Assessment of selected medicinal plants indigenous to West Africa for antiprotozoal activity

Bello, Oluwasesan M.; Zaki, Ahmed A.; Khan, Shabana I.; Fasinu, Pius S.; Ali, Zulfiqar; Khan, Ikhlas A.; Usman, L. A.; Oguntoye, O.S.

doi:10.1016/j.sajb.2017.08.002

Cited by 26 publications

(23 citation statements)

References 94 publications

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“…It is used as purgative against paralysis, gonorrheal sores, leprosy, biharzia, furuncles, infantile hyperpnexia and ulcers ( Bello et al., 2017 , 2019 ; Sofowora, 1982 ; Ushie et al., 2013 ). In West Indies, decoction from B. verticillata which is usually called Alpha Marrow or Wild Margaret, it is employed to manage high blood pressure and as an abortifacient ( Baldé et al., 2015 ) (see Figure 1 ).…”

Section: Scientific Classification and Kingdommentioning

confidence: 99%

A review on Borreria verticillata: A potential bionematicide, channeling its significant antimicrobial activity against root-knot nematodes

Izuogu

Bello

Bello³

2020

Heliyon

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Phytopesticides are human-friendly beside been easily accessible and bio-degradable, are therefore environmentally friendly compared to the synthetic pesticides which huge adverse effects on human, animals and the ecosystem. Plants are large reservoir of secondary metabolites largely untapped or under-tapped for use as pesticides. One problem associated with this is to identify plants which can be assessed and further exploited for this use. Borreria verticillata belongs to Rubiaceae , it is native to South Americas but gained popularity globally. It is known as a weed, showing resistance to many synthetic pesticides and can be grown on a wide range of soil types. B. verticillata is used traditionally against skin diseases such as eczema, infectious dermatitis and scabies . Its antimicrobial application is large and efficient as revealed by most authors. This article inclines to propose and offer current studies with information on the various application of this plant species against various microorganisms, thereby extending its use against plant parasitic nematodes which cause severe yield losses to numerous agricultural crops. Most search engines, journals and dissertation search engines i.e. Google scholar, pubmed, sciencedirect, scopus, web of science, springer, elsevier, like Open-thesis, OATD, ProQuest and EthOs were queried by employing titles such as B. verticillata , Borreria verticillata and biological activity of B. verticillata . The most synonymous name was queried too i.e. Spermacoce verticillata . This review suggests a main point about this resistant weed i.e. its significant antimicrobial activity. It further emphases the need exploits this useful effect against nematodes since they are microorganisms. Phytochemistry of the B. verticillata was gathered in this study and the compounds isolated from the plant i.e. terpenes, iridoids, flavonoids and alkaloids (29 compounds) further provide a basis for a significant antihelmintic effect. The review concludes on the need to extends its antimicrobial activity to sustainable agriculture. Since it is a very common plant in Nigeria, it is easily accessible to farmer protect their cultivations from plant-parasitic nematode attacks.

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Section: Scientific Classification and Kingdommentioning

confidence: 99%

A review on Borreria verticillata: A potential bionematicide, channeling its significant antimicrobial activity against root-knot nematodes

Izuogu

Bello

Bello³

2020

Heliyon

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“…The methanolic extract of L. taraxacifolia leaves administered to different groups of Swiss mice at 200 mg/kg per body weight significantly ( p < 0.05) inhibited parasitemia and improved survival time as well as some haematological parameters in P. berghei -infected mice. Bello et al [ 34 ], in an in vitro study, also showed that the chloroform extract of Launaea taraxacifolia produced 52% growth inhibition to P. falciparum yielding an IC 50 value of 21.55 μ g/mL.…”

Section: Resultsmentioning

confidence: 99%

The Ethnopharmacological and Nutraceutical Relevance of Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey

Adinortey

Sarfo

Kwarteng

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey is a herb found mostly in tropical Africa. The plant, commonly found in West Africa, is used in the management of many diseases including cardiovascular, respiratory, haematological, endocrine, and metabolic diseases in Ghana, Nigeria, Benin, Serra Leone, and Senegal. This piece provides comprehensive and updated information on the traditional uses, phytochemical constituents, and pharmacological and toxicological information available on Launaea taraxacifolia to support its medicinal uses and also unearth knowledge gaps for future studies. An electronic literature search using search engines, namely, Google Scholar, ScienceDirect, and PubMed, was carried out to obtain information on the plant. Both common and scientific names of the plant were used as keywords for the search process. This paper captured information on Launaea taraxacifolia from 1985 to 2018. The search revealed that the leaves of the plant possess nutritional/pharmacological effects on diseases such as diabetes mellitus, hypertension, cancer, malaria, bacterial infections, and arthritis. The leaf has been shown to be a rich source of phytoconstituents such as flavonoids, phenolic acids, tannins, alkaloids, glycosides, coumarins, triterpenoids, ascorbic acid, lycopene, and β-carotene. Also, isolated phytoconstituents as well as the safety profile of the plant have been documented. This review on Launaea taraxacifolia has provided a one-stop documentation of information in support of the several purported ethnopharmacological uses of the plant. It also reveals information gaps such as the need to research into its pharmacokinetics, interactions with drugs of importance, and its development into a plant-based drug in order to expand its clinical use.

