Assessment of oral solid dosage forms administration manner and acceptability

Abstract

Taking oral solid dosage forms (OSDFs) safely and effectively is particularly important. This study aimed to determine the pattern and knowledge about the proper criteria of OSDF administration and the consumers’ preferences toward OSDF characteristics. The aims of this study were achieved by cross-sectional survey through open and closed-ended questionnaires, and the presence of the main OSDF administration recommendations of a sample of 32 OSDF drug leaflets was assessed. Based on a simple random sample of 250 volunteers, we found inadequate compliance with the OSDF medicine administration criteria. We also found an absence of the main recommendations of OSDF drug administration on most of the investigated OSDF drug leaflets. Conventional white, round tablets were found to be the most preferred type of OSDF drug. These findings can be valuable to pharmaceutical manufacturers, regulatory agencies, and pharmacists to enhancing patient awareness and compliance with OSDF administration for safe and effective drug administration.

Patients’ Preference for Pharmaceutical Dosage Forms: Does It Affect Medication Adherence? A Cross-Sectional Study in Community Pharmacies

“…Numerous studies have indicated that one of the most prevalent reasons people prefer a white color is the perception that a white formulation contains no additional additives. 2 Our results regarding preferred shape and color matched those of a study done in the UK, Saudi Arabia, and Jordan, which indicated that small, round shapes were preferred, as were pink or white as colors. 21 However, our finding was contrary to a study finding in the UK, which demonstrated that small, round tablets have a negative effect at every stage of life and are least accepted by older people and their careers.…”

“…Liquid DF is mainly classified into two categories: internal and external liquid preparations. 2,3 Semisolid DF is subcategorized as ointments, creams, pastes, and jellies. 3,4 There are various solid DF, including tablets, capsules, pills, etc.…”

Effects of Beverage Solvents on Disintegration Time and Dissolution Rate of Metronidazole Tablets

“…OSDFs are not without some shortcomings; however, the advantages outweigh their shortcomings. These advantages include selfadministration, dose accuracy, compactness, ease of manufacture, and long shelf life (Avbunudiogba et al, 2013;Almukainzi et al, 2018;Almukainzi et al, 2021). The disintegration rate, dissolution rate, and invariably the bioavailability of OSDF depend on many factors, one of which is the physiological state of the gastrointestinal tract (GIT).…”

“…The ease of AVBUNUDIOGBA, J. A; OKAFO, S. E; ALALOR, C. A; AVBUNUDIOGBA, R. E; CHRISTOPHER, V. O disintegration and dissolution of OSDF into the gastric environment is an important factor in drug bioavailability (Almukainzi et al, 2021). For a drug to be absorbed from the GIT, it must first of all be in solution.…”

“…Tablets/capsules ought to be administered with a full glass of water; however, it has been observed that many patients do not follow this recommendation. Many patients take their medications with liquid beverages other than water (Almukainzi et al, 2021). Thus, the aim of the present study is to assess the effect of commonly consumed beverages on the disintegration and dissolution of metronidazole tablets.…”