Assessment of Milling-Induced Disorder of Two Pharmaceutical Compounds

Otte, Andrew; Carvajal, Micaela

doi:10.1002/jps.22415

Cited by 54 publications

(18 citation statements)

References 27 publications

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“…3), compromising a positive effect, reducing the active surface and bringing down bioavailability of essential nutrients of the treated product. Similar results were received by other authors as well [25].…”

Section: Discussion Of Results Of Optimization Of the Bee Pollen Shresupporting

confidence: 92%

Optimization of technology for shredding the bee pollen

Merzlov

Lomova

Narizhniy

et al. 2017

EEJET

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Section: Discussion Of Results Of Optimization Of the Bee Pollen Shresupporting

confidence: 92%

Optimization of technology for shredding the bee pollen

Merzlov

Lomova

Narizhniy

et al. 2017

EEJET

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“…Otte and Caravajal employed a combination of particle size, surface area, IGC, DSC and PXRD to examine the surface disorder and bulk properties of ketoconazole and griseofulvin as a function of cryomilling time 50) . A reduction in surface cr ystallinity and an increase in γ d S V and ∆G 0 AB were obser ved for both compounds upon cryomilling.…”

Section: Amorphous Solids and Glass Transitionmentioning

confidence: 99%

A Review of Inverse Gas Chromatography and its Development as a Tool to Characterize Anisotropic Surface Properties of Pharmaceutical Solids

Heng

2013

KONA

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Surface properties can profoundly impact the bulk and interfacial behavior of pharmaceutical solids, and also their manufacturability, processability in drug product processes, dissolution kinetics and mechanism in drug delivery. Variation in the inter-and intra-molecular interactions gives rise to anisotropic surface properties of crystalline solids which display direction-dependent characteristics relative to the orientation of the crystal unit structure. Despite its establishment since the 1950s, inverse gas chromatography (IGC) is still an evolving technology in the field of pharmaceutical R&D. In this review, the principles behind IGC as a physicochemical technique to measure the surface properties of solids are presented. The introduction is followed by an overview of its utility in pharmaceutical R&D, spanning a variety of applications including batch-to-batch variability, solid-solid transitions, physical stability, interfacial behavior in powder processing, and more. For anisotropic materials, IGC has been utilized to characterize the heterogeneity of materials using adsorption and energy distribution functions. Recent development and applications of IGC at finite concentration (IGC-FC) to determine the surface heterogeneity distribution of solids are presented. This methodology overcomes a number of limitations associated with traditional experiments.

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“…drying, crystallisation, roller compaction, spray drying, milling, blending, etc.) on particle bulk and surface properties, has attracted much research interests over the past two decades Dujardin et al, 2012;Iyer et al, 2013;Otte et al, 2011;Yamauchi et al, 2011;Meier et al, 2009). Milling is one the most common particle size reduction step.…”

Section: Introductionmentioning

confidence: 99%

Effect of milling temperatures on surface area, surface energy and cohesion of pharmaceutical powders

Shah

Wang

Olusanmi

et al. 2015

International Journal of Pharmaceutics

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Particle bulk and surface properties are influenced by the powder processing routes. This study demonstrates the effect of milling temperatures on the particle surface properties, particularly surface energy and surface area, and ultimately on powder cohesion. An active pharmaceutical ingredient (API) of industrial relevance (brivanib alaninate, BA) was used to demonstrate the effect of two different, but most commonly used milling temperatures (cryogenic vs. ambient). The surface energy of powders milled at both cryogenic and room temperatures increased with increasing milling cycles. The increase in surface energy could be related to the generation of surface amorphous regions. Cohesion for both cryogenic and room temperature milled powders was measured and found to increase with increasing milling cycles. For cryogenic milling, BA had a surface area ∼ 5× higher than the one obtained at room temperature. This was due to the brittle nature of this compound at cryogenic temperature. By decoupling average contributions of surface area and surface energy on cohesion by salinization post-milling, the average contribution of surface energy on cohesion for powders milled at room temperature was 83% and 55% at cryogenic temperature.

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Assessment of Milling-Induced Disorder of Two Pharmaceutical Compounds

Cited by 54 publications

References 27 publications

Optimization of technology for shredding the bee pollen

Optimization of technology for shredding the bee pollen

A Review of Inverse Gas Chromatography and its Development as a Tool to Characterize Anisotropic Surface Properties of Pharmaceutical Solids

Effect of milling temperatures on surface area, surface energy and cohesion of pharmaceutical powders

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