Assessment of Morus alba (Mulberry) leaves extract for anti-convulsant property in rats

Abstract

Background: The mulberry tree, a plant of the family Moraceae and the genus Morus, has been widely cultivated to feed silkworms. Various parts of Morus alba linn used as an Anti-inflammatory, hypoglycemic, cardioprotective, hepatoprotective, free radical scavenging activity and neuroprotective agent. The plant contains flavonoids, moranoline, albanol, morusin coumarine, and stilbene, which have. In this study, anticonvulsant property of Morus alba leaves extract (MAE) was evaluated by using MES and PTZ induced convulsion in rats.Methods: Effects of MAE were evaluated in experimental models of electro convulsions, maximal electro shock (MES) and chemoconvulsion induced by pentylenetetrazole (PTZ) in rats (n=6), which were treated intraperitonially with doses of 100, 200 and 400mg/kg.Results: The duration of tonic hind limb extension (seconds) with MAE in MES induced convulsions at dose of 100, 200, 400 mg/kg is 8.33±1.21, 6.83±1.16 & 3.16±0.98 respectively. In the dose of 400 mg/kg of MAE showed highly significant results by reducing the duration of tonic hind limb extension in MES induced convulsions. And onset of jerky movements (seconds) with MAE in PTZ induced convulsions at dose of 100, 200, 400mg/kg is 157.83±8.99, 195.66±17.02 and 295.50±21.10 respectively. In the dose of 400mg/kg of MAE showed highly significant results by delaying the onset of convulsions.Conclusions: Results indicate that the MAE have anticonvulsant effects in MES induced convulsions and in PTZ induced convulsions.

Morus alba L. Plant: Bioactive Compounds and Potential as a Functional Food Ingredient

“…These concentrations also significantly reduced the maximal electroshock-induced tonic hindlimb extension [ 75 ]. Meanwhile, M. alba leaves’ significant antiepileptic activity at 200 and 400 mg/kg at 6.8 and 3.16 s, respectively, was observed by Rayam et al [ 76 ].…”

“…According to Gupta et al [ 75 ] and Rayam et al [ 76 ], M. alba leaves could facilitate gamma-aminobutyric acid (GABA) transmission, thus exhibiting an anticonvulsant ability in rats [ 77 ]. A 25 mg/kg methanolic leaf extract actually postponed the onset of pentylenetetrazole (PTZ)-induced chronic seizure.…”

Morus alba (The Mulberry Fruit): Budding and unrecognised potential

“…These concentrations also significantly reduced maximal electroshock-induced tonic hindlimb extension (Gupta et al, 2018). Meanwhile, M. alba leaves significant antiepileptic activity at 200 and 400 mg/kg at 6.8 and 3.16 s, respectively, as reported by (Rayam et al, 2019) was observed. In the context of Alzheimer's disease, 28-day administration of 100 mg/kg ethanolic leaves improved M. alba both learning and memory function in spatially-impaired rats, while the 200 mg/kg and 400-mg/kg mg/kg extracts inhibited the effect on memory disorders (Tamtaji et al, 2016).…”

“…According to (Gupta et al, 2018) and (Rayam et al, 2019), M. alba leaves could facilitate the transfer of gamma-aminobutyric acid (GABA) and thus show an antispasmodic effect in rats (Diniz et al, 2015). A 25 mg/kg methanolic leaf extract actually delayed the onset of pentylenetetrazole (PTZ)-induced chronic seizures.…”

Assessment of Morus alba (mulberry) leaves extract for anti-psychotic effect in rats

“…12 M. alba leaves extract showed anticonvulsant effects in MES induced convulsions and in PTZ induced convulsions. 13 A piperidine alkaloid and some glycoproteins were isolated from the bark and leaves, which had antidiabetic effects. 14 Taking this into consideration the reported psychopharmacological effects of morus alba leaves in various animal models, ignited a spirit to evaluate antipsychotic effects of M. alba leaves extract by haloperidol induced catalepsy model in rats.…”