Assessment of liver and cardiac iron overload using MRI in patients with chronic anemias in Latin American countries: results from ASIMILA study

Cançado, Rodolfo Delfini; Watman, Nora; Lobo, Clarisse; Chona, Zulay; Manzur, Fernando; Traina, Fabı́ola; Park, Miriam; Drelichman, Guillermo; Zarate, Juan Pablo; Marfil, L J

doi:10.1080/10245332.2018.1461292

Cited by 12 publications

(7 citation statements)

References 16 publications

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“…Previous literature shows a moderate correlation between liver iron concentration and SF in MDS patients [15]. Our study confirms that ASF correlates with liver T2*and cardiac T2*, but there is no significant correlation between cardiac T2* and liver T2*, and the correlation coefficients between ASF and cardiac are significantly higher than those in the liver.…”

Section: Discussionsupporting

confidence: 83%

Analysis of the influencing factors related to liver and cardiac iron overload in MDS patients detected by MRI in the real world

et al. 2021

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Objectives:We aim to explore and analyze the related influencing factors of liver and cardiac iron overload in MDS patients detected by magnetic resonance imaging (MRI). Methods: We have detected cardiac T2* and liver T2* by MRI in 105 MDS patients. Among them, 20 patients accepted MRI examination before and after iron chelation therapy (ICT). Results: We found that adjusted ferritin (ASF) was significantly correlated with liver T2* and cardiac T2*. RBC transfusion volume, brain natriuretic peptide (BNP) and age were the related factors of cardiac T2*, while RBC transfusion volume and erythropoietin (EPO) were related factors of liver T2*. After ICT, the changes of ASF and liver T2* were earlier than cardiac T2*. Chronic hepatitis but virus copy normal's has no significant effect on liver iron deposition. Conclusion: These results showed special attention should be paid to these related influencing factors of liver and cardiac T2* expression when we evaluated iron overload and detected the efficacy of ICT in MDS patients.

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Section: Discussionsupporting

confidence: 83%

Analysis of the influencing factors related to liver and cardiac iron overload in MDS patients detected by MRI in the real world

et al. 2021

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“…In a post-hoc analysis of the EPIC study, patients with AA were seen to have had an average of between 8 and 15 transfusion sessions in the previous year, and their median ferritin levels were 3,600-3,700 ng/ml (73). Using imaging techniques (MRI), IOL was observed in the liver in 76.4% of patients (including AA) and in the heart in 19.2% (74). The presence of an IOL in patients with severe AA reduces the efficacy of the immunosuppressive therapy and increases the risk of a relapse, confirming that it is a negative prognostic factor for the outcome of these patients (75).…”

Section: Utility Of Iron Chelation In Aplastic Anemiamentioning

confidence: 99%

“…The EPIC prospective study evaluated the efficacy and safety of ICT with deferasirox in 116 patients with AA (74). The analysis showed that therapy with deferasirox efficaciously reduced median serum ferritin levels: this efficacy was associated with the transfusional iron load and the dose of deferasirox, with higher doses of medicinal product needed to reduce the iron load in subjects with a high intake (79).…”

Section: Utility Of Iron Chelation In Aplastic Anemiamentioning

confidence: 99%

From Biology to Clinical Practice: Iron Chelation Therapy With Deferasirox

et al. 2021

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Iron chelation therapy (ICT) has become a mainstay in heavily transfused hematological patients, with the aim to reduce iron overload (IOL) and prevent organ damage. This therapeutic approach is already widely used in thalassemic patients and in low-risk Myelodysplastic Syndrome (MDS) patients. More recently, ICT has been proposed for high-risk MDS, especially when an allogeneic bone marrow transplantation has been planned. Furthermore, other hematological and hereditary disorders, characterized by considerable transfusion support to manage anemia, could benefit from this therapy. Meanwhile, data accumulated on how iron toxicity could exacerbate anemia and other clinical comorbidities due to oxidative stress radical oxygen species (ROS) mediated by free iron species. Taking all into consideration, together with the availability of approved oral iron chelators, we envision a larger use of ICT in the near future. The aim of this review is to better identify those non-thalassemic patients who can benefit from ICT and give practical tips for management of this therapeutic strategy.

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“…The liver is the main location for iron storage and is the earliest and most critical organ for iron deposition. 5 Excess accumulation of iron may lead to life-threatening complications, including liver fibrosis, cirrhosis, liver failure, and hepatocellular carcinoma. 6…”

Section: Introductionmentioning

confidence: 99%

“…The liver is the main location for iron storage and is the earliest and most critical organ for iron deposition. 5 Excess accumulation of iron may lead to lifethreatening complications, including liver fibrosis, cirrhosis, liver failure, and hepatocellular carcinoma. 6 The gold standard method to measure liver iron concentration is a biopsy; however, a liver biopsy is invasive and susceptible to sample variability from uneven hepatic iron concentration.…”

Section: Introductionmentioning

confidence: 99%

Abdominal magnetic resonance imaging examination of Tibetan patients with abnormal iron metabolism and a preliminary study of correlations with blood cell analysis

Zhou

et al. 2020

J Int Med Res

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Objective The objective was to investigate factors influencing the high incidence of abnormal iron metabolism in a Tibetan population. Methods This was a retrospective observational study. Magnetic resonance imaging and blood analysis of 363 Tibetan patients were performed and patients divided into normal and abnormal groups based on the clinical diagnostic standard. The upper limit of normal liver iron content was 50 μmol/g. We analyzed the association between abnormal iron metabolism and blood cell indicators using the Spearman rank correlation test. Results In male patients, differences in mean corpuscular hemoglobin (MCH) and MCH concentration in blood between the normal and abnormal groups were significant. Abnormal iron metabolism in male patients was positively correlated with MCH and MCH concentration. In female patients, differences in erythrocytes, hemoglobin, and hematocrit levels between the two groups were significant. Erythrocyte counts and hemoglobin and hematocrit levels of female patients were positively correlated. Conclusion Iron overload in male patients was correlated with an increase in MCH and MCH concentration, and that in female patients was correlated with levels of erythrocytes, hemoglobin, and hematocrit. The incidence rate of iron overload was higher in males than in females and was correlated with age in this Tibetan population.

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Assessment of liver and cardiac iron overload using MRI in patients with chronic anemias in Latin American countries: results from ASIMILA study

Abstract: A high prevalence of iron overload in this patient population in Latin American countries indicates that a better diagnosis and management of iron overload is required in these countries.

Cited by 12 publications

References 16 publications

Analysis of the influencing factors related to liver and cardiac iron overload in MDS patients detected by MRI in the real world

Analysis of the influencing factors related to liver and cardiac iron overload in MDS patients detected by MRI in the real world

From Biology to Clinical Practice: Iron Chelation Therapy With Deferasirox

Abdominal magnetic resonance imaging examination of Tibetan patients with abnormal iron metabolism and a preliminary study of correlations with blood cell analysis

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