Assessment of Lipocalin 2, Clusterin, Soluble Tumor Necrosis Factor Receptor-1, Interleukin-6, Homocysteine, and Uric Acid Levels in Patients with Psoriasis

Ataseven, Arzu; Keşli, Recep; Kurtipek, Gülcan Saylam; Öztürk, Perihan

doi:10.1155/2014/541709

Cited by 40 publications

(44 citation statements)

References 56 publications

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“…No correlation between lipocalin-2 and PASI was reported also by El-Hadidi et al, Kamata et al and Ataseven et al (13,14,20). On the contrary, Romani et al reported a positive correlation between LCN2 and PASI (8).…”

Section: Discussionmentioning

confidence: 80%

“…Our results as well as values of serum lipocalin-2 concentrations are in accordance with few previous studies (8,14,20). Ataseven et al found significantly higher levels of lipocalin-2 in psoriatic patients compared with controls (p < 0.001) (14). The authors suggested that LCN2 could be used as a marker of the disease.…”

Section: Discussionmentioning

confidence: 95%

“…Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a 25 kDa protein built of 178 amino acids and was isolated from human neutrofils in the early 90's (12). It is expressed in liver, lungs, kidneys, stomach, colon and adipocytes, macrophages or epithelial cells (13,14). LCN2 plays a key role in the innate immune response by its bacteriostatic effect through binding to iron-laden bacterial siderophores and thereby inhibiting their proliferation (15).…”

Section: Introductionmentioning

confidence: 99%

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Effect of psoriasis activity and topical treatment on serum lipocalin-2 levels

Baran

Świderska

Myśliwiec

et al. 2016

Journal of Dermatological Treatment

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Effect of psoriasis activity and topical treatment on serum lipocalin-2 levels

Baran

Świderska

Myśliwiec

et al. 2016

Journal of Dermatological Treatment

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“…However, they found a significant correlation between serum uric acid levels and PASI (11). As Ataseven et al mentioned in the limitations of their study, high serum uric acid levels may be related to components of metabolic syndrome (11). Therefore, the effect of metabolic syndrome components should be taken into account when investigating serum uric acid levels.…”

Section: Discussionmentioning

confidence: 90%

Evaluation of serum uric acid levels in psoriasis vulgaris

Yılmaz¹,

Tamer²,

Artüz³

et al. 2017

Turk J Med Sci

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IntroductionPsoriasis is an inflammatory and immune-mediated papulosquamous disease with unknown etiology. It is characterized by abnormal epidermal hyperproliferation and differentiation, and it affects 1%-2% of the population (1).Uric acid is an endogenously produced end-product of adenosine-and guanosine-based purine metabolism (2). A number of studies showed strong correlation among high uric acid levels, insulin resistance, and metabolic syndrome, which has been suggested to develop secondary to insulin resistance (3,4).Few studies in the literature investigated serum uric acid levels in patients with psoriasis, and those studies reported that the levels of uric acid could be correlated with the activity of psoriasis. However, none of those studies evaluated metabolic syndrome, which could directly affect the uric acid level.Psoriasis has been accepted as a systemic disease and it is known to be associated with various disorders such as cardiovascular diseases, hepatosteatosis, obesity, diabetes mellitus, hypertension, and hyperlipidemia. High serum uric acid levels are also associated with components of metabolic syndrome such as obesity, cardiovascular diseases, and hypertension. In our study, we aimed to determine serum uric acid levels in patients with psoriasis and the association of uric acid levels with disease activity by taking the presence of metabolic syndrome into account, since it is one of the most important factors that affect serum uric acid levels. Material and methodsSeventy patients with psoriasis aged between 17 and 82 years who were untreated for psoriasis in the previous 6 months and 70 age-and sex-matched healthy subjects were included in this cross-sectional study. The Scientific Research Assessment Committee of our hospital approved the study protocol and all participants provided written informed consent.The demographic characteristics of the patients such as age and sex, as well as disease characteristics including dermatological examination, type of psoriasis, Background/aim: Psoriasis has been accepted as a systemic disease and it is known to be associated with various disorders including metabolic syndrome. High serum uric acid levels are also associated with the components of metabolic syndrome. In this study, we aimed to determine serum uric acid levels in patients with psoriasis and the association of uric acid levels with disease activity by taking the presence of metabolic syndrome criteria into account, since it is one of the most important factors that affect serum uric acid levels. Materials and methods:In this cross-sectional study, we evaluated 70 psoriasis patients and 70 healthy individuals who were matched with the patients according to the presence of metabolic syndrome. We evaluated the demographic features, levels of serum uric acid, Psoriasis Area Severity Index (PASI) scores, presence of psoriatic arthritis, nail involvement, and metabolic syndrome criteria of the patients.Results: Serum uric acid levels of psoriasis patients were significantly higher than thos...

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“…After the studies made in 1990s where high levels of homocysteine were found in plasma samples of subjects who had or would likely to have a history of myocardial infarction, ischemic stroke or peripheral vascular disease and the association of homocysteine with atherosclerosis and hypercoagulability had been shown [6][7][8][9][10][11][12] , along with increased attention to the comorbidities of psoriasis, as far as we know, 19 studies have been conducted to explore homocysteine levels in these patients. Homocysteine level was found to be high in 12 and normal in 7 of these studies [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] . Since this sulfur-containing amino acid is not taken through diet and not producing protein, homocysteine is formed via methionine catabolism 8,11,27 .…”

Section: Introductionmentioning

confidence: 99%

Blood homocysteine, folic acid, vitamin B12 and vitamin B6 levels in psoriasis patients

Uslu¹,

Şendur²,

Şavk³

et al. 2017

TURKDERM

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ÖzBackground and Design: Homocysteine, a sulfur-containing amino acid, is known to be related with autoimmunity-inflammation, cardiovascular disease and DNA methylation. In this case-control study, we aimed to determine plasma homocysteine, folic acid, vitamin B12 and vitamin B6 levels in patients with psoriasis. Materials and Methods: Smoking, alcohol and coffee consumption habits were recorded in adult patients with plaque-type psoriasis and age-and sex-matched controls. Height and weight measurements were performed and Psoriasis Area and Severity Index (PASI) scores were calculated. Fasting venous blood samples were collected to determine homocysteine, folic acid, vitamin B12, vitamin B6, glucose, total cholesterol, triglyceride, high density lipoprotein (HDL), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels. Results: There was no significant difference between psoriasis patients (n=43) and controls (n=47) in body mass index and alcohol and coffee consumption. Smoking rate was significantly high in psoriasis patients. The median PASI score was 10.0 (8.3-12.8). Plasma homocysteine, folic acid, vitamin B12, vitamin B6, total cholesterol, triglyseride, ESR and CRP values were not significantly different between patients and the controls. HDL level was low in psoriasis patients (p=0.001). Plasma homocysteine level was higher in males than in females. There was no relationship of homocysteine levels with patient's age, PASI scores, ESR, CRP values and lipids. Homocysteine levels were inversely related with folic acid and vitamin B12 (p=0.000, r=-0.436, p=0.047, r=-0.204, respectively). We did not find any relationship between homocysteine and vitamin B6 levels. Conclusion: There was no increase in plasma homocysteine levels in psoriasis patients we followed up. Homocysteine level increases in inflammatory disorders and this increase is accepted as a cardiovascular disease marker. Homocysteine homeostasis may be balanced in our patients because of the genetic background and/or nutritional habits in this population Keywords: Psoriasis, homocysteine, folic acid Amaç: Homosistein kardiyovasküler hastalık, otoimmünite-enflamasyon ve DNA metilasyonu ile ilişkilendirilen sülfür içeren bir aminoasittir. Bu olgu-kontrol çalışmasında psoriazisli hastalarda plazma homosistein düzeylerinin ve homosisteini etkileyen folik asit, vitamin B6 ve vitamin B12 düzeylerinin belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Polikliniğimizde takip edilen erişkin plak tip psoriazis hastaları ile yaş ve cinsiyet uyumlu kontrol grubunda alkol, kahve ve sigara tüketimi sorgulandı, katılımcıların boy ve ağırlıkları ölçüldü. Hastaların Psoriazis Alan Şiddet İndeksleri (PAŞİ) hesaplandı. Sabah açlık kan örnekleri alınarak homosistein, folik asit, vitamin B12, vitamin B6, kan şekeri, serum total kolesterol, trigliserid, yüksek yoğunluklu lipoproteinler (HDL), eritrosit sedimantasyon hızı (ESH) ve C-reaktif protein (CRP) değerleri çalışıldı. Bulgular: Psoriazisli hasta (n=43) ve kontrol grubu (n=47) arasında vücut kitle inde...

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Assessment of Lipocalin 2, Clusterin, Soluble Tumor Necrosis Factor Receptor-1, Interleukin-6, Homocysteine, and Uric Acid Levels in Patients with Psoriasis

Cited by 40 publications

References 56 publications

Effect of psoriasis activity and topical treatment on serum lipocalin-2 levels

Effect of psoriasis activity and topical treatment on serum lipocalin-2 levels

Evaluation of serum uric acid levels in psoriasis vulgaris

Blood homocysteine, folic acid, vitamin B12 and vitamin B6 levels in psoriasis patients

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