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“…The plant is used as an aphrodisiac, and in the treatment of jaundice, snake bites and skin ailments. C. sesamoides leaf infusions are used to facilitate delivery in both humans and animals (Bedigian, 2003, Bedigian and Adetula, 2004, Grubben and Denton, 2004, Bello et al, 2017. In northern Nigeria, C. sesamoides seeds are used to relieve circumcision pains.…”

Section: Introductionmentioning

confidence: 99%

“…Beside their nutritional benefits, leafy and non-cultivated vegetables (Fig. 4) have been known to possess therapeutic uses (Bello et al, 2017;Bello et al, 2017;Oguntoye et al, 2018). However, many of these cheap but diseases preventing plant species are yet to be sufficiently studied and exploited.…”

Section: Introductionmentioning

confidence: 99%

“…Hence, this study aims at: investigate the phytochemical screening of these noncultivated vegetables' leaves extract; experimentally carry out characterization and application of these medicinal plants species silver nanoparticles (AgNPs) as anti-inflammatory, antioxidant agents and acetylcholinesterase inhibitors. Asada et al, 1985;Rozhon et al, 2018;Aniya et al, 2005;Musa et al, 2011;Tomimori et al, 2012;Adedayo et al, 2015 Obi et al, 2006;Toyin et al, 2012;Benoit-Vical et al, 2008;Konan et al,2014;olander et al, 2014;Nadembega et al, 2011;Diarra et al, 2015;Abubakar et al, 2007 Amujoyegbe et al, 2015;Owoeye et al, 2017;Obi et al, 2006;Thomford et al, 2016;Adetutu et al, 2016;Bello et al, 2017; Bamishaiye et al, 2011;Jimoh et al, 2010;Adeniyi et al, 2012;Aloke et al, 2010;Anosike et al, 2014;Bello et al, 2018c;Cowan, 1999;Anigo et al, 2012;Enechi et al, 2013 u n c o r r e c t e d p r o o f…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Phytobiological Facilitated Production of Silver Nanoparticles from Selected Non-Cultivated Vegetables in Nigeria and Their Biological Potential

Micheal¹,

O.²,

A.³

et al. 2019

tjps

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Plant-mediated synthesis (Silver (Ag) to form nanoparticles) is progressively becoming well accepted in many scientific and pharmaceutical fields. This study is aimed at synthesizing Ag nanoparticles using air-dried leaves of four (4) neglected vegetables i.e. Cerathoteca sesamoides, Ceiba pentandra, Crassocephalum crepidioides, Launaea taraxacifolia. Ultravioletvisible spectroscopy, Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM) were used for characterization. Cell Stabilization Membrane (CSM) and lipoxidase assays, DPPH and ABTS+ assays were used to assess the anti-inflammatory and antioxidant activities of these AgNPs. L. taraxacifolia Ag nanoparticles (LT-AgNPs), C. sesamoides Ag nanoparticles (CS-AgNPs), C. pendandra Ag nanoparticles (CP-AgNPs) and C. crepidioides Ag nanoparticles (CC-AgNPs), were noticed through visual color change. The UV-Vis spectra of the synthesized nanoparticles displayed absorption bands at around 360-440 nm, which is a characteristic band for Ag nanoparticles. The SEM image of the AgNPs formed displayed were spherical in morphology. CC-AgNPs exhibited the most significant inhibitory activity against HRBC (IC50: 32.2) while CS-AgNPs displayed the most significant inhibitory activity against lipoxygenases (IC50: 32.8). CP-AgNPs exhibited the most significant antioxidant effect against both ABTS and DPPH (IC50: 5.5 and 6.4) when compared to ascorbic acid (IC50: 4.7 µg/mL).

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Assessment of selected medicinal plants indigenous to West Africa for antiprotozoal activity

Cited by 26 publications

References 94 publications

A review on Borreria verticillata: A potential bionematicide, channeling its significant antimicrobial activity against root-knot nematodes

A review on Borreria verticillata: A potential bionematicide, channeling its significant antimicrobial activity against root-knot nematodes

The Ethnopharmacological and Nutraceutical Relevance of Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey

Phytobiological Facilitated Production of Silver Nanoparticles from Selected Non-Cultivated Vegetables in Nigeria and Their Biological Potential

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