Assessment of myocardial repolarisation parameters in patients with familial Mediterranean fever

Karaman, Kayıhan; Karayakalı, Metin; Erken, Ertuğrul; Demirtaş, Ahmet; Öztürk, Mustafa; Altunkaş, Fatih; Arif, Ambreen; Turan, Oğuzhan Ekrem; Ceyhan, Köksal; Çelik, Ataç

doi:10.5830/cvja-2016-074

Cited by 6 publications

(4 citation statements)

References 37 publications

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“…[40,41] Studies with adult patients have shown that the Tp-e interval and corrected Tp-e/QT ratio is statistically and significantly prolonged compared to healthy controls in FMF. [14,15] In our study, we observed that the QT and Tp-e intervals displaying ventricular repolarization in the FMF group were significantly more prolonged than in the control group.…”

Section: Discussionmentioning

confidence: 47%

“…It is thought that transmission problems and rhythm disorders are associated with continued inflammationrelated ischemia and/or local fibrosis in FMF. [15,34] The myocardial repolarization QT duration, QT dispersion and transmural repolarization can be calculated and evaluated. [35][36][37] While the peak point of the T wave on the electrocardiography signifies the end of the epicardial action potential and the earliest completed repolarization on the ventricular wall, the end of the T wave corresponds to the end of the mid myocardial action potential; this distance is thought to indicate total repolarization.…”

Section: Discussionmentioning

confidence: 99%

“…[12,13] There are many studies in the literature which have used these new indices that indicate ventricular repolarization in FMF. [4,5,[14][15][16] Studies have revealed that the Tp-e interval is superior to QT dispersion in foreseeing sudden cardiac death and ventricular arrhythmia. [17] Our aim in this study was to evaluate the longstanding as well as the newly developed electrocardiogram parameters indicating myocardial repolarization and to assess the QT interval, corrected QT interval, Tp-e interval, corrected Tp-e, Tp-e/corrected QT, P wave dispersion to see whether pediatric patients diagnosed with FMF have a predisposition toward arrhythmia.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Cardiac Arrhythmia Susceptibility in Pediatric Familial Mediterranean Fever Patients

Güngörer

Sert

Arslan³

2023

Journal of Contemporary Medicine

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Aim: Familial Mediterranean fever is an autoinflammatory disease characterized by attacks of inflammation. Despite treatment, there is evidence of subclinical persistence of inflammation with normal laboratory values. This study was conducted to investigate the cardiac effects of continued subclinical inflammation in children and the predisposition towards arrhythmia in familial Mediterranean fever. Materials and Methods: Age and sex-matched familial Mediterranean fever patients and healthy controls were compared in terms of demographic, laboratory, echocardiographic and electrocardiographic data. The patients with familial Mediterranean fever were grouped according to disease severity scores and compared in terms of electrocardiographic data that could indicate arrhythmogenesis. Correlation analysis was used to examine the relationship between the electrocardiographic measurements and the clinical and laboratory data. Results: In the comparison of the two groups, no significant difference was found in the echocardiographic measurements in terms of left ventricular systolic and diastolic functions. According to these data, QT and Tp-e intervals were significantly longer in those with familial Mediterranean fever (p=0.002, p=0.046, respectively). When the patients were classified according to the 3 separate disease severity scores, QT dispersion in the moderate-severe disease group was significantly longer than in the mild disease group (p

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Section: Discussionmentioning

confidence: 47%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of Cardiac Arrhythmia Susceptibility in Pediatric Familial Mediterranean Fever Patients

Güngörer

Sert

Arslan³

2023

Journal of Contemporary Medicine

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“…QTc (corrected), Q-Tpeak (QTp), Tpeak-Tend (Tp-Te), and Tp-Te/QT have been defined as predictors of risk for VA or SCD in various clinical scenarios like in HF patients, Brugada syndrome, hypertrophic cardiomyopathy, Long-QT syndrome and bradyarrhythmia or general population [8], [9], [10], [11], [12], [13]. The Tp-Tec interval and Tp-Tec/QT ratio were also found to be more accurate measurements of the TDR or DVR compared to the QT, QTd (QTdispersion), and Tp-Te interval [14]. Different cutoff values for Tp-Te interval have been proposed or found in previous studies [8], [15].…”

