Assessment of perfluoroalkyl substances in placenta by coupling salt assisted liquid-liquid extraction with dispersive liquid-liquid microextraction prior to liquid chromatography-tandem mass spectrometry

Unveiling Distribution of Per- and Polyfluoroalkyl Substances in Matched Placenta-Serum Tetrads: Novel Implications for Birth Outcome Mediated by Placental Vascular Disruption

“…Although PFASs have been detected previously in various maternofetal specimens, data on placental PFASs remain poor. Several recent studies reported PFAS levels in whole or partial placentas in Spain, United States of America, and China, − ,, but region- or plate-specific profiles of PFASs in placenta are still lacking. In this study, the dominant compounds (i.e., PFOA and PFOS) within the different matrices are consistent with prior reports. ,,,, Results showed that plate-specific levels of PFOA (median: 4.57–4.58 ng/g ww), PFOS (1.67–1.81 ng/g ww) and 6:2 Cl-PFESA (0.40–0.41 ng/g ww) in the subchorionic and parabasal placenta samples were 5–30 times higher than previous reports on PFAS levels in the whole placenta (0.14–1.41 ng/g ww for PFOA, 0.35–0.95 ng/g ww for PFOS, and 0.08 ng/g ww for 6:2 Cl-PFESA), ,,, except for PFOS detected in placenta from Tianjin, China (7.32 ng/g ww) .…”

“…Several recent studies reported PFAS levels in whole or partial placentas in Spain, United States of America, and China, − ,, but region- or plate-specific profiles of PFASs in placenta are still lacking. In this study, the dominant compounds (i.e., PFOA and PFOS) within the different matrices are consistent with prior reports. ,,,, Results showed that plate-specific levels of PFOA (median: 4.57–4.58 ng/g ww), PFOS (1.67–1.81 ng/g ww) and 6:2 Cl-PFESA (0.40–0.41 ng/g ww) in the subchorionic and parabasal placenta samples were 5–30 times higher than previous reports on PFAS levels in the whole placenta (0.14–1.41 ng/g ww for PFOA, 0.35–0.95 ng/g ww for PFOS, and 0.08 ng/g ww for 6:2 Cl-PFESA), ,,, except for PFOS detected in placenta from Tianjin, China (7.32 ng/g ww) . Compared to previous reports for PFOA in maternal and cord serum with ranges of 1.05–5.6 ng/mL and 0.86–3.7 ng/mL, respectively, ,,− the median concentrations of PFOA (29.3 and 17.8 ng/mL) in maternal and cord serum of the present study were in higher or comparable levels.…”

“…Although PFASs have been detected previously in various maternofetal specimens, 18 data on placental PFASs remain poor. Several recent studies reported PFAS levels in whole or partial placentas in Spain, United States of America, and China, [33][34][35]53,54 but region-or plate-specific profiles of PFASs in placenta are still lacking. In this study, the dominant compounds (i.e., PFOA and PFOS) within the different matrices are consistent with prior reports.…”

Fluorinated boron nitride nanosheets as an inorganic matrix for the MALDI mass spectrometry analysis of perfluoroalkyl acids

“…PFAAs screening is significantly important to the studies of environmental development and public health [30]. To date, high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) is the primary method in detecting PFAAs in complex samples [31,32]. However, such methods require complicated, and laborious sample preparation procedures.…”

Ultra‐low current electrospray ionization of chloroform solution for the analysis of perfluorinated sulfonic acids

“…It is worth noting that the extraction solvent was not systematically optimized in this work. Other fluorinated nonpolar solvents48 and a dispersive liquid-liquid microextraction strategy[48][49][50] would provide improved extraction performances, particularly for the more complicated samples such as wastewater and urine. A more comprehensive study on the low current ionization phenomenon of nonpolar solvents could enable the direct analysis of these extracts.Single-blind experiments were designed to verify the precision and accuracy of our method.…”