Assessment of Nano Cellulose from Peach Palm Residue as Potential Food Additive: Part II: Preliminary Studies

Abstract

High consumption of dietary fibers in the diet is related to the reduction of the risk of non-transmitting of chronic diseases, prevention of the constipation etc. Rich diets in dietary fibers promote beneficial effects for the metabolism. Considering the above and recognizing the multifaceted advantages of nano materials, there have been many attempts in recent times to use the nano materials in the food sector including as food additive. However, whenever new product for human and animal consumption is developed, it has to be tested for their effectiveness regarding improvement in the health of consumers, safety aspects and side effects. However, before it is tried with human beings, normally such materials would be assessed through biological tests on a living organism to understand its effect on health condition of the consumer. Accordingly, based on the authors' finding reported in a previous paper, this paper presents body weight, biochemical (glucose, cholesterol and lipid profile in blood, analysis of feces) and histological tests carried out with biomass based cellulose nano fibrils prepared by the authors for its possible use as food additive. Preliminary results of the study with mice have clearly brought out potential of these fibers for the said purpose.

The Evaluation of Drug Delivery Nanocarrier Development and Pharmacological Briefing for Metabolic-Associated Fatty Liver Disease (MAFLD): An Update

“…These polymers were reported to have a lowering influence of cholesterol, low-density lipoproteins (LDL)-cholesterol fraction, hyperlipidemia, cholesterol and lipid levels, respectively. Additionally, there is a need to investigate glucose-lowering polymer synergetic effects, such as cellulose, which positively impacts diabetes mellitus type 2 [ 87 , 88 , 89 ], and inulin, which was reported to reduced serum insulin levels but simultaneously increased body weight in diabetic rats [ 90 ]. Thus, preliminary studies are recommended when exploring glucose-polymers as excipients for nanoparticles, such as dextrans, icodextrin, and amylose, to ensure that there are no short-term or long-term consequences on MAFLD patients, including the blood glucose levels [ 91 , 92 , 93 , 94 ].…”

Lignocellulosic Biomass for the Synthesis of Nanocellulose and Its Eco-Friendly Advanced Applications

“…It can be used in the reduction of risk of chronic diseases like diabetes and cardiacarrest. Additionally, it improved physiological effects, including laxation and blood sugar level (Andrade et al, 2015). Nanocellulose-based film has extraordinary properties of air and oxygen barriers, which protect the food from undesirable entities.…”

Assessment of the Gastrointestinal Fate of Bacterial Cellulose and Its Toxicological Effects After Repeated-dose Oral Administration

“…A few recent studies addressed already the safety aspects of nanocelluloses [16][17][18][19][20][21]. Mackie et al [17] studied the gastrointestinal fate of cotton cellulose nano-crystals (CNCs) as Pickering stabilization agents in oil in water emulsions.…”

“…However, regulatory authorizations for their use in food are still missing, given that nano-scale materials often exhibit different properties and interactions with biological systems than those of their micro-sized counterparts [12][13][14][15]. Thus, investigating the toxicology of ingested nanomaterials, in particular nanocelluloses, is of great importance, when considering their market applications.A few recent studies addressed already the safety aspects of nanocelluloses [16][17][18][19][20][21]. Mackie et al [17] studied the gastrointestinal fate of cotton cellulose nano-crystals (CNCs) as Pickering stabilization agents in oil in water emulsions.…”