Assessment of mucociliary clearance as an indicator of nasal function in patients with COVID-19: a cross-sectional study

Koparal, Mehtap; Kurt, Ercan; Altuntaş, Emine Elif; Doğan, Fatih

doi:10.1007/s00405-020-06457-y

Cited by 36 publications

(28 citation statements)

References 28 publications

(37 reference statements)

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“…In the literature, similar to our study, mucociliary clearance function and sinonasal complaints were evaluated in pathologies that directly affect the nasal mucosa, such as acute rhinitis and chronic rhinosinusitis. More significant changes were found in these studies compared to those obtained in our study [29,30]. This suggests that increases in MCT, nasal blockage and postnasal discharge complaints detected in the N95 mask group and the increase in nasal blockage complaint seen in the surgical mask group were mild.…”

Section: Discussionsupporting

confidence: 45%

The effect of N95 and surgical masks on mucociliary clearance function and sinonasal complaints

Cengiz

Can

2021

Eur Arch Otorhinolaryngol

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Purpose The aim of this study was to reveal the effect of N95 and surgical masks on mucociliary clearance function and sinonasal complaints. Methods Sixty participants were enrolled in this study, including 30 people in N95 mask group and 30 people in surgical mask group. Two interviews, three days apart, were performed with all participants. The participants were asked not to use any mask before the first interview while they were asked to use the determined mask just before the second interview for 8 h. In both interviews, the mucociliary clearance times (MCTs) were measured and participants were asked to score ten distinct sinonasal complaints using visual analog scale (VAS). Data obtained from first interview were named pre-mask data, data obtained from second interview were called after-mask data. In both groups, pre-mask MCTs and VAS scores were compared with after-mask MCTs and VAS scores. Results After-mask MCTs (mean = 13.03 ± 6.05 min) were significantly longer than pre-mask MCTs (mean = 10.19 ± 4.21 min) in N95 mask group ( p = 0.002). No significant difference was found between after-mask and pre-mask MCTs (mean = 12.05 ± 5.21 min, mean = 11.00 ± 5.44 min, respectively) in surgical mask group ( p = 0.234). When after-mask VAS scores were compared with pre-mask VAS scores, it was found that N95 mask use increased nasal blockage and postnasal discharge, surgical mask usage increased nasal blockage. Conclusion While the use of N95 mask leads to nasal blockage and postnasal discharge, surgical mask use results in nasal blockage. N95 masks cause impairment in mucociliary clearance function. But all these effects are mild. Surgical masks have not been found to have any effect on mucociliary clearance function.

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Section: Discussionsupporting

confidence: 45%

The effect of N95 and surgical masks on mucociliary clearance function and sinonasal complaints

Cengiz

Can

2021

Eur Arch Otorhinolaryngol

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“…Nasal mucociliary clearance time was prolonged in hospitalized COVID-19 patients without chemosensory deficits than in healthy otolaryngology outpatients with non-nasal symptoms (Koparal et al ( 2020 )). Impaired mucociliary clearance may promote SARS-CoV-2 spread into the deeper lung parenchyma (Robinot et al 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Is loss of smell an early predictor of COVID-19 severity: a systematic review and meta-analysis

et al. 2021

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“…Keeping this in view, on reviewing the existing literature on COVID-19, it has been observed that nasal mucociliary clearance was profoundly delayed throughout the course of infection and may persist even after [ 15 , 16 ]. The nasal mucociliary clearance is the primary innate defense mechanism of the paranasal sinus against various pathogens.…”

Section: Is Viral-induced Immune System Dysfunction the Cause For Mucormycosis?mentioning

confidence: 99%

Current Understanding in the Pathophysiology of SARS-CoV-2-Associated Rhino-Orbito-Cerebral Mucormycosis: A Comprehensive Review

Jose¹,

Singh²,

Roychoudhury

et al. 2021

J. Maxillofac. Oral Surg.

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Aim Recently, with the second wave of COVID-19, the Indian subcontinent has witnessed a dramatic rise in mucormycosis infection in patients recovered from COVID-19. This association has been documented in various case reports/case series and institutional experiences, and the mortality associated with this fungal infection is emerging as a cause of concern. The aim of the present paper is to provide a scientific overview on the pathogenesis of mucormycosis in COVID-19 beyond the conventional understanding of the disease process, which may not otherwise explain the increased incidence of mucormycosis in SARS-CoV-2. Methodology This paper is structured as a narrative review of the published literature on the pathogenesis of COVID-19 which contributes to the development of mucormycosis. Apart from the acknowledged role of ketoacidosis, high blood sugar, and iron metabolism in the pathogenesis of mucormycosis, other factors involved in pathophysiology of COVID-19 which might alter or enhance the mucormycosis infection such as (1) the role of ferritin, (2) high serum iron, (3) free radical-induced endothelitis, (4) hepcidin activation, (5) upregulation of glucose receptor protein (GRP78) are discussed in the pathophysiology of COVID-19-associated mucormycosis. Conclusion A new proposal for the pathogenesis based on the ferritin, viral mimicry of hepcidin and GRP78–CotH3 interaction, which clearly explains the surge in mucormycosis in SARS-CoV-2 infection, has been explained.

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Assessment of mucociliary clearance as an indicator of nasal function in patients with COVID-19: a cross-sectional study

Cited by 36 publications

References 28 publications

The effect of N95 and surgical masks on mucociliary clearance function and sinonasal complaints

The effect of N95 and surgical masks on mucociliary clearance function and sinonasal complaints

Is loss of smell an early predictor of COVID-19 severity: a systematic review and meta-analysis

Current Understanding in the Pathophysiology of SARS-CoV-2-Associated Rhino-Orbito-Cerebral Mucormycosis: A Comprehensive Review

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