Assessment of risk factors associated with fatty liver disease

Xiang, Guoqing; Meng, Xin; Zhang, Hao; Tai, Wen-Xia; Meng, Xiaoxiao; Wang, Bingyuan

doi:10.11569/wcjd.v17.i10.1038

Cited by 3 publications

(4 citation statements)

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“…BMI has been regarded as an indicator of the overall obesity and present study showed prevalence of NAFLD in total population increased with BMI levels, obesity people have prevalence of 33.2%, nearly 5 times higher than normal people. This was in line with the research from Lin [40] and Xiang [41] .…”

Section: Discussionsupporting

confidence: 91%

Prevalence of Nonalcoholic Fatty Liver Disease and the Related Risk Factors in Chongqing, Southwest China

Yan

Yang

et al. 2023

Preprint

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Backgound. Prevalence of Nonalcoholic fatty liver disease (NAFLD) in China is increasing recently, and the prevalence rate and the related risk factors of it are significantly different among regions in China. Epidemiological characteristics of NAFLD in Chongqing, a southwest city of China has not been fully revealed up to now. We conducted the present study to investigate the prevalence of NAFLD and its risk factors among the population in Chongqing. Methods. A total of 74,870 healthy adults(38,952 men and 35,918 women, mean age: 38.69 ± 14.38 years) from a grade 3 hospital in Chongqing, China were included in the present study. All of the participants underwent anthropometric measurements, liver ultrasonography and serum examinations. Student-T test, chi-square test and logistic regression were used for statistical analysis. Results. The prevalence rate of NAFLD was 13.1% (9,752/74,870) with an increasing trend with age (P for trend < 0.001). Prevalence of NAFLD for men was estimated to be 3.0 times higher than women(19.1% for men and 6.3% for women,χ2 = 2726.65, P < 0.001). Gender, age, hypertension, fasting blood glucose (FBG), serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and alanine transarninase (ALT) were independently correlated with the risk of NAFLD in the overall population. Among these factors, age, hypertension, FBG, TG, HDL-C, LDL-C and ALT were significantly associated with NAFLD both in male and female population. HDL-C was an independent risk factor of NAFLD for men,but not for women. Age(> 50 years) is the strongest associated factor both for male(OR 3.46) and female(OR 15.08). Conclusions. The prevalence of NAFLD among healthy adults in Chongqing,China was relatively high. Our results suggest that individuals in this region with higher BMI, higher FBG, hypertension, hypertriglyceridemia, and elevated ALT should pay high attention to NAFLD.

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Section: Discussionsupporting

confidence: 91%

Prevalence of Nonalcoholic Fatty Liver Disease and the Related Risk Factors in Chongqing, Southwest China

Yan

Yang

et al. 2023

Preprint

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“…[ 36 ] Subcutaneous fat is an important indicator of upper body fat content. [ 37 ] Xiang et al [ 38 ] have shown that the risk of fatty liver in overweight, degree I obesity, and degree II obesity group increased by 1.7, 1.9, and 9.1 times, respectively, compared with the normal body mass group. Ma et al [ 39 ] have found that the risk of fatty liver is higher in people with large waist circumference (>85 cm in male and >80 cm in female).…”

Section: Discussionmentioning

confidence: 99%

Risk factors and community intervention for nonalcoholic fatty liver disease in community residents of Urumqi, China

Lin¹,

Xian²,

Liu

et al. 2018

Medicine

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This study is to investigate the prevalence and risk factors of nonalcoholic fatty liver disease (NAFLD) and to analyze the effect of comprehensive community intervention on NAFLD in community residents in Urumqi, China.Cluster sampling method with street community as a unit was adopted in this study. Questionnaire survey, body measurement, blood biochemistry (including liver function, fasting blood glucose [FPG], and uric acid [UA]) examination as well as liver B ultrasound were performed. Then, comprehensive intervention was conducted in NAFLD patients.A total of 1000 people were enrolled, including 344 men and 656 women, with an average age of 51.79 ± 4.28 years. Of them, 660 were Han Chinese, 327 were Uygur, and 13 were Hui. The overall prevalence rate of NAFLD was 54.3%. The prevalence rate of NAFLD is higher in middle-aged population and is higher in ethnic minority than that in Han. NAFLD was associated with the past medical history of metabolic diseases. The factors of body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), waist circumference, hip circumference, neck circumference, subcutaneous fat thickness, FPG, alanine aminotransferase, and aspartate aminotransferase were identified as risk factors for NFALD. Neck circumference predicts the occurrence of NAFLD in female better, whereas subcutaneous fat predicts the occurrence of NAFLD in male better. After 8 months of community intervention in NAFLD patients, the changes of BMI, SBP, DBP, waist circumference, neck circumference, subcutaneous fat thickness, and UA were statistically significant (P < .05).The prevalence rate of NAFLD is high in Urumqi, China. Community intervention is effective in reducing the degree of NAFLD and promoting the overall health of NAFLD patients.

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“…Obesity is considered the most prominent and independent risk factor for NAFLD. Among obese patients with a BMI >30 kg/m 2 , the prevalence of NAFLD is over 91% [ [28] , [29] , [30] ]. Ma et al [ 31 ] reported that the risk for NAFLD increased 1.7, 1.9, and 9.1-fold in overweight, grade 1 obese, and grade 2 obese patients, respectively, compared with the normal BMI group.…”

Section: Discussionmentioning

confidence: 99%

“…Ma et al [ 31 ] reported that the risk for NAFLD increased 1.7, 1.9, and 9.1-fold in overweight, grade 1 obese, and grade 2 obese patients, respectively, compared with the normal BMI group. Increased waist circumference, an indicator of abdominal fat accumulation, is a risk factor for fatty liver in many studies [ 30 , 32 ]. Neck circumference, a significant predictor of metabolic syndrome and NAFLD, is a valid substitute for measuring subcutaneous fat storage in the upper body [ [33] , [34] , [35] ].…”

Section: Discussionmentioning

confidence: 99%

The association of Neuromedin U levels and non-alcoholic fatty liver disease: A comparative analysis

Keskin,

Avul,

Beyaz

et al. 2024

Heliyon

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Assessment of risk factors associated with fatty liver disease

Cited by 3 publications

References 0 publications

Prevalence of Nonalcoholic Fatty Liver Disease and the Related Risk Factors in Chongqing, Southwest China

Prevalence of Nonalcoholic Fatty Liver Disease and the Related Risk Factors in Chongqing, Southwest China

Risk factors and community intervention for nonalcoholic fatty liver disease in community residents of Urumqi, China

The association of Neuromedin U levels and non-alcoholic fatty liver disease: A comparative analysis

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