Assessment of SARS-CoV-2 RNA shedding in semen of 36 males with symptomatic, asymptomatic, and convalescent infection during the first and second wave of COVID-19 pandemic in Italy

Giammanco, GiovanniM; Pavone, Carlo; Cascino, AndreaPio; Baiamonte, Davide; Mirko, Pinelli; Cangelosi, Enrico; Filizzolo, Chiara; Sciortino, Giuseppa; Grazia, SimonaDe; Bonura, Floriana

doi:10.4103/aja2021103

Cited by 9 publications

(2 citation statements)

References 30 publications

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“…Several studies have documented the shedding of SARS-CoV-2 in the semen of men with symptomatic and asymptomatic phases [47,48]. In contrast, other investigators were unable to detect virus particles in the semen of men infected with SARS-CoV-2 [49][50][51]. Hence, the detection of viruses in semen samples remains debatable.…”

Section: Discussionmentioning

confidence: 99%

A Scientometric Evaluation of COVID-19 and Male Reproductive Research

Panner Selvam,

Kapoor,

Baskaran

et al. 2023

Clinics and Practice

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The COVID-19 pandemic due to the SARS-CoV-2 coronavirus showed acute and prolonged effects on human health. In addition, over the past four years, there has been a tremendous surge in COVID-19-related scientific publications, as shown by bibliometric and scientometric studies. However, such analysis of the scientific literature is lacking in the area of male reproduction. The current scientometric study analyzes publication characteristics of articles related to male reproduction and COVID-19 infection. We used the Scopus database to analyze scientometric data (the number of publications, journals, countries, type of documents, and subject area) related to COVID-19 and male reproductive research. Our literature search identified 345 articles related to COVID-19 and male reproductive research. Most of the articles were published in the USA (n = 72), Italy (n = 55), and China (n = 51). Such research was mainly focused around medicine (57.1%), followed by biochemistry, genetics, and molecular biology (25.7%). Also, in the area of male reproduction, only 37.1% (n = 128) of the articles contributed towards original research, whereas 52.8% (n = 182) were review articles and editorials focusing more on sexual dysfunction than infertility. Such a small number of studies published on COVID-19-related effects on male reproduction warrants a significant increase in research, which is required to decipher the mechanism(s) underlying SARS-CoV-2 infection-associated impairment of male reproductive function.

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Section: Discussionmentioning

confidence: 99%

A Scientometric Evaluation of COVID-19 and Male Reproductive Research

Panner Selvam,

Kapoor,

Baskaran

et al. 2023

Clinics and Practice

View full text Add to dashboard Cite

show abstract

“…Angiotensin-converting enzyme 2 (ACE2)-the receptor that has a role in SARS-CoV-2 invasion-is highly expressed in the genitourinary tract and the testes [4,5]. Studies have reported that SARS-CoV-2 is not present in the semen of individuals recovering from COVID-19 [6] or patients with a mild form of COVID-19 in their acute stage of the disease [7]; furthermore, some other results implied that the detection of viral RNA of SARS-CoV-2 is actually rare in semen, yet its RNA could be found in semen even in a small sample size [5,8].…”

Section: Introductionmentioning

confidence: 99%

COVID-19 and Semen Fluid Parameters, a Retrospective Study from Infertility Clinics

Al‐Alami

Albeitawi

ALNatsheh

et al. 2022

Life

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The study of the effects of SARS-CoV-2 infection and/or vaccination on semen fluid analysis (SFA) parameters is still incomplete. The aim of this study is to assess the effect of COVID-19 infection and vaccination on sperm parameters for a sample of individuals visiting multi-infertility clinics in Jordan. SFA records were collected retrospectively between September and November 2021 and analyzed using Jamovi software (version 2.2.5 for Windows); p-values < 0.05 were considered statistically significant. Sperm concentration, progressive motility, normal morphology, and semen liquefaction time, volume, and viscosity were compared among two data categories. In the first category of data, SFA records from 354 participants were separated into four groups: only vaccinated, infected and vaccinated, neither infected nor vaccinated, and only infected. In the other category, SFA from 49 subjects before their infection and/or vaccination and after were classified into the same mentioned groups and analyzed. There were no statistically significant differences between the studied parameters in the SFA records in the first data category and the second. Nevertheless, the sperm concentration was higher among vaccinated subjects compared to unvaccinated ones (p = 0.04). It is concluded that SARS-CoV-2 infection and vaccines have no negative effects on SFA parameters.

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COVID-19: the possibility, ways, mechanisms, and interruptions of mother-to-child transmission

Wang

Dong

2022

Arch Gynecol Obstet

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Background In December 2019, novel coronavirus pneumonia was detected in Wuhan, Hubei Province, China, and as the epidemic spread, such cases emerged worldwide. Recently, the World Health Organization (WHO) named a new mutant Omicron (B.1.1.529), which disrupts the binding of most antibodies to the S protein and has a greater ability to break through the vaccine, posing a serious risk to population safety. Positive pregnant women give birth to positive newborns despite appropriate isolation measures taken by medical staff, suggesting that we may have vertical transmission of the novel coronavirus. This article analyzes and studies the possible vertical transmission path of the new coronavirus in the perinatal period of pregnant women and the antibody-dependent enhancement (ADE), and puts forward effective preventive measures for positive pregnant women to provide further reference for clinical work. Methods We searched multiple databases, including PubMed, CNKI, Google Scholar, WHO COVID-19 database, and CDC database. Search terms included COVID-19, SARS-CoV-2, vertical transmission, Omicron, Vaginal, Breast Feeding, Vaccine, Neonatal, Severe acute respiratory syndrome coronavirus, Pregnancy, and Semen. Selection criteria The following criteria were also met: (1) positive maternal novel coronavirus nucleic acid test; (2) reporting of neonatal outcome; (3) language in Chinese or English; (4) study date or location indicated; (5) no suspected or confirmed duplicated reports. Results There is evidence of vertical transmission, and the risk of possible vertical transmission is 5.7% (75/1314). The article listed four possible vertical transmission routes, namely placental transmission, vaginal upstream transmission, breastfeeding transmission and monocyte, and macrophage transmission route, with placental transmission being the most probable. Meanwhile, SARS-CoV-2 may also enter the placenta to infect the fetus through antibody-dependent enhanced substitution mechanism. We recommend three methods for early surveillance of vertical transmission, namely nucleic acid testing, antibody screening, and antigen testing, and analyze their advantages and disadvantages. Finally, the article provides recommendations in four areas: labor management, neonatal management, nosocomial infection prevention and control, and vaccination. As well as suggesting effective preventive measures for positive pregnant women and analyzing the advantages and disadvantages of vaccination, it is recommended that pregnant women should be vaccinated promptly, but considering that the vaccine may cause fever, it is recommended to consider vaccination cautiously in the first trimester of pregnancy. Conclusion The article concludes that vertical transmission is possible, with placental transmission being the most likely, and that the risk of possible vertical transmission is 5.7% (75/1314). Good personal protection, patien...

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Assessment of SARS-CoV-2 RNA shedding in semen of 36 males with symptomatic, asymptomatic, and convalescent infection during the first and second wave of COVID-19 pandemic in Italy

Cited by 9 publications

References 30 publications

A Scientometric Evaluation of COVID-19 and Male Reproductive Research

A Scientometric Evaluation of COVID-19 and Male Reproductive Research

COVID-19 and Semen Fluid Parameters, a Retrospective Study from Infertility Clinics

COVID-19: the possibility, ways, mechanisms, and interruptions of mother-to-child transmission

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