Assessment of laboratory tests and intraoperative bleeding in patients with liver cirrhosis undergoing tooth extractions

Andrade, Natália Silva; Bueno, Marcus Vinícius; Peres, Maria Paula Siqueira De Melo; Medina, Janaina Braga; Tenório, Jefferson da Rocha; Rech, Bruna de Oliveira; Ortega, Karem L.

doi:10.1016/j.oooo.2021.05.010

Cited by 5 publications

(6 citation statements)

References 35 publications

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“…The remaining part of the collect blood and the saliva specimens were stored at -80°C until molecular analysis. The blood specimens were centrifuged and only plasma was stored ( 17 ).…”

Section: Methodsmentioning

confidence: 99%

Quantification of Torque Teno Virus (TTV) in plasma and saliva of individuals with liver cirrhosis: a cross sectional study

et al. 2023

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IntroductionTorque teno virus (TTV) has been pointed as an endogenous marker of immune function, the objective of this study was to investigate the TTV viral load in plasma and saliva of cirrhotic individuals and correlate it with clinical characteristics.MethodsBlood, saliva, clinical data from records and laboratory tests were collected from 72 cirrhotic patients. Plasma and saliva were submitted to real-time polymerase chain reaction for quantification of TTV viral load.ResultsThe majority of the patients presented decompensated cirrhosis (59.7%) and 47.2% had alterations in the white blood series. TTV was identified in 28 specimens of plasma (38.8%) and in 67 specimens of saliva (93.0%), with median values of TTV copies/mL of 90.6 in plasma and 245.14 in saliva. All the patients who were positive for TTV in plasma were also positive in saliva, with both fluids having a moderately positive correlation for the presence of TTV. There was no correlation between TTV viral load, either in plasma or in saliva, and any of the variables studied.ConclusionTTV is more frequently found and in greater amount in the saliva than in the plasma of cirrhotic patients. There was no correlation between TTV viral load and clinical parameters.

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“…The remaining part of the collect blood and the saliva specimens were stored at -80°C until molecular analysis. The blood specimens were centrifuged and only plasma was stored ( 17 ).…”

Section: Methodsmentioning

confidence: 99%

Quantification of Torque Teno Virus (TTV) in plasma and saliva of individuals with liver cirrhosis: a cross sectional study

et al. 2023

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“…In addition, two coagulation factors including INR and TT were integrated into the model, although the two coagulation factors are closely related in clinical practice 28 , 29 , which was may lead to over fitting of the model and overestimate the role of coagulation factors. However, we calculated the VIF value of relevant factors and did not show collinearity.…”

Section: Discussionmentioning

confidence: 99%

A machine learning-based model analysis for serum markers of liver fibrosis in chronic hepatitis B patients

Zhang,

Shu,

Chen

et al. 2024

Sci Rep

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Early assessment and accurate staging of liver fibrosis may be of great help for clinical diagnosis and treatment in patients with chronic hepatitis B (CHB). We aimed to identify serum markers and construct a machine learning (ML) model to reliably predict the stage of fibrosis in CHB patients. The clinical data of 618 CHB patients between February 2017 and September 2021 from Zhejiang Provincial People's Hospital were retrospectively analyzed, and these data as a training cohort to build the model. Six ML models were constructed based on logistic regression, support vector machine, Bayes, K-nearest neighbor, decision tree (DT) and random forest by using the maximum relevance minimum redundancy (mRMR) and gradient boosting decision tree (GBDT) dimensionality reduction selected features on the training cohort. Then, the resampling method was used to select the optimal ML model. In addition, a total of 571 patients from another hospital were used as an external validation cohort to verify the performance of the model. The DT model constructed based on five serological biomarkers included HBV-DNA, platelet, thrombin time, international normalized ratio and albumin, with the area under curve (AUC) values of the DT model for assessment of liver fibrosis stages (F0-1, F2, F3 and F4) in the training cohort were 0.898, 0.891, 0.907 and 0.944, respectively. The AUC values of the DT model for assessment of liver fibrosis stages (F0-1, F2, F3 and F4) in the external validation cohort were 0.906, 0.876, 0.931 and 0.933, respectively. The simulated risk classification based on the cutoff value showed that the classification performance of the DT model in distinguishing hepatic fibrosis stages can be accurately matched with pathological diagnosis results. ML model of five serum markers allows for accurate diagnosis of hepatic fibrosis stages, and beneficial for the clinical monitoring and treatment of CHB patients.

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“…The patient's bleeding was measured by subtracting the amounts of fluid aspired, saline solution used for irrigation and saliva produced per minute (by sialometry). Patients having severe bleeding were submitted to local haemostatic measures in which tranexamic acid paste (macerated with saline solution) was used in an intra and/or extra‐alveolar fashion according to the operator's criterion (Buhatem Medeiros et al, 2017; Franco et al, 2022).…”

Section: Methodsmentioning

confidence: 99%

Bleeding during tooth extraction in patients with chronic kidney disease: A cross‐sectional pilot study

et al. 2023

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ObjectiveThis work measures the intra‐operative bleeding in end‐stage renal disease patients and assesses whether laboratory coagulation tests and nitrogenous compounds are related to a higher bleeding risk.MethodsLaboratory tests were performed on the day of surgery and some patients with thrombocytopenia and values above the normal levels of international normalised ratio (INR), thrombin time (TT) and activated partial thromboplastin time (aPTT) were identified.ResultsHaemostatic time ranged from 2 to 35 min (mean of 8.51 min) after suture. Bleeding volume ranged from 0.02 to 67.06 mL (mean of 4.38 mL) and the bleeding volume per minute ranged from 0.05 to 2.10 mL/min (median of 0.6 mL/min). Only seven patients (16.27%) had abnormal bleeding (more than 0.6 mL/min). Spearman's coefficient showed weak correlations between bleeding volume (mL/min) and serum urea (r = 0.226), TT (r = 0.227), plasma urea (r = 0.148) and creatinine (r = 146), as well as very weak correlations with all other variables (r < 0.140) such as age, haemodialysis time, glycaemia, glycated haemoglobin, platelets, INR, aPTT and fibrinogen.ConclusionIt was not possible to associate any laboratory test or nitrogenous compounds present in the blood and saliva with an increased bleeding.

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Assessment of laboratory tests and intraoperative bleeding in patients with liver cirrhosis undergoing tooth extractions

Cited by 5 publications

References 35 publications

Quantification of Torque Teno Virus (TTV) in plasma and saliva of individuals with liver cirrhosis: a cross sectional study

Quantification of Torque Teno Virus (TTV) in plasma and saliva of individuals with liver cirrhosis: a cross sectional study

A machine learning-based model analysis for serum markers of liver fibrosis in chronic hepatitis B patients

Bleeding during tooth extraction in patients with chronic kidney disease: A cross‐sectional pilot study

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