Section: Introductionmentioning

confidence: 99%

A Comparing of Tp-Te Interval and Tp-Te/Qt Ratio in Patients with Preserved, Mid-Range and Reduced Ejection Fraction Heart Failure

Son¹,

Boduroğlu²

2019

Open Access Maced J Med Sci

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BACKGROUND: Heart failure (HF) is classified in three class: HF with preserved EF (HFpEF); normal or LVEF ≥ 50%, HF with reduced EF (HFrEF); LEVF < 40% and newly HF mid-range EF (HFmrEF); LVEF 40-49%. On Electrocardiography (ECG) T wave, Tpeak-Tend (Tp-Te) interval reflects transmural dispersion of repolarisation (TDR) which of these indexes have been proposed as predictors of risk for ventricular arrhythmia (VA) in many cardiac diseases. AIM: Aim of this study to asses these indices of TDR among three HF class. METHODS: Total of 192 patients were included in this study. RESULTS: Many of indices like Tp-Te, Tp-Te/QT wasn’t different between groups (P > 0.05). But mean Q-Tpeak (QTp), S-Tend (S-Te) and S-Tpeak (S-Tp) were found significantly different between groups (P < 0.05). Again S-Te was found different according to having fragmented QRS (fQRS) on ECG (P = 0.031). Comparing to mitral inflow E/A parameters showed significant differences for Tp-Te, Tp-Tec, Tp-Te/QT, Tp-Te/QTc and Tp-Tec/QTc parameters. Finally, we found correlations between S-Te and white blood cell (WBC) (r = - 0.171; P = 0.037) and S-Tp and WBC (r = - 0.170; P = 0.038) and between S-Te and fQRS (r = 0.158; P = 0.031). CONCLUSIONS: We didn’t find differences for many of indices of TDR like Tp-Te interval between groups except QTp, S-Te, S-Tp intervals. Also, S-Te and fQRS showed significant correlation. For prediction of ventricular arrhythmia and cardiovascular death newer indexes on ECG are needed to be established in the future which will make us facilitate to distinguish high risk patients.

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Cardiac disease in familial Mediterranean fever

Erken

2017

Rheumatol Int

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Familial Mediterranean fever (FMF) is an autoinflammatory disease manifested by inflammatory attacks of peritonitis, pleuritis, pericarditis accompanied by fever and arthritis. Mutations of MEFV gene results in pyrin dysfunction, which causes uncontrolled interleukin-1 beta production and triggers the inflammatory attacks. Inflammation persists even during attack-free periods in one-third of the FMF patients. Findings of elevated proinflammatory cytokine patterns during remission as well as inflammatory attacks indicate the continuous subclinical disease activity and inflammation. Chronic inflammation was thought to be related to the cardiovascular risk in FMF patients. Main cardiac manifestations reported in FMF are pericarditis, idiopathic recurrent pericarditis, pericardiac tamponade, coronary heart disease and abnormal cardiovascular reactivity. Cardiac involvement in FMF may often be related to secondary AA amyloidosis. Deposition of amyloid may lead to cardiovascular morbidity and mortality in FMF patients. Associations of several vasculitic disorders such as Immunoglobulin A-associated vasculitis, polyarteritis nodosa and Behcet's disease are common in FMF. Appropriate prophylactic treatment with colchicine is recommended to prevent from cardiovascular risks. For those resistant to colchicine, IL-1 inhibitor agents can be used. Associated vasculitis should be treated with immunosuppressive agents. This review article aims to compile information about cardiac disease in FMF and refer to recent studies on the topic.

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Assessment of myocardial repolarisation parameters in patients with familial Mediterranean fever

Cited by 6 publications

References 37 publications

Evaluation of Cardiac Arrhythmia Susceptibility in Pediatric Familial Mediterranean Fever Patients

Evaluation of Cardiac Arrhythmia Susceptibility in Pediatric Familial Mediterranean Fever Patients

A Comparing of Tp-Te Interval and Tp-Te/Qt Ratio in Patients with Preserved, Mid-Range and Reduced Ejection Fraction Heart Failure

Cardiac disease in familial Mediterranean fever

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