Assessment of Placental Oxidative Stress in Pre-Eclampsia

Das, Brahmarshi; Saha-Roy, Santa; Gupta, Anindya Das; Lahiri, T. K.; Das, Harendra Nath

doi:10.1007/s13224-012-0150-z

Cited by 16 publications

(7 citation statements)

References 11 publications

(14 reference statements)

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“…As with other oxidative stress metabolites, levels of antioxidant enzymes and compounds, such as catalase, superoxide dismutase (SOD) and vitamin E have been found to be variable in PE studies compared to normal pregnancies (Bilodeau, 2014 ). For example, in a study performed in India, SOD activity, measured in placental tissue and serum from preeclamptic women was found to be 1.4 times higher than in control samples, while glutathione levels remained unchanged (Das et al, 2012 ). However, other studies have reported that both SOD (Tortladze et al, 2013 ; Bilodeau, 2014 ) and catalase activity are decreased in women with PE (Skoczylas-Pietrzyk et al, 1998 ).…”

Section: Placental and Maternal Antioxidant Defenses In Pementioning

confidence: 99%

Endothelial dysfunction and preeclampsia: role of oxidative stress

et al. 2014

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Preeclampsia (PE) is an often fatal pathology characterized by hypertension and proteinuria at the 20th week of gestation that affects 5–10% of the pregnancies. The problem is particularly important in developing countries in where the incidence of hypertensive disorders of pregnancy is higher and maternal mortality rates are 20 times higher than those reported in developed countries. Risk factors for the development of PE include obesity, insulin resistance and hyperlipidemia that stimulate inflammatory cytokine release and oxidative stress leading to endothelial dysfunction (ED). However, how all these clinical manifestations concur to develop PE is still not very well understood. The related poor trophoblast invasion and uteroplacental artery remodeling described in PE, increases reactive oxygen species (ROS), hypoxia and ED. Here we aim to review current literature from research showing the interplay between oxidative stress, ED and PE to the outcomes of current clinical trials aiming to prevent PE with antioxidant supplementation.

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Section: Placental and Maternal Antioxidant Defenses In Pementioning

confidence: 99%

Endothelial dysfunction and preeclampsia: role of oxidative stress

et al. 2014

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“…Supernatant was taken as sample for investigation. The values of parameters are expressed per milligram or gram of tissue protein [20] .…”

Section: Preparation Of Placenta Homogenatesmentioning

confidence: 99%

Serum Adropin Levels in a Preeclampsia Like L-Name Rat Model Treated with Sildenafil Citrate

Raafat

Fathy²

2018

The Medical Journal of Cairo University

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Background: Preeclampsia, a hypertensive disorder of pregnancy, is detrimental to both mother and fetus. Sildenafil been proposed as a potential therapy to reduce blood pressure and improve uteroplacental perfusion in preeclamptic patients. Adropin is a novel secreted energy homeostasis protein regulating carbohydrate, lipid and protein metabolism, maternal adropin levels in Preeclampsia were still controversy. Aim of the Work: To evaluate serum levels of adropin in preeclampsia-like rat model and in preeclamptic rats treated with Sildenafil and to investigate their associations with some inflammatory, oxidative stress, and metabolic parameters. Material and Methods: 32 pregnant rats were divided randomly into four groups (n=8): Control group, sildenafil treated group, L-NAME group to induce pre-eclampsia and L-NAME with sildenafil treated group. In all groups, maternal Body Mass Index (BMI), placental weights, fetal weights, maternal mean arterial blood pressure (MAP), total urinary proteins, serum glucose, insulin and calculated Homeostatic Model Assessment of Insulin Resistance index (HOMA-IR), serum urea, creatinine, Triglycerides (TGs), Total Cholesterol (TC), Low Density Lipoproteins-cholesterol (LDL-c), High Density Lipoproteins-cholesterol (HDL-c), C Reactive Protein (CRP), Endothelin-1 (ET-1), and adropin were measured, also placental Malondialdehyde (MDA) levels, and activities of the antioxidant enzymes Superoxide Dismutase (SOD) and glutathione peroxidase (GSH) in placental homogenates were determined plus histopathological examination of placental sections were done. Results: L-NAME induced preeclampsia in rats and they showed significant increase in MAP, total urinary proteins, serum levels of glucose, insulin, calculated HOMA-IR, serum urea, creatinine, CRP, ET-1, TGs, TC, LDL-c, adropin and placental tissue MDA with significant reduction in maternal BMI, placental weights, fetal weights, serum HDL-c and placental tissue SOD and GSH activities as compared to other groups, additionally, L-NAME treated and L-NAME + SILD treated groups revealed positive significant correlations between adropin levels and MAP, total urinary proteins, serum levels of urea, creatinine, CRP, ET-1, TGs, TC, LDL-c, and placental tissue MDA, however they showed negative correlations between adropin and BMI, placental weights, fetal

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“…At present, most of the study results obtained based on the third trimester of pregnancy and after the fetal delivery show that the oxidative stress markers (e.g., malondialdehyde) in the serum and placenta of pregnant women with preeclampsia increase significantly, while the levels of antioxidant markers (e.g., vitamin C and vitamin E) decrease significantly [ 13 – 16 ]. At present, the studies on the correlation between vitamin A and the hypertensive disorder complicating pregnancy (HDCP) are very controversial [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Plasma Levels of Vitamin A in Early Pregnancy and Correlationship with Hypertensive Disorder

Wang

Zhao

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. Analyzing the vitamin A content in early pregnancy and finding out the relationship between the serum levels of vitamin A of pregnant women and hypertensive disorder. Method. A total of 4,188 pregnant women who had took part in vitamin A testing in Miyun District Hospital from November 2016 to March 2020 were collected. The serum levels of vitamin A were determined by high performance liquid chromatography, and clinical and testing data were collected for statistical analysis. The original data outcome was finally analyzed with the SPSS. Results. 266 Hypertensive disorder cases and 2836 normal pregnancy cases were analyzed with 27 cases of twin pregnancy, 315 cases without follow-up and 744 of diabetic pregnancies excluded. The 266 women were divided into four groups: 110 women were diagnosed gestational hypertension, 65 women were diagnosed preeclampsia, 78 women were diagnosed pregnancy with chronic hypertension, and 13 women were diagnosed chronic hypertension with preeclampsia. The results shows that vitamin A level of the hypertensive group was 0.46(±0.08) mg/L, 0.47 (±0.012) mg/L, 0.47 (±0.09) mg/L, and 0.52 (±0.012) mg/L, respectively, while the level of normal group was 0.44 (±0.09) mg/L. We found that there were differences between the normal pregnant group and the preeclampsia group with statistical significance ( P < 0.05 ). The difference between the pregnancy with chronic hypertension group and the normal group was statistically significant ( P < 0.05 ). The difference between the chronic hypertension with preeclampsia group and the normal group was also statistically significant ( P < 0.05 ). Conclusion. Serum levels of vitamin A in early pregnant women have a certain correlation with the hypertensive disorder.

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Assessment of Placental Oxidative Stress in Pre-Eclampsia

Cited by 16 publications

References 11 publications

Endothelial dysfunction and preeclampsia: role of oxidative stress

Endothelial dysfunction and preeclampsia: role of oxidative stress

Serum Adropin Levels in a Preeclampsia Like L-Name Rat Model Treated with Sildenafil Citrate

Plasma Levels of Vitamin A in Early Pregnancy and Correlationship with Hypertensive Disorder

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