Assessment of Prescription Pattern of Antidiabetic Drugs in the Outpatient Department of a Tertiary Care Hospital

Kakade, Ashutosh; Mohanty, Ipseeta Ray; Rai, Sandeep

doi:10.17352/ijcem.000021

Cited by 13 publications

(15 citation statements)

References 13 publications

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“…In this study monotherapy form of AHA (69.42%) was more preferred than FDC(30.58%) form. This was in contrast to a study 24 conducted in Mumbai, where FDCs were more preferred (60%) than monotherapy. However various studies 19,21 noted more prevalence of monotherapy over FDCs.…”

Section: Discussioncontrasting

confidence: 98%

“…Majority of the prescribed FDCs in the present study contains metformin, which is true in various other similar studies. 24,21 In current study newer class of AHA were least prescribed, that too as a part of FDCs and not as monotherapy form. This observation was also noted in a study conducted by Agarwal et al 27 where less number of newer classes of AHA were prescribed.…”

Section: Discussionmentioning

confidence: 73%

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2019

MIJOPHAR

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Background: Diabetes is becoming major public health problem in low-and middle-income countries. India shares the highest burden of diabetic cases in the world. Diabetes over a period leads to various organ system complication, thereby increasing treatment cost. Hence it's prudent to have rational drug utilization pattern in diabetes cases especially in rural areas. This study aims to assess the same. Material and Methods: Prospective, observational Pharmaco-epidemiological study was carried out in Medicine outpatient department for a period of two months and 200 Antihyperglycemic agents (AHA) containing prescriptions pattern were studied. Drug Utilization (DU) 90% was used to assess rationality of prescription and was calculated based on defined daily dose (DDD) with their respective value in Anatomical Therapeutic Chemical (ATC) classification code. Defined daily dose is calculated as DDD/1000/day. Results: Monotherapy forms (69.42%) of AHA were more preferred than combination form (30.58%). Metformin was the commonest AHA prescribed. Glimepiride+Metformin+Voglibose is the commonest Fixed dose combination of AHA prescribed. Cost of AHA per prescription was 170.20rs. 50% of prescribed AHA constituted to DU90% segment. Conclusion: Newer class of AHA were least preferred. More generic drug prescription needed to bring down cost of AHA per prescription. Prescription was largely rational as not more than 50% of prescribed AHA constituted to DU90%.

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Section: Discussioncontrasting

confidence: 98%

Section: Discussionmentioning

confidence: 73%

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2019

MIJOPHAR

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“…Commonly metformin and sulfonylureas (mainly glimepiride) are widely used for the treatment of T2DM in India and this use is as per guideline recommendations. 6,7 However these drugs are associated with side effects like weight gain and hypoglycemia with sulfonylureas and gastrointestinal upset with metformin, which may largely restrict the ability to intensify therapy and attain stringent glycemic target. 3 therapies for the treatment of T2DM have advantages of weight loss, low risk of hypoglycemia and cardiovascular benefit.…”

Section: Discussionmentioning

confidence: 99%

“…This is in line with Indian studies which have shown that metformin and glimepiride are the most commonly prescribed anti-hyperglycemic agents followed by voglibose. 6,7 However there has been trend of increasing use of teneligliptin with metformin in Korean and Japanese population as well. 17,18 Real-world evidence supplements Randomized controlled trials (RCT) data and adds to clinical evidence regarding clinical efficacy of a drug.…”

Section: Discussionmentioning

confidence: 99%

A study to assess clinical profile of Indian type 2 diabetes mellitus patients treated with Teneligliptin-ASPIRE study

Chadha¹,

Dhediya

Saxena

et al. 2019

Int J Basic Clin Pharmacol

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Background: Teneligliptin is a DPP-4 inhibitor with unique chemical structure. Efficacy and safety of Teneligliptin is well established in the patients with type 2 diabetes mellitus (T2DM) in different randomized controlled trials. However, limited real-world data is available for Teneligliptin pertaining to Indian T2DM patient profile such as demographics, duration of disease, currently prescribed anti-hyperglycemic drugs, initiation of Teneligliptin as monotherapy or as an add on therapy.Methods: A cross-sectional, multicenter, non-interventional study was conducted to understand the demographics and clinical profile of Indian T2DM patients (n=5091) who were prescribed Teneligliptin.Results: Majority of patients were male (65.2%) with family history of T2DM present in 43.45% of cases. Age at onset of T2DM was 51.1±11.6 years. Among the T2DM patients, 36.2% of patients were newly diagnosed and more than half of them (54.7%) were uncontrolled with current anti-hyperglycemic drugs. Mean HbA1c level among these patients was 8.09±1.3%. Mean fasting and postprandial blood glucose levels were 170.2±46.9 mg/dl and 255.3±69.3 mg/dl respectively. Teneligliptin was prescribed as monotherapy in 2165 (41.66 %) of patients while as dual, triple and quadruple therapy in 2346 (46.08%) and 551 (10.82%) and 29 (0.56%) respectively. Among the patients on current anti-hyperglycemic treatment, most commonly prescribed drugs along with Teneligliptin were metformin (43.39%) followed by glimepiride (11%) and voglibose (3.42%).Conclusions: Teneligliptin is preferred as monotherapy and combination with metformin and sulfonylureas (mostly glimepiride) in newly diagnosed and uncontrolled T2DM patients in Indian scenario.

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“…Hence the knowledge of how drugs are prescribed just after the graduation of doctors will help in identifying concerns if any addressing rational drug use or suggest measures to improve prescribing habits after their graduation. 13…”

Section: Introductionmentioning

confidence: 99%

Anti-diabetic drugs prescription pattern by postgraduate students among type 2 diabetes patients attending a tertiary care hospital

Somashekar

Kumar

et al. 2019

Int J Basic Clin Pharmacol

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Background: The pattern of prescribing anti-diabetic drugs varies among different medical professionals due to the availability of numerous anti-diabetic drugs and demographic and have increasingly favoured for tighter control of glycemic index. Even with the available multiple therapies many patients are not in control. The reasons may be multi factorial and the one important factor is the drugs prescribed.Methods: This cross-sectional study involving 140 type 2 adult diabetes patients was done to assess the pattern of anti-diabetic drugs prescribed by the postgraduate students in a tertiary health care center using a specially designed questionnaire.Results: Oral medications were predominantly prescribed. Metformin and Glimepiride combination was prescribed in majority. Among insulin, combination of short and intermediate acting insulin was prescribed more and the number of insulin prescription increased with the duration of diabetes. Interestingly no newer classes of drugs are prescribed.Conclusions: There is a rational prescription pattern of antidiabetic drugs but newer antidiabetic drugs are not prescribed and life style changes are not discussed with the patients. There is a need to include life style changes as a part of prescription to all the patients.

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Assessment of Prescription Pattern of Antidiabetic Drugs in the Outpatient Department of a Tertiary Care Hospital

Cited by 13 publications

References 13 publications

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A study to assess clinical profile of Indian type 2 diabetes mellitus patients treated with Teneligliptin-ASPIRE study

Anti-diabetic drugs prescription pattern by postgraduate students among type 2 diabetes patients attending a tertiary care hospital

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