Serum Irisin, Adropin, and Preptin in Obese Patients 6 Months After Bariatric Surgery

Abstract

Background/Objectives The reduction of body mass after bariatric surgery affects energy metabolism and may involve changes in irisin, preptin, and adropin production. Subjects and Methods Fifty-five morbidly obese patients with a mean body mass index (BMI) of 45.7 ± 5.8 kg/m 2 were treated with either laparoscopic sleeve gastrectomy(n = 30) or laparoscopic adjustable gastric banding (n = 25). Forty-six (83.6%) were followed-up 6 months after surgery. The control group included 15 healthy non-obese participants. Anthropometric measurements, lipid profiles, HbA1c, and serum irisin, preptin, and adropin were assessed at baseline and on follow-up. Results The serum concentrations of all three peptides were higher at 6 months than at baseline but only irisin (p = 0.02) and adropin (p = 0.000001) were significantly higher. The increase in preptin was borderline significant (p = 0.051). Changes of serum concentrations of all three peptides were bidirectional. Conclusion Body mass reduction resulting from bariatric procedures may change the production of energy regulating peptides, but not always in a favorable manner.

Association of circulating preptin with non-alcoholic fatty liver disease: A case-control study

“…In previous studies, an association between serum preptin and BMI has been reported [19,23,24]. Nevertheless, we did not determine a correlation between preptin and BMI.…”

Adropin as a potential mediator of the metabolic system‐autonomic nervous system‐chronobiology axis: Implementing a personalized signature‐based platform for chronotherapy

“…The effect of weight loss on plasma adropin concentrations was dependent on baseline adropin levels, with a negative correlation between baseline and a decline in concentrations after weight loss 26 . Following bariatric surgery, serum adropin levels increased as part of the change in energy production 27 . Increased serum adropin levels in patients with cardiac cachexia correlated positively with brain natriuretic peptide (BNP) levels and New York Heart Association (NYHA) class and negatively with BMI and serum albumin levels 28 …”

“…26 Following bariatric surgery, serum adropin levels increased as part of the change in energy production. 27 Increased serum adropin levels in patients with cardiac cachexia correlated positively with brain natriuretic peptide (BNP) levels and New York Heart Association (NYHA) class and negatively with BMI and serum albumin levels. 28 Overall, these data support a regulatory role for adropin in the metabolic pathways of glucose and fatty acids and their complications.…”

Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions

“…On the other hand, it has been seen that in mice, the overexpression of adropin reduces weight gain, attenuates hepatosteatosis, increases fatty acid oxidation throughout the body, improves insulin sensitivity, and improves glucose tolerance [ 67 ]. A study of patients who underwent bariatric surgery showed that weight loss increased levels of adropin [ 80 ]. Still, in this respect, there is increasing evidence that adropin is a biomarker of cardiovascular dysfunction, initially because in vitro tests showed that endothelial cells treated with adropin had greater proliferation, migration, formation of a capillary-like tube, and positive regulation of the expression of nitric oxide endothelial synthase (eNOS).…”