisin hormone with Vitamin D levels and investigate the association of serum Vitamin D3 concentrations and serum irisin levels with BMI of male healthy individuals in Anbar province. Method: This study included 84 Iraqi men with the age range (20-40) year, divided into three groups depending on body mass index (BMI). The weight and height of all participants were taken to extract BMI. The ELISA method has been used to estimate levels of vitamin D and the irisin hormone in the serum. Pearson correlation coefficient was used to find the association between the studied variables. Results: The mean and standard deviation of serum vitamin D concentrations was significantly lower in all groups. This study showed there was non-significant difference in the mean of irisin among the three groups. A negative linear correlation was found between vitamin D and BMI, while a positive correlation with irisin. A positive correlation was found between irisin with BMI. Conclusion: People with a high BMI are deficient in Vitamin D. There was a positively relation between serum irisin levels and BMI.

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Assessment of Serum Vitamin D and Irisin Levels in Obese Patients

Cited by 7 publications

References 1 publication

The Role of Irisin in Exercise-Mediated Bone Health

The Role of Irisin in Exercise-Mediated Bone Health

Serum Irisin, Adropin, and Preptin in Obese Patients 6 Months After Bariatric Surgery

The Association of Serum Irisin with Vitamin D and Body Mass Index in Healthy Adults

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