Assessment of paraoxonase 1 activity and malondialdehyde levels in patients with rheumatoid arthritis

Başkol, Gülden; Demir, Hüseyin; Başkol, Mevlüt; Kilic, Eser; Ateş, Filiz; Koçer, Derya; Muhtaroğlu, Sabahattin

doi:10.1016/j.clinbiochem.2005.06.010

Cited by 80 publications

(70 citation statements)

References 37 publications

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“…We used the substances reacting with thiobarbituric acid measured in plasma at 535nm (Brown & Kelly, 1996). Clinical studies have shown increased plasmatic levels of MDA in patients with RA (Baskol et al, 2005(Baskol et al, , 2006Sarban et al, 2005). The level of MDA in the plasma of arthritic animals was also elevated (Bauerova et al, 2008bHe et al, 2006;Sotnikova et al, 2009;Strosova et al, 2008Strosova et al, , 2009Tastekin et al, 2007).…”

Section: Adjuvant Arthritis: An Animal Model For Preclinical Evaluatimentioning

confidence: 99%

Modern Pharmacological Approaches to Therapies: Substances Tested in Animal Models of Rheumatoid Arthritis

Bauerová¹,

Poništ²,

Nosáľ³

et al. 2012

Rheumatoid Arthritis - Treatment

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Section: Adjuvant Arthritis: An Animal Model For Preclinical Evaluatimentioning

confidence: 99%

Modern Pharmacological Approaches to Therapies: Substances Tested in Animal Models of Rheumatoid Arthritis

Bauerová¹,

Poništ²,

Nosáľ³

et al. 2012

Rheumatoid Arthritis - Treatment

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“…PON1 catalyzes the breakdown of organophosphates (Jakubowski, 2000;Josse et al, 2001) and also hydrolyzes homocysteine thio-lactone, which can harm some proteins by homocysteinylation. Reduced PON1 activities have been reported in cardiovascular diseases (McElveen et al, 1986;Navab et al, 1997), diabetes mellitus (Abbott et al, 1995;Mackness et al, 1998;Sakai et al, 1998), chronic renal failure (Dantoine et al, 1998), rheumatoid arthritis (Baskol et al, 2005), hyperthyroidism (Raiszadeh et al, 2004), age-related macular degeneration (Baskol et al, 2006) and in cataract (Hashim and Zarina, 2007).…”

Section: Introductionmentioning

confidence: 99%

Comparative efficacy of captopril and allylmercaptocaptopril in the maintenance of oxidative-antioxidative equilibrium and attenuation of selenite-induced cataract in rats

Lakshmi¹,

Sharma²

2011

International Journal of Biological and Chemical Sciences

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The present study was undertaken to investigate the comparative efficacy of captopril (CP) and allylmercaptocaptopril (AMC) supplementation following selenite exposure with respect to oxidant-antioxidant equilibrium and prevents cataract formation in rat pups. Forty Wistar-albino rat pups were equally divided into 4 groups. In Group I; only subcutaneous (s.c) saline was injected. In Group II; single dose of sodium selenite (19 µM/kg body weight, s.c) was injected on postpartum day 10. One day before the selenite challenge, the pups in Group III and IV were injected intraperitoneally a single dose of 50 mg/kg of CP and AMC respectively and repeated once daily thereafter up to 21 st day. The development of cataract was assessed weekly. The density of cataract was graded by slit-lamp biomicroscopy. On day 21, the blood was collected and lenses were removed. Total oxidant status (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI) and malondialdehyde (MDA) level were determined in the lenses of the rat pups. Serum paraoxonase-1 (PON1) activity was determined. All of the lenses of rat pups in Group I remained clean. All rat pups developed dense nuclear opacity in Group II. Three out of 10 rat pups developed slight nuclear opacity in Group III while only one rat pup out of 10 in Group IV had vacuolization but not opacity. Differences among the groups were statistically significant (p<0.01). Group II lenses had higher mean OSI and MDA level than those of Group III and IV (p<0.01). Group II lenses had lower mean TAC level and serum PON1 activity than those of Group III and IV (p<0.01). A negative correlation was found between serum PON1 activity and lens MDA level (r = -0.6861; P<0.001). CP and AMC both diminished the incidence of cataract due to its protection of the antioxidant defense system but AMC was found to be more effective than CP.

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“…Başkol ve ark. (15) tarafından yapılan bir çalışmada, osteoporotik grupta PON aktivitesinde anlamlı bir düşüş tespit edilmiştir. PON aktivitesindeki azalmayı lipid peroksidasyonu ve serbest radikallerin artışına bağlamışlardır.…”

Section: Discussionunclassified

The Investigation of Impact of Stronsium Ranelat Application on Paraoxonase and Arylesterase Activities in Liver, Kidney and Muscle Tissues in Experimental Osteoporosis Rat Model

Berköz¹,

Sağır²,

Yalın³

et al. 2017

Van Med J

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ÖZET Amaç: Yaptığımız bu çalışmada deneysel osteoporoz modeli oluşturulan sıçanlarda, post-menopozal tedavide yaygın olarak kullanılan stronsiyum ranelatın karaciğer, böbrek ve kas dokularındaki paraoksonaz (PON) ve arilesteraz (ARE) enzim aktiviteleri üzerindeki etkisi araştırılmıştır. Gereç ve Yöntem:Bu çalışmada 35 adet dişi Wistar Albino sıçan kullanılmış ve her bir grupta 7 hayvan olacak şekilde 5 gruba ayrılmıştır. Bu gruplar kontrol grubu (Grup I), 3 ay boyunca sadece stronsiyum ranelat uygulanan grup (Grup II), sadece ooferektomi uygulanan grup (Grup III), ooferektomi sonra profilaktik amaçla hemen stronsiyum ranelat tedavisine başlanan grup (Grup IV) ve ooferektomi yapıldıktan 3 ay sonra stronsiyum ranelat tedavisine başlanan grup (Grup V) olarak belirlenmiştir. Tüm gruplardaki hayvanların karaciğer, böbrek ve kas dokuları izole edilerek PON ve ARE aktivitelerine bakılmıştır. PON ve ARE değerleri bakımından gruplar arasındaki istatistiksel farklılıklar ANOVA ve alt grup karşılaştırmalarında Tukey çoklu karşılaştırma testleri kullanılarak değerlendirilmiştir. Bulgular: Yaptığımız çalışmada tüm grupların karaciğer, böbrek ve kas PON ve ARE aktiviteleri kontrol grubuna kıyasla anlamlı ölçüde düşük olduğu tespit edilmiştir (p<0,05). Ayrıca Grup V'in karaciğer PON ve ARE aktivitelerinin Grup II, Grup III ve Grup IV'e göre anlamlı ölçüde yüksek olduğu tespit edilmiştir (p<0,05). Sonuç:Bulunan sonuçlar postmenopozal dönemin ve stronsiyum ranelat kullanımının karaciğer, böbrek ve kas dokularındaki PON ve ARE aktivitelerini azalttığını, dolayısıyla antioksidan sistemi zayıflattığını göstermektedir.Anahtar Kelimeler: Stronsiyum ranelat, ooferektomi, paraoksonaz, arilesteraz ABSTRACT Objective: In this study, we investigated the effect of stronsium ranelat, which is used extensively in the postmenopausal treatment, on paraoxonase and arylesterase in liver, kidney and muscle tissues of experimental osteoporosis rats. Materials and Methods:35 female Wistar Albino female rats were divided into 5 groups (7 animals in each group). Group I was the control group, Group II received only stronsium ranelat, Group III underwent only oophorectomy, Group IV was consisted of rats in which stronsium ranelat treatment was started just after oophorectomy, and Group V consisted of rats in which stronsium ranelat treatment was started 3 months after oophorectomy. Liver, kidney, and muscle tissues of rats belonging to all groups were isolated and then PON and ARE activities were examined. The statistical differences in terms of PON and ARE values were evaluated by using ANOVA and Turkey Multiple Comparison for subgroups.Results: According to results obtained from this study, a statistically significant decrease in PON and ARE activities of liver, kidney and muscle of rats in all groups was determined compared to control group (p<0.05). Furthermore, a statistically significant decrease in PON and ARE activities was detected in Group V compared to Group II, Group III and Group IV (p<0.05). Conclusion:It can be concluded from this study...

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Assessment of paraoxonase 1 activity and malondialdehyde levels in patients with rheumatoid arthritis

Cited by 80 publications

References 37 publications

Modern Pharmacological Approaches to Therapies: Substances Tested in Animal Models of Rheumatoid Arthritis

Modern Pharmacological Approaches to Therapies: Substances Tested in Animal Models of Rheumatoid Arthritis

Comparative efficacy of captopril and allylmercaptocaptopril in the maintenance of oxidative-antioxidative equilibrium and attenuation of selenite-induced cataract in rats

The Investigation of Impact of Stronsium Ranelat Application on Paraoxonase and Arylesterase Activities in Liver, Kidney and Muscle Tissues in Experimental Osteoporosis Rat Model

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