Assessment of prenatal stress‐related cortisol exposure: focus on cortisol accumulation in hair and nails

Meyer, Jerrold S.; Novak, Melinda A.

doi:10.1002/dev.22021

Cited by 23 publications

(21 citation statements)

References 170 publications

(261 reference statements)

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“…Accordingly, we will quantify blood cortisol levels as a measure of an acute stress provoked by the suicide attempt, and, in collaboration with the University Hospital of Bordeaux, we will assess hair cortisol, as a retrospective indicator of cumulative cortisol levels during the last 3 months preceding the attempt. To date, hair cortisol has been used in various settings as a reliable marker of long-term exposure to stress (46)(47)(48). A recent meta-analysis investigating the association between hair cortisol levels and depression found contradictory results (49).…”

Section: Discussionmentioning

confidence: 99%

Investigating Predictive Factors of Suicidal Re-attempts in Adolescents and Young Adults After a First Suicide Attempt, a Prospective Cohort Study. Study Protocol of the SURAYA Project

et al. 2022

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IntroductionSuicide is the fourth leading cause of death in youth. Previous suicide attempts are among the strongest predictors of future suicide re-attempt. However, the lack of data and understanding of suicidal re-attempt behaviors in this population makes suicide risk assessment complex and challenging in clinical practice. The primary objective of this study is to determine the rate of suicide re-attempts in youth admitted to the emergency department after a first suicide attempt. The secondary objectives are to explore the clinical, socio-demographic, and biological risk factors that may be associated with re-attempted suicide in adolescents and young adults.MethodsWe have developed a single-center prospective and naturalistic study that will follow a cohort of 200 young people aged 16 to 25 years admitted for a first suicide attempt to the emergency department of Lyon, France. The primary outcome measure will be the incidence rate of new suicide attempts during 3 months of follow-up. Secondary outcomes to investigate predictors of suicide attempts will include several socio-demographic, clinical and biological assessments: blood and hair cortisol levels, plasma pro- and mature Brain-Derived Neurotrophic Factor (BDNF) isoforms proportion, previous infection with toxoplasma gondii, and C-Reactive Protein (CRP), orosomucoid, fibrinogen, interleukin (IL)-6 inflammatory markers.DiscussionTo our knowledge, the present study is the first prospective study specifically designed to assess the risk of re-attempting suicide and to investigate the multidimensional predictive factors associated with re-attempting suicide in youth after a first suicide attempt. The results of this study will provide a unique opportunity to better understand whether youth are an at-risk group for suicide re-attempts, and will help us identify predictive factors of suicide re-attempt risk that could be translated into clinical settings to improve psychiatric care in this population.Clinical Trial RegistrationClinicalTrials.gov, identifier: NCT03538197, first registered on 05/29/2018. The first patient was enrolled 05/22/2018.

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Section: Discussionmentioning

confidence: 99%

Investigating Predictive Factors of Suicidal Re-attempts in Adolescents and Young Adults After a First Suicide Attempt, a Prospective Cohort Study. Study Protocol of the SURAYA Project

et al. 2022

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“…Cortisol levels can be measured in many different bodily fluids and tissues, including blood, urine, saliva, feces, sweat, hair, and fingernails. As noted in Table 1 , these sample matrices differ with respect to the time frame they represent, the cortisol fraction being measured, units of measure, and susceptibility to being influenced by circadian rhythms ( Novak et al, 2013 ; Meyer and Novak, 2021 ).…”

Section: The Model Of Self-injury In Rhesus Monkeysmentioning

confidence: 99%

A Rhesus Monkey Model of Non-suicidal Self-Injury

Novak

Meyer

2021

Front. Behav. Neurosci.

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Non-suicidal self-injury (NSSI) is a type of behavioral pathology seen not only in a variety of clinical conditions but also among non-clinical populations, particularly adolescents and young adults. With the exception of rare genetic conditions that give rise to self-harming behaviors, the etiology of NSSI and the events that trigger specific episodes of this behavior remain poorly understood. This review presents the features of an important, extensively studied animal model of NSSI, namely spontaneously occurring self-injurious behavior (SIB) in rhesus macaque monkeys. We compare and contrast rhesus monkey SIB with NSSI with respect to form, prevalence rates, environmental and biological risk factors, behavioral correlates, proposed functions, and treatment modalities. Many parallels between rhesus monkey SIB and NSSI are demonstrated, which supports the validity of this animal model across several domains. Determining the etiology of spontaneously occurring SIB in monkeys, its underlying biological mechanisms, and which pharmacological agents are most effective for treating the disorder may aid in identifying potential risk factors for the occurrence of NSSI in humans and developing medications for severe cases that are resistant to conventional psychotherapeutic approaches.

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“…This work offers a non-invasive approach to study predictive and risk biomarkers in neonates of postnatal disorders resulting from pre-and perinatal stress. An excellent review recently focused on cortisol accumulation in the hair and nails of mothers and babies [94], while Liu & Doan [95] have examined the relationship between stress biomarkers in hair and nails.…”

Section: Stress and Depressionmentioning

confidence: 99%

Biomarkers of disease in human nails: a comprehensive review

Ortiz

Howsam

Aken

et al. 2021

Critical Reviews in Clinical Laboratory Sciences

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Diagnostic, monitoring, response, predictive, risk and prognostic biomarkers of disease are all widely studied, for the most part in biological fluids or tissues, but with steadily growing interest in alternative matrices of which nails are an example. Here we comprehensively review studies dealing with molecular or elemental biomarkers of disease, as opposed to semiological, pharmacological, toxicological or biomonitoring studies.Nails have a long history of use in medicine as indicators of pathological processes, and have also been used extensively as a matrix for monitoring exposure to environmental pollution.Nail clippings are simple to collect non-invasively, to transport and to store, and the matrix itself is relatively stable. Nails incorporate, and are influenced by, circulating molecules and elements over their several months' of growth, and it is widely held that markers of biological processes thus included will remain in the nail, even when their levels in blood have declined.They thus offer the possibility, not only of looking back into a subject's metabolic history, but also of studying biomarkers of processes that operate over a longer time scale such as the posttransational modification of proteins.Reports on ungual biomarkers of metabolic and endocrine diseases, cancer, and psychological and neurological disorders will be presented, and an overview of the sampling and analytical techniques provided.

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Assessment of prenatal stress‐related cortisol exposure: focus on cortisol accumulation in hair and nails

Cited by 23 publications

References 170 publications

Investigating Predictive Factors of Suicidal Re-attempts in Adolescents and Young Adults After a First Suicide Attempt, a Prospective Cohort Study. Study Protocol of the SURAYA Project

Investigating Predictive Factors of Suicidal Re-attempts in Adolescents and Young Adults After a First Suicide Attempt, a Prospective Cohort Study. Study Protocol of the SURAYA Project

A Rhesus Monkey Model of Non-suicidal Self-Injury

Biomarkers of disease in human nails: a comprehensive review

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