Assessment of perimenopausal depression: A review

Willi, Jürg; Ehlert, Ulrike

doi:10.1016/j.jad.2019.02.029

Cited by 44 publications

(25 citation statements)

References 76 publications

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“…In our study, one of the causes of this ostensible increase might be explained because they are close to perimenopause period. Huge life changes in this period might be related to endocrine metabolic, sexual activity, and even family conflicts that lead to anxiety and depression (Gyllstrom et al, 2007;Maki et al, 2018;Willi and Ehlert, 2019). Regarding basal stress levels evaluated through the PSQ questionnaire, both genders showed medium scores that means that men and women are inside the range of moderate stress (men 0.41 and women 0.38), although there were no significant differences.…”

Section: Discussionmentioning

confidence: 96%

Influence of Stress and Depression on the Immune System in Patients Evaluated in an Anti-aging Unit

et al. 2020

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Background: There is compelling evidence pointing out that stress and depression produce a dramatic impact on human well-being mainly through impairing the regular function of the immune system and producing a low-chronic inflammation status that favors the occurrence of infections, metabolic diseases, and even cancer. The present work aims to evaluate the stress/depression levels of some patients treated in an antiaging unit and detect any potential relationship with their immune system status prior of the implementation of a physical/psychological program designed to prevent health deterioration. Methods: We evaluated 48 patients (16 men and 32 women with a mean age of 55.11 ± 10.71 years) from middle-upper class from psychological and immunological points of view. In particular, we analyzed neutrophil chemotaxis and phagocytosis; lymphocyte chemotaxis and proliferation, and natural killer (NK) cell activity. Results: Women showed more depressive symptoms than men. Chemotaxis levels of lymphocytes and neutrophils in women showed a significant reduction compared with those in men. We also found a strong negative correlation between depression and NK cell function. This correlation was also significant independently of gender. Conclusion: We conclude that NK activity is affected at least by depression state, and we propose that a combined treatment consisting of cognitive behavioral therapy and physical activity programs might improve patient health deterioration.

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Section: Discussionmentioning

confidence: 96%

Influence of Stress and Depression on the Immune System in Patients Evaluated in an Anti-aging Unit

et al. 2020

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“…In turn, women with lower levels of resilience are suggested to be more affected by menopausal complaints like vasomotor symptoms or sleep disturbances. Such symptoms may then co-occur and have been shown to interact with depressed mood [17][18][19], suggesting the perimenopause as a window of vulnerability for mood disturbances [20]. Indeed, prevalence rates of depressed mood during the perimenopause are particularly high [21].…”

Section: Introductionmentioning

confidence: 99%

The Swiss Perimenopause Study – study protocol of a longitudinal prospective study in perimenopausal women

Willi

Süss

Ehlert

2020

womens midlife health

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Background: The perimenopause is associated with considerable biopsychosocial changes. The majority of women manage to adjust to these changes and cope well with the shift from reproductive to non-reproductive life. However, some women develop burdensome physical and psychological symptoms during the perimenopause. A strong link between menopausal complaints and depressed mood has been shown in this regard. To date, the decisive factors determining whether a woman will successfully achieve a healthy transition remain unclear. Thus, the purpose of this study is to investigate a range of theory-based markers related to health in perimenopausal women. Methods: The Swiss Perimenopause Study comprises a sample of 135 healthy perimenopausal women aged 40-56. A variety of health-related genetic, epigenetic, endocrinological, physiological, and psychosocial markers associated with the menopausal transition are investigated over a period of 13 months. Discussion: The Swiss Perimenopause Study will contribute to a better understanding of the biopsychosocial processes associated with the perimenopause, which should help to improve the clinical care of women undergoing the menopausal transition.

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“…There is an increased prevalence of depressive symptoms in peri- and postmenopausal women, 210 which may be related to altered immune-system activity during this time. In midlife-aged women during the menopausal transition, an increase in pro-inflammatory response was observed prior to development of first-onset depression, 211 suggestive of a potential cascading effect.…”

Section: Menopausal Transitionmentioning

confidence: 99%

Inflammation, depression and cardiovascular disease in women: the role of the immune system across critical reproductive events

Mattina

Lieshout

Steiner

2019

Therapeutic Advances in Cardiovascular Disease

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Women are at increased risk for developing depression and cardiovascular disease (CVD) across the lifespan and their comorbidity is associated with adverse outcomes that contribute significantly to rates of morbidity and mortality in women worldwide. Immunesystem activity has been implicated in the etiology of both depression and CVD, but it is unclear how inflammation contributes to sex differences in this comorbidity. This narrative review provides an updated synthesis of research examining the association of inflammation with depression and CVD, and their comorbidity in women. Recent research provides evidence of pro-inflammatory states and sex differences associated with alterations in the hypothalamic-pituitary-adrenal axis, the renin-angiotensin-aldosterone system and the serotonin/kynurenine pathway, that likely contribute to the development of depression and CVD. Changes to inflammatory cytokines in relation to reproductive periods of hormonal fluctuation (i.e. the menstrual cycle, perinatal period and menopause) are highlighted and provide a greater understanding of the unique vulnerability women experience in developing both depressed mood and adverse cardiovascular events. Inflammatory biomarkers hold substantial promise when combined with a patient's reproductive and mental health history to aid in the prediction, identification and treatment of the women most at risk for CVD and depression. However, more research is needed to improve our understanding of the mechanisms underlying inflammation in relation to their comorbidity, and how these findings can be translated to improve women's health.

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Assessment of perimenopausal depression: A review

Cited by 44 publications

References 76 publications

Influence of Stress and Depression on the Immune System in Patients Evaluated in an Anti-aging Unit

Influence of Stress and Depression on the Immune System in Patients Evaluated in an Anti-aging Unit

The Swiss Perimenopause Study – study protocol of a longitudinal prospective study in perimenopausal women

Inflammation, depression and cardiovascular disease in women: the role of the immune system across critical reproductive events

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