Assessment of Prealbumin in Hemodialysis and Renal-Transplant Patients

Chrysostomou, Smaragda; Stathakis, C; Petrikkos, George; Daikos, George L.; Gompou, Athina; Perrea, Despina

doi:10.1053/j.jrn.2009.04.001

Cited by 13 publications

(8 citation statements)

References 26 publications

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“…In contrast to serum albumin, however, its half-life is relatively short (~2 to 3 days). It has therefore been suggested that prealbumin may be a more sensitive indicator of nutritional status than either serum albumin or transferrin 3,37. In our study, prealbumin levels correlated with nPCR, nutrition index and illness marker.…”

Section: Discussionsupporting

confidence: 58%

Comparison of Nutritional Parameters among Adult and Elderly Hemodialysis Patients

Çelik¹,

Öç²,

Kara³

et al. 2011

Int. J. Med. Sci.

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Aim: The aim of this study was to compare the nutritional biochemical parameters, prealbumin levels, and bioimpedance analysis parameters of adult and elderly hemodialysis (HD) patients.Methods: This prospective cross-sectional study included 50 adult HD patients (42.0 % female). Nutritional status was assessed by post-dialysis multifrequency bioimpedance analysis (BIA), serum prealbumin and other nutritional biochemical parameters.Results: Mean age of patients was 57.4±15.1 years (range: 30-83 years) and mean dialysis duration was 68.3 ± 54.5 months (range: 3-240 months). When the patients were divided into two groups according to age of patients (<65 and ≥65), prealbumin (p=0.003), blood urea nitrogen (BUN) (p=0.000), serum creatinine (p=0.013), albumin (p=0.016), protein catabolic rate per normalized body weight (nPCR) (p=0.001), intracellular water (ICW)/total body weight (0.003) , body fat mass (p00.000), lean body mass (p=0.031), lean dry mass (p=0.001), illness marker (p=0.005), basal metabolism (p=0.007), body mass index (BMI) (p=0.028), body fat mass index (BFMI) (p=0.000), fat free mass index (FFMI) (p=0.040) values were significantly different between the groups. In the elderly patients (age ≥65), body fat mass, illness marker, BMI, BFMI were higher compared to adult patients (age <65). Additionally, in the elderly patients, prealbumin, BUN, creatinine, albumin, nPCR, ICW/ total body weight, lean body weight, lean dry weight, basal metabolism and FFMI were lower than adult patients.Conclusions: Our results indicate that BFMI were higher, albumin, prealbumin, nPCR and lean body mass and FFMI were lower in elderly patients compared to adults. These results imply that elderly HD patients may be prone sarcopenic obesity and may require special nutritional support.

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Section: Discussionsupporting

confidence: 58%

Comparison of Nutritional Parameters among Adult and Elderly Hemodialysis Patients

Çelik¹,

Öç²,

Kara³

et al. 2011

Int. J. Med. Sci.

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“…As in many previous studies, serum PA was thought superior to albumin in assessing an individual’s recent nutritional intake and current nutritional state [10] , [11] , [31] as it has a shorter biological half-life. Furthermore, serum PA insufficiency was also reported relating to higher recurrence risk after surgery [32] , liver cirrhosis [9] , [33] , inflammatory processes [34] , wound healing [35] , kidney injury [36] , [37] , [38] and liver insufficiency [39] . As liver damage was a common side effect in the process of anti-TB, serum PA was considered to be a sensitive indictor to predict early liver injury caused by anti-TB drugs.…”

Section: Discussionmentioning

confidence: 99%

The Value of Serum Prealbumin in the Diagnosis and Therapeutic Response of Tuberculosis: A Retrospective Study

et al. 2013

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ObjectiveThe aim of this study was to examine serum prealbumin (PA) levels in patients with tuberculosis and lung cancer, and to evaluate the correlations of serum PA levels with clinicopathological characteristics.MethodTotal 760 patients were included in the study: 320 patients with tuberculosis, 320 patients with lung cancer, and 120 healthy subjects. Serum PA was detected using a biochemical analyzer to determine the value of serum PA in the diagnosis and therapeutic response of tuberculosis.ResultsCompared to lung cancer and healthy individuals, TB patients were more frequent in suffering from low serum PA (75.0% vs.30.9% vs.6.7%,P<0.01), and the serum PA levels of TB patients were significantly reduced (137.5±42.4 mg/L vs. 183.5±49.1 mg/L vs. 240.0±43.9 mg/L, P<0.01). Among various clinical characteristics, type (with pleuritis), age (≥60), ESR (>20 mm/h) and smoking status (≥20 pack×years) were associated with low serum PA levels of TB patients, while ECOG performance status (≥2) was associated with low serum PA levels of lung cancer patients. The change of serum PA levels was in accordance with the therapeutic effects of anti-TB drugs, which might present a valuable and objective indicator for monitoring the therapeutic effects of TB drugs on TB patients.ConclusionLow serum prealbumin levels are very common in TB patients and can be served as a potential indicator for differential diagnosis of lung cancer and monitoring the therapeutic effects of TB drugs.

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“…Reaction protein, APRP) including CRP, transferrin protein, amyloid protein A and prealbumin (PA). Serum PA is a highly sensitive marker of nutrition and survival in dialysis patients [11,12]. This article's purpose was to evaluate the relationship between serum PA and the prognosis of young cerebral infarction patients.…”

Section: Discussionmentioning

confidence: 99%

Serum prealbumin (transthyretin) predict good outcome in young patients with cerebral infarction

Gao

Zhang

et al. 2010

Clin Exp Med

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Low serum protein and albumin are considered to significantly associate with malnutrition, impaired functional status, poor outcome, and mortality. We hypothesized that serum prealbumin (transthyretin, PA) was a reliable and robust survival marker in young cerebral infarction patients and attempted to test the foregoing hypothesis. We analyzed the relationship between serum PA and stroke severity as determined by the modified Rankin Scale at discharge in 585 young cerebral infarction patients. By multivariate logistic regression modeling, we determined the influence of prealbumin on stroke severity, and the analyses were adjusted for the effects of potential confounders. Patients with a severe stroke had significantly more often prealbumin on admission in the lowest quintile (P = 0.031). Those cardiogenic cerebral infarction patients had significantly lower serum prealbumin concentrations and higher mRS scores. A logistic regression adjusted for confounders confirmed the following independent (odds ratio, 95% CI) good outcome predictors: uric acid (-0.002, 0.996-1.000) and prealbumin (-0.003, 0.995-1.000). Prealbumin is an independent predictor of the good clinical outcome of young cerebral infarction patients. The serum prealbumin may be a useful prognostic indicator for judging the prognosis of cerebral infarction.

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Assessment of Prealbumin in Hemodialysis and Renal-Transplant Patients

Cited by 13 publications

References 26 publications

Comparison of Nutritional Parameters among Adult and Elderly Hemodialysis Patients

Comparison of Nutritional Parameters among Adult and Elderly Hemodialysis Patients

The Value of Serum Prealbumin in the Diagnosis and Therapeutic Response of Tuberculosis: A Retrospective Study

Serum prealbumin (transthyretin) predict good outcome in young patients with cerebral infarction

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