Assessment of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans in Down′s syndrome subjects and systemically healthy subjects: A comparative clinical trial

Ahmed, Nizar; Parthasarathy, Harinath; Arshad, Mohamed; Victor, Dhayanand John; Mathew, Danny; Sankari, Siva

doi:10.4103/0972-124x.147408

Cited by 6 publications

(4 citation statements)

References 15 publications

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“…Among the twenty-six studies considered (all observational studies) published between 1968 and 2021, four were performed in the U.S.A. [56,58,65,72] and in Japan [59,63,66,69], three in Spain [15,51,52], Brazil [64,76,77] and in India [61,74,78], two in Sweden [57,67] and in Greece [68,70], and the remaining came from Germany [60], the Netherlands [67], Saudi Arabia [71], Mexico [73] and Iran [75]. Most observational studies were cross-sectional case/control studies comparing periodontal and microbial features of DSof various ages-with systematically healthy controls (HC), and/or subjects affected by mental retardations (MR) or cerebral palsy (CP).…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

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Oral Microbiota Features in Subjects with Down Syndrome and Periodontal Diseases: A Systematic Review

Contaldo

Lucchese

Romano

et al. 2021

IJMS

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Down syndrome (DS) is a genetic disorder associated with early-onset periodontitis and other periodontal diseases (PDs). The present work aimed to systematically review the scientific literature reporting studies in vivo on oral microbiota features in subjects with DS and related periodontal health and to highlight any correlation and difference with subjects not affected by DS, with and without PDs. PubMed, Web of Science, Scopus and Cochrane were searched for relevant studies in May 2021. The participants were subjects affected by Down syndrome (DS) with and without periodontal diseases; the study compared subjects with periodontal diseases but not affected by DS, and DS without periodontal diseases; the outcomes were the differences in oral microbiota/periodontopathogen bacterial composition among subjects considered; the study design was a systematic review. Study quality was assessed with risk of bias in non-randomized studies of interventions (ROBINS-I). Of the 954 references retrieved, 26 studies were considered. The conclusions from the qualitative assessment of the papers revealed an increasing knowledge over the last years of the microbiota associated with DS and their periodontal diseases, in comparison with healthy subjects and subjects with other kinds of mental disabilities. Few data have emerged on the mycobiome and virobiome of DS, hence, further investigations are still necessary.

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Section: Characteristics Of the Studiesmentioning

confidence: 99%

“…In 2014, Ahmed et al [74] from India compared and quantified the presence of two periodontal pathogens-A. actinomycetemcomitans and P. gingivalis in P-DS, G-DS, P-HC, and G-HC.…”

Section: Outcomementioning

confidence: 99%

Oral Microbiota Features in Subjects with Down Syndrome and Periodontal Diseases: A Systematic Review

Contaldo

Lucchese

Romano

et al. 2021

IJMS

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“…Although aggressive periodontitis shows characteristic clinical features similar to those of the population who do not suffer from the syndrome, special features in periodontal pathogens have been identified, such as an increase in Porphyromonas gingivalis (Pg) and Aggregatibacter actinomycetemcomitans (Aac) in these patients compared to patients who do not suffer from trisomy of chromosome 21 (T-21) but who do present aggressive periodontitis [2]. Other species, such as Fusobacterium nucleatum (Fn), Prevotella nigrescens , or Actinomyces naeslundii , are also present in these individuals more often than in those who do not suffer from T-21 [3].…”

Section: Introductionmentioning

confidence: 99%

Differential Expression of Inflammation-Related Genes in Down Syndrome Patients with or without Periodontal Disease

Baus-Domínguez

Gómez-Díaz

Torrés-Lagares

et al. 2019

Mediators of Inflammation

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Aim Aware that Down Syndrome patients present among their clinical characteristics impaired immunity, the aim of this study is to identify the statistically significant differences in inflammation-related gene expression by comparing Down Syndrome patients with Periodontal Disease (DS+PD+) with Down Syndrome patients without Periodontal Disease (DS+PD-), and their relationship with periodontitis as a chronic oral inflammatory clinical feature. Materials and Methods Case study and controls on eleven Down Syndrome patients (DS+PD+ vs. DS+PD-). RNA was extracted from peripheral blood using a Qiagen PAXgene Blood miRNA Kit when performing an oral examination. A search for candidate genes (92 selected) was undertaken on the total genes obtained using a Scientific GeneChip® Scanner 3000 (Thermo Fisher Scientific) and Clariom S solutions for human, mouse, and rat chips, with more than 20,000 genes annotated for measuring expression levels. Results Of the 92 inflammation-related genes taken initially, four genes showed a differential expression across both groups with a p value of <0.05 from the data obtained using RNA processing of the patient sample. Said genes were TNFSF13B (p = 0.0448), ITGB2 (p = 0.0033), ANXA3 (p = 0.0479), and ANXA5 (p = 0.016). Conclusions There are differences in inflammation-related gene expression in Down Syndrome patients when comparing patients who present a state of chronic oral inflammation with patients with negative rates of periodontal disease.

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“…A comparative clinical trial found increased presence of P.g. in DS patients with periodontitis [ 18 ]. The role of INS can be supported by the fact that supernatants of potential periodontal pathogens, i.e., P.g.…”

Section: Discussionmentioning

confidence: 99%

Identification of Neuropeptides as Potential Crosstalks Linking Down Syndrome and Periodontitis Revealed by Transcriptomic Analyses

Chen

Kong

2021

Disease Markers

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Background. This bioinformatics study was aimed to investigate the relationship between periodontitis (PD) and Down Syndrome (DS) regarding potential crosstalk genes, related neuropeptides, and biological processes. Methods. Data for PD (GSE23586, GSE10334 and GSE16134) and DS (GSE35665) were downloaded from NCBI Gene Expression Omnibus (GEO). Following normalization and merging of PD data, differential expression analysis was performed ( p value < 0.05 and ∣ log FC ∣ ≥ 0.5 ). The common deregulated genes between PD and DS were considered as crosstalk genes. The significantly differentially expressed genes were used to construct the coexpression network and to further identify coexpression gene modules. To acquire the significant modules, the significant expression level of genes in the module was used to analyze the enrichment of genes in each module. Neuropeptides were assessed from NeuroPedia database. Neuropeptide genes and crosstalk genes were merged and mapped into PPI network, and the correlation coefficient (Spearman) was determined for the crosstalk genes. Results. 138 crosstalk genes were predicted. According to the functional enrichment analysis, these genes significantly regulated different biological processes and pathways. In enrichment analysis, the significant module of DS was pink module, and turquoise module was significant in PD. Four common crosstalk genes were acquired, i.e., CD19, FCRL5, FCRLA, and HLA-DOB. In the complex network, INS and IGF2 interacted with CASP3 and TP53, which commonly regulated the MAPK signaling pathway. Moreover, the results showed that TP53 interacted with IGF2 and INS inducing the dysregulation of PI3K-Akt signaling pathway. UBL was positively correlated with crosstalk genes in both diseases. LEP was revealed to be both a neuropeptide and crosstalk gene and was positively correlated with other crosstalk genes. Conclusion. Different crosstalk genes, related neuropeptides, and biological pathways and processes were revealed between PD and DS, which can serve as a theoretical basis for future research.

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Assessment of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans in Down′s syndrome subjects and systemically healthy subjects: A comparative clinical trial

Cited by 6 publications

References 15 publications

Oral Microbiota Features in Subjects with Down Syndrome and Periodontal Diseases: A Systematic Review

Oral Microbiota Features in Subjects with Down Syndrome and Periodontal Diseases: A Systematic Review

Differential Expression of Inflammation-Related Genes in Down Syndrome Patients with or without Periodontal Disease

Identification of Neuropeptides as Potential Crosstalks Linking Down Syndrome and Periodontitis Revealed by Transcriptomic Analyses